Patents by Inventor Shaoling Huang

Shaoling Huang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Echogenic vehicle for clinical delivery of plasminogen activator and other fibrin-binding therapeutics to thrombi
    Patent number: 10357448
    Abstract: We disclose a composition comprising an echogenic liposome (ELIP) having an exterior surface, an interior surface, and at least one bilayer comprising at least one lipid selected from the group consisting of saturated phospholipids, unsaturated phospholipids, mixed phospholipids, and cholesterol, and a thrombolytic compound trapped by the ELIP. We also disclose a method of treating a medical condition in a patient characterized by a thrombus in the patient's vasculature, comprising administering to the patient the composition in an amount effective to reduce the size of the thrombus.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: July 23, 2019
    Assignee: Board of Regents, The University of Texas System
    Inventors: Susan T. Laing, Shaoling Huang, David D. McPherson, Christy K. Holland, Melvin E. Klegerman
  • Echogenic Vehicle for Clinical Delivery of Plasminogen Activator and Other Fibrin-Binding Therapeutics to Thrombi
    Publication number: 20180042841
    Abstract: We disclose a composition comprising an echogenic liposome (ELIP) having an exterior surface, an interior surface, and at least one bilayer comprising at least one lipid selected from the group consisting of saturated phospholipids, unsaturated phospholipids, mixed phospholipids, and cholesterol, and a thrombolytic compound trapped by the ELIP. We also disclose a method of treating a medical condition in a patient characterized by a thrombus in the patient's vasculature, comprising administering to the patient the composition in an amount effective to reduce the size of the thrombus.
    Type: Application
    Filed: October 10, 2017
    Publication date: February 15, 2018
    Applicants: Board of Regents, The University of Texas System, Univeristy of Cincinnati
    Inventors: Susan T. Laing, Shaoling Huang, David D. McPherson, Christy K. Holland, Melvin E. Klegerman
  • Echogenic vehicle for clinical delivery of plasminogen activator and other fibrin-binding therapeutics to thrombi
    Patent number: 9814672
    Abstract: We disclose a composition comprising an echogenic liposome (ELIP) having an exterior surface, an interior surface, and at least one bilayer comprising at least one lipid selected from the group consisting of saturated phospholipids, unsaturated phospholipids, mixed phospholipids, and cholesterol, and a thrombolytic compound trapped by the ELIP. We also disclose a method of treating a medical condition in a patient characterized by a thrombus in the patient's vasculature, comprising administering to the patient the composition in an amount effective to reduce the size of the thrombus.
    Type: Grant
    Filed: March 7, 2008
    Date of Patent: November 14, 2017
    Inventors: Susan T. Laing, Shaoling Huang, David D. McPherson, Christy K. Holland, Melvin E. Klegerman
  • Gas-containing liposomes
    Patent number: 7976743
    Abstract: The present invention provides gas-containing liposomes. In particular, the present invention provide methods of generating gas-containing liposomes where the gas is introduced under pressure, as well as gas-containing liposomes which contain a large volume of gas (e.g., 10 ul of gas per 5 mg of gas-containing liposomes). In certain embodiments, the gas-containing liposomes contain nitric oxide gas. In some embodiments, such nitric oxide containing liposomes are used to treat a medical condition that is treatable by nitric oxide gas (e.g., intimal hyperplasia).
    Type: Grant
    Filed: October 16, 2007
    Date of Patent: July 12, 2011
    Assignees: Northwestern University, Board of Regents, The University of Texas System
    Inventors: Shaoling Huang, Patrick Kee, Robert C. MacDonald, David McPherson
  • Echogenic Vehicle for Clinical Delivery of Plasminogen Activator and Other Fibrin-Binding Therapeutics to Thrombi
    Publication number: 20080305156
    Abstract: We disclose a composition comprising an echogenic liposome (ELIP) having an exterior surface, an interior surface, and at least one bilayer comprising at least one lipid selected from the group consisting of saturated phospholipids, unsaturated phospholipids, mixed phospholipids, and cholesterol, and a thrombolytic compound trapped by the ELIP. We also disclose a method of treating a medical condition in a patient characterized by a thrombus in the patient's vasculature, comprising administering to the patient the composition in an amount effective to reduce the size of the thrombus.
    Type: Application
    Filed: March 7, 2008
    Publication date: December 11, 2008
    Inventors: Susan T. Laing, Shaoling Huang, David D. McPherson, Christy K. Holland, Melvin E. Klegerman
  • GAS-CONTAINING LIPOSOMES
    Publication number: 20080175893
    Abstract: The present invention provides gas-containing liposomes. In particular, the present invention provide methods of generating gas-containing liposomes where the gas is introduced under pressure, as well as gas-containing liposomes which contain a large volume of gas (e.g., 10 ul of gas per 5 mg of gas-containing liposomes). In certain embodiments, the gas-containing liposomes contain nitric oxide gas. In some embodiments, such nitric oxide containing liposomes are used to treat a medical condition that is treatable by nitric oxide gas (e.g., intimal hyperplasia).
    Type: Application
    Filed: October 16, 2007
    Publication date: July 24, 2008
    Applicant: NORTHWESTERN UNIVERSITY
    Inventors: Shaoling Huang, Robert C. MacDonald, Patrick Kee, David McPherson