Abstract: The present disclosure relates to a baseboard management controller (BMC)-based switch monitoring method, a system, a computer device, and a readable medium thereof. The BMC-based switch monitoring method includes: virtualizing a multi-core BMC into a plurality of logical computers such that each core operates separately; in response to start of a switch, migrating functions of the switch into a first core of the multi-core BMC for start, and monitoring other cores of the multi-core BMC based on a second core of the multi-core BMC; determining, in response to that a new service is received by the switch is detected, whether the new service is a firmware upgrade service; and allocating the new service to the second core in the multi-core BMC for operation, in response to that the new service is the firmware upgrade service.

Abstract: The present disclosure relates to a baseboard management controller (BMC)-based switch monitoring method, a system, a computer device, and a readable medium thereof. The BMC-based switch monitoring method includes: virtualizing a multi-core BMC into a plurality of logical computers such that each core operates separately; in response to start of a switch, migrating functions of the switch into a first core of the multi-core BMC for start, and monitoring other cores of the multi-core BMC based on a second core of the multi-core BMC; determining, in response to that a new service is received by the switch is detected, whether the new service is a firmware upgrade service; and allocating the new service to the second core in the multi-core BMC for operation, in response to that the new service is the firmware upgrade service.

Abstract: Described herein are methods and compositions for genomic editing. Clustered regularly interspaced short palindromic (CRISPR) allows for highly selective targeting and alteration of genetic loci. Here, the Inventors demonstrate CRISPR as capable of being used in living animals to prophylactically prevent a genetic disease from manifesting. Targeting and disruption of mutated rhodopsin gene prevents progression of retinitis pigmentosa in the retinal cells of a transgenic rat model. Such techniques allow for treatment methods in subjects with dominant genetic mutations, often associated with lack of a gene product, or a toxic gene product. The described technology effectively abrogates deleterious effects due to the presence of a mutated gene copy allowing the normal function of the wild-type protein to prevent cell and vision loss. The efficacy of these in vivo mechanisms are widely extensible to similar dominant negative gene mutations causing disease, or other types of genetic disease.