Patents by Inventor Shaomeng Wang

Shaomeng Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190263827
    Abstract: The present disclosure provides compounds represented by Formula I: I, and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1, R2a, R2b, R3, R4, Ar, L, X, Y, and B are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat a condition or disorder responsive to degradation of BET bromodomains such as cancer.
    Type: Application
    Filed: September 13, 2017
    Publication date: August 29, 2019
    Inventors: Shaomeng Wang, Yang Hu, Chong Qin, Fuming Xu, Jiantao Hu, Weiguo Xiang, Bing Zhou
  • Patent number: 10391175
    Abstract: Inhibitors of BET bromodomains and compositions containing the same are disclosed. Methods of using the BET bromodomain inhibitors in the treatment of diseases and conditions wherein inhibition of BET bromodomain provides a benefit, like cancers, also are disclosed.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: August 27, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Shaomeng Wang, Xu Ran, Yujun Zhao, Chao-Yie Yang, Liu Liu, Longchuan Bai, Donna McEachern, Jeanne Stuckey, Jennifer Lynn Meagher, Duxin Sun, Xiaoqin Li, Bing Zhou, Hacer Karatas, Ruijuan Luo, Arul Chinnaiyan, Irfan A. Asangani
  • Publication number: 20190175595
    Abstract: The present disclosure provides compounds represented by Formula I: and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1a, R1b, R2a, R2b, R3, R4, R5, R6, and R7 are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat a condition or disorder responsive to inhibition of ALK such as cancer.
    Type: Application
    Filed: August 28, 2017
    Publication date: June 13, 2019
    Inventors: Shaomeng WANG, Jianyong CHEN
  • Publication number: 20190169195
    Abstract: The present disclosure provides compounds represented by Formula I: and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein B, R1, R5, Q1, Q?, L, X, Y, and Z are as defined as set forth in the specification. The present disclosure also provids compounds of Formula I for use to treat a condition or disorder responsive to degradation of BET bromodomains such as cancer.
    Type: Application
    Filed: April 6, 2017
    Publication date: June 6, 2019
    Inventors: Shaomeng Wang, Bing Zhou, Fuming Xu, Jiantao Hu, Longchuan Bai, Chao-Yie Yang
  • Patent number: 10307407
    Abstract: The present disclosure provides substituted 9H-pyrimido [4,5-b] indoles and 5H-pyrido [4,3-b] indoles and related analogs represented by Formula I and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1a, W, B1, B2, G, X1, Y1, Y2, and Y3 are as defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a condition or disorder responsive to inhibition of BET bromodomains such as cancer. The present disclosure is also directed to the use of compound of Formula I as synthetic intermediates.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: June 4, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Shaomeng Wang, Yujun Zhao, Bing Zhou, Angelo Aguilar
  • Publication number: 20190152947
    Abstract: The present disclosure provides compounds by Formula (I): (Formula(I)) and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R2, R3a, R3b, A, G, X, and Y are as defined as set forth in the specification. The present disclosure also provides compounds of Formula (I) for use to treat a condition or disorder responsive to menin inhibition such as cancer.
    Type: Application
    Filed: May 2, 2017
    Publication date: May 23, 2019
    Inventors: Shaomeng Wang, Angelo Aguilar, Ke Zheng, Shilin Xu, Tianfeng Xu, Denzil Bernard, Liyue Huang
  • Publication number: 20190127387
    Abstract: The present disclosure provides compounds represented by Formula I-A: A1-L1-B1 I-A and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein A1, B1, and L1 are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I-A for use to treat a condition or disorder responsive to degradation of MDM2 protein such as cancer.
    Type: Application
    Filed: April 6, 2017
    Publication date: May 2, 2019
    Inventors: Shaomeng Wang, Yangbing Li, Jiuling Yang, Angelo Aguilar, Bing Zhou, Jiantao Hu, Fuming Xu, Rohan Rej, Xin Han
  • Publication number: 20190119289
    Abstract: The present disclosure provides compounds represented by Formula I: and the salts or solvates thereof, wherein X, L, Y, and B are as defined in the specification. Compounds having Formula I are immunomodulators and/or monofunctional synthetic intermediates that can be used to prepare small-molecule drug conjugates.
    Type: Application
    Filed: April 6, 2017
    Publication date: April 25, 2019
    Inventors: Shaomeng Wang, Yangbing Li, Angelo Aguilar, Bing Zhou, Jiantao Hu, Fuming Xu, Chong Qin, Yang Hu, Weiguo Xiang, Rohan Rej, Jiuling Yang, Xin Han, Longchuan Bai, Chao-Yie Yang
  • Patent number: 10253044
    Abstract: The present disclosure provides substituted 9H-pyrimido[4,5-b]indoles and 5H-pyrido[4,3-b]indoles and related analogs represented by Formula I: and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1a, A, B1, B2, G, X1, Y1, Y2, and Y3 are as defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a condition or disorder responsive to inhibition of BET bromodomains. Compounds of the present disclosure are especially useful for treating cancer.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: April 9, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Shaomeng Wang, Yujun Zhao, Bing Zhou, Angelo Aguilar, Liu Liu, Longchuan Bai, Donna McEachern, Duxin Sun, Bo Wen, Ruijuan Luo, Ting Zhao, Arul Chinnaiyan, Irfan A. Asangani, Jeanne Stuckey, Jennifer Lynn Meagher, Xu Ran, Yang Hu
  • Publication number: 20190102383
    Abstract: There is provided an association analysis method and apparatus. An original database is divided into projection databases, each not contributing to a support count of a frequent item set of another. The projection databases are used for sequential-pattern association analysis performed respectively by nodes corresponding to the projection databases. Local frequent item sets and corresponding support counts obtained by the nodes are combined. Since an established projection database does not contribute a support count of a frequent item set of another projection database, different nodes can perform association mining, including pruning, on different projection databases respectively.
    Type: Application
    Filed: August 21, 2018
    Publication date: April 4, 2019
    Inventors: Bin DAI, Xu YANG, Xiaoyan JIANG, Ning CAI, Shaomeng WANG
  • Patent number: 10221174
    Abstract: The present disclosure provides compounds having Formula I-A: and the pharmaceutically acceptable salts and solvates thereof, wherein A, X1, X2, X3 R1a, R1b, E, and are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I-A for use to treat a disease, disorder, or condition responsive to Bcl-2 protein inhibition such as cancer.
    Type: Grant
    Filed: August 1, 2018
    Date of Patent: March 5, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Shaomeng Wang, Jianyong Chen
  • Publication number: 20190034516
    Abstract: The disclosed embodiments provide a method and an apparatus for acquiring an evaluation index. The method comprises the steps of inputting samples into a classification model for classification training and acquiring output data of the classification model; acquiring probability statistics by performing probability distribution on the output data, wherein the probability statistics comprise probability intervals and a number of true positive samples and a number of true negative samples in each probability interval; and calculating the evaluation index of the classification model according to a threshold set and the acquired probability statistics. In the disclosed embodiments, probability statistics is performed for the output data of the classification model; and the evaluation index is calculated based on the acquired probability statistics, thereby solving the problem of scanning output data multiple times during the calculation of evaluation index.
    Type: Application
    Filed: January 24, 2017
    Publication date: January 31, 2019
    Inventors: Xiaoyan JIANG, Shaomeng WANG, Xu YANG, Ning CAI
  • Publication number: 20190034834
    Abstract: Methods and apparatuses for training model based on random forest are provided. The method includes: dividing worker nodes into one or more groups; performing random sampling, by worker nodes in each group, in the preset sample data to obtain the target sample data; and training, by the worker nodes in each group, one or more decision tree objects using the target sample data. Example embodiments of the present disclosure do not need to scan the complete sample data for once, thereby greatly reducing the amount of data to be read, the time cost, and further the iterative update time of the model. The efficiency of training is improved.
    Type: Application
    Filed: September 28, 2018
    Publication date: January 31, 2019
    Inventors: Xiaoyan Jiang, Shaomeng Wang, Xu Yang
  • Publication number: 20180365521
    Abstract: Embodiments of the present disclosure provide a method and system for training a model by using training data. The training data includes a plurality of samples, each sample includes N features, and features in the plurality of samples form N feature columns, and the method includes: determining an importance value of each of the N feature columns; determining whether the importance value of each of the N feature columns satisfies a threshold condition; performing a dimension reduction on M feature columns to generate P feature columns in response to the determination that the importance values of the M feature columns do not satisfy the threshold condition, wherein M<N and P<M; merging (N?M) feature columns having importance values that satisfy the threshold condition and the generated P feature columns to obtain (N?M+P) feature columns; and training the model based on the training data including the (N?M+P) feature columns.
    Type: Application
    Filed: August 24, 2018
    Publication date: December 20, 2018
    Inventors: Bin DAI, Shen LI, Xiaoyan JIANG, Xu YANG, Yuan QI, Wei CHU, Shaomeng WANG, Zihao FU
  • Publication number: 20180354950
    Abstract: The present disclosure provides compounds having Formula I-A: and the pharmaceutically acceptable salts and solvates thereof, wherein A, X1, X2, X3 R1a, R1b, E, and are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I-A for use to treat a disease, disorder, or condition responsive to Bcl-2 protein inhibition such as cancer.
    Type: Application
    Filed: August 1, 2018
    Publication date: December 13, 2018
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Shaomeng Wang, Jianyong Chen
  • Publication number: 20180341801
    Abstract: The present disclosure provides feature data processing methods and devices. One exemplary feature data processing method comprises: classifying features into an important feature set and an auxiliary feature set according to information attribute values of the features; converting features in the auxiliary feature set to hash features; and combining the hash features with features in the important feature set, and setting the combined features as fingerprint features. Training and prediction of to-be-processed data can be performed based on the fingerprint features. With the embodiments of the present disclosure, training dimensions can be more controllable and the amount training data amount can be reduced. Therefore, the efficiency of data processing can be improved.
    Type: Application
    Filed: July 18, 2018
    Publication date: November 29, 2018
    Inventors: Bin DAI, Shen LI, Xiaoyan JIANG, Xu YANG, Yuan QI, Wei CHU, Shaomeng WANG, Zihao FU
  • Publication number: 20180289677
    Abstract: Small molecule covalent inhibitors of DCN1 and compositions containing the same are disclosed. Methods of using the DCN1 covalent inhibitors in the treatment of diseases and conditions wherein inhibition of DCN1 provides a benefit, like oxidative stress-related diseases and conditions, neurodegenerative diseases and conditions, metabolic disorders, and muscular nerve degeneration, also are disclosed.
    Type: Application
    Filed: April 10, 2018
    Publication date: October 11, 2018
    Inventors: Shaomeng Wang, Haibin Zhou, Jianfeng Lu, Liu Liu, Jeanne Stuckey, Liangyou Rui, Yi Sun
  • Publication number: 20180036294
    Abstract: The present disclosure provides substituted 9H-pyrimido [4,5-b] indoles and 5H-pyrido [4,3-b] indoles and related analogs represented by Formula I and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1a, W, B1, B2, G, X1, Y1, Y2, and Y3 are as defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a condition or disorder responsive to inhibition of BET bromodomains such as cancer. The present disclosure is also directed to the use of compound of Formula I as synthetic intermediates.
    Type: Application
    Filed: February 26, 2016
    Publication date: February 8, 2018
    Inventors: Shaomeng WANG, Yujun ZHAO, Bing ZHOU, Angelo AGUILAR
  • Patent number: 9783539
    Abstract: Disclosed herein are certain indoloquinolone compounds, methods of preparation thereof, pharmaceutical compositions thereof, and uses thereof, such as their uses as ALK inhibitors.
    Type: Grant
    Filed: February 27, 2014
    Date of Patent: October 10, 2017
    Assignee: Jiangsu Ascentage Biomed Development Inc.
    Inventors: Jianyong Chen, Yunlong Zhou, Shaomeng Wang, Ming Guo, Dajun Yang, Lingling Jiao, Yu Jing, Xu Qian, Liu Liu, Longchuan Bai, Chao-Yie Yang, Donna McEachern
  • Publication number: 20170281773
    Abstract: Inhibitors of BET bromodomains and compositions containing the same are disclosed. Methods of using the BET bromodomain inhibitors in the treatment of diseases and conditions wherein inhibition of BET bromodomain provides a benefit, like cancers, also are disclosed.
    Type: Application
    Filed: June 12, 2017
    Publication date: October 5, 2017
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Shaomeng Wang, Xu Ran, Yujun Zhao, Chao-Yie Yang, Liu Liu, Longchuan Bai, Donna McEachern, Jeanne Stuckey, Jennifer Lynn Meagher, Duxin Sun, Xiaoqin Li, Bing Zhou, Hacer Karatas, Ruijuan Luo, Arul Chinnaiyan, Irfan A. Asangani