Abstract: A nanoparticle comprising a core and a shell, wherein the core includes an antimicrobial and hemoglobin, the shell includes a polyunsaturated fatty acids (PUFA)-containing cell membrane, and the antimicrobial sensitizes bacteria to oxidant killing.

Abstract: The present technology provides nanoparticles comprising a positively charged polymer (e.g., polylysine) electrostatically bound to iron oxide nanoparticles and CpG oligodeoxy nucleotide. Further provided are compositions comprising same and methods of sensitizing tumor cells to radiation therapy, methods of stimulating antigen presenting cells, methods of enhancing stimulation of a type I interferon, and methods of treatment using said nanoparticles and compositions.

Abstract: The present disclosure relates to unimolecular core-shell nanoparticle, nanoclusters thereof, and platelet biomimetic nanoclusters thereof. The disclosed compositions are useful for treating a subject with a disease or condition, such as a cardiovascular disease. In a further aspect, the cardiovascular disease can be a vascular stenosis or restenosis. Also described herein are methods of making and using the unimolecular core-shell nanoparticle, nanoclusters thereof, and platelet biomimetic nanoclusters thereof. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: In one aspect, the disclosure relates to nanoclusters comprising cores comprising self-assembled unimolecular nanoparticles and biomimetic membrane coatings surrounding the cores, methods of making the same, and methods of treating and preventing restenosis using same. In some embodiments, the nanoclusters can contain an anti-restenotic drug. In one embodiment, the polymers and/or copolymers of the unimolecular nanoparticles can contain a hydrophobic group such as, for example, a phenylboronic ester. In a further embodiment, the biomimetic membrane can localize the nanoclusters at sites of vascular damage, at which time reactive oxygen species (ROS) at the sites of vascular damage cleave the hydrophobic groups from the polymers and/or copolymers, increasing hydrophilicity of the polymers and/or copolymers and allowing for greater tissue penetration of the de-clustered nanoclusters and nanoparticles.

Abstract: The present technology provides disulfide-containing lipopeptides of Formula I. Such lipids may be incorporated into lipid nanoparticles for delivery of nucleic acids, nucleotides (e.g., NAD+ or NADH), polypeptides (including proteins), and complexes of proteins and nucleic acids, e.g., Cas9 RNP. The present technology also provides methods for delivering the nanoparticles to a cell and methods of treating a condition or disorder using the lipid nanoparticles.

Abstract: Techniques manage tracking records in an application system which includes an active dump file and an inactive dump file. A set of tracking records indicating a state of the application system is received. The set of tracking records is added to the active dump file. A storage signal for storing the active dump file into a backup device associated with the application system is generated according to a determination that a size of the active dump file meets a predetermined size threshold and according to a determination that a state of the inactive dump file is a ready state. The ready state indicates that the inactive dump file is available for storing another set of tracking records to be received in the future. Accordingly, two dump files may alternately store tracking records, and copies of the dump files may be continuously stored into a backup device to improve reliability.

Abstract: In one aspect, the disclosure relates to unimolecular micelles having N-hydroxysuccinimide ester (NHS), sulfo-NHS terminal groups, or other adhesive terminal groups, compositions including the same, methods of making the same, and methods of treating intimal hyperplasia in a subject using the same. In some aspects, the unimolecular micelles can further include fluorescent labels or drugs for treating intimal hyperplasia. In one aspect, the unimolecular micelles and compositions comprising the same are biocompatible, non-toxic, and non-inflammatory. In another aspect, the unimolecular micelles and compositions are substantially free from hydrogel, or are completely free from hydrogel. In still another aspect, the disclosed compositions and methods can be easily and quickly deployed in the operating room. Also disclosed is a method of applying the unimolecular micelles and compositions via direct penbrush painting.

Abstract: Photoreceptor scaffolds that can be used for transplantation of organized photoreceptor tissue, with or without retinal pigment epithelial cells, which may improve grafted cell survival, integration, and functional visual rescue are disclosed herein. The scaffolds include a cell support layer having at least one honeycomb-shaped reservoir fluidly connected to a plurality of through-holes and at least one cell in the at least one honeycomb-shaped reservoir.

Abstract: Flexible transistors and electronic circuits incorporating the transistors are provided. The flexible transistors promote heat dissipation from the active regions of the transistors while preserving their mechanical flexibility and high-frequency performance. The transistor designs utilize thru-substrate vias (TSVs) beneath the active regions of thin-film type transistors on thin flexible substrates. To promote rapid heat dissipation, the TSVs are coated with a material having a high thermal conductivity that transfers heat from the active region of the transistor to a large-area ground.

Abstract: A technique manages a computing system based on a client/server architecture. In particular, an address mapping of a storage system is managed. The address mapping includes an association between storage spaces in a plurality of storage devices in the storage system and a user of the storage system. A data access service is provided to a client associated with the user based on the address mapping. The client includes at least any one of a user data client for accessing user data associated with the user in the storage system and a control data client for accessing control data associated with the user. Based on a client/server architecture, a uniform management mode is provided for user data and control data, so that the storage system is managed more simply and effectively.

Abstract: Photoreceptor scaffolds that can be used for transplantation of organized photoreceptor tissue, with or without retinal pigment epithelial cells, which may improve grafted cell survival, integration, and functional visual rescue are disclosed herein. The scaffolds include a cell support layer having at least one honeycomb-shaped reservoir fluidly connected to a plurality of through-holes and at least one cell in the at least one honeycomb-shaped reservoir.

Abstract: Provided herein are polymer-drug conjugates with enhanced antibacterial efficacy. These conjugates include a polymer comprising a plurality of masked cationic functional groups and an antibiotic drug linked to the cationic polymer by a pH-sensitive linker. The masked cationic functional groups may be converted in aqueous solution to free cationic functional groups faster at a pH below 7 than a pH above 7. The cationic functional groups may be masked as either an uncharged functional group or by an ion pair with a neighboring anionic functional group attached to the polymer. The pH-sensitive linker releases the drug faster in aqueous solution at or below a pre-determined pH value selected from a range of 4.5 to 7 than a pH value above 7.

Abstract: The present disclosure relates to unimolecular core-shell nanoparticle, nanoclusters thereof, and platelet biomimetic nanoclusters thereof. The disclosed compositions are useful for treating a subject with a disease or condition, such as a cardiovascular disease. In a further aspect, the cardiovascular disease can be a vascular stenosis or restenosis. Also described herein are methods of making and using the unimolecular core-shell nanoparticle, nanoclusters thereof, and platelet biomimetic nanoclusters thereof. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: Techniques for allocating storage space of disks in a storage system involve selecting a current storage node from a plurality of storage nodes according to at least one previously selected storage node and association relationships between the plurality of storage nodes. Such techniques further involve selecting a current disk from a plurality of disks according to at least one previously selected disk, the current storage node, and association relationships between the plurality of disks. Such techniques further involve allocating at least one slice in the current disk to a redundant array of independent disks (RAID) stripe. Such a technique can support a distributed storage system having more storage nodes, can greatly reduce the time for allocating the storage space of disks, and can make a RAID stripe evenly allocated between the storage nodes and the disks in the storage system, thereby greatly improving a success rate of data recovery.

Abstract: Techniques for storage management involve determining, based at least on an upper limit duration for recovering a predetermined number of disk sets among a plurality of disk sets, a first recovery rate for recovering at least a portion of the plurality of disk sets. The techniques may further involve determining the number of disk sets that are not recovered based on the first recovery rate among the plurality of disk sets. In addition, the techniques may further involve performing data recovery on unrecovered disk sets among the plurality of disk sets based on a predetermined second recovery rate according to the determined number being less than or equal to the predetermined number, the second recovery rate being lower than the first recovery rate and being associated with the upper limit duration. Accordingly, it can be ensured that all to-be-recovered disk sets may be recovered within a recovery duration.

Abstract: Techniques involve: determining a first group of storage disks, a use rate of each storage disk of the first group of storage disks exceeding a first threshold, the first group of storage disks comprising a first group of storage blocks corresponding to a first redundant array of independent storage disk (RAID); allocating a second group of storage blocks corresponding to a second RAID from a second group of storage disks, the second group of storage blocks having the same size as that of the first group of storage blocks, a use rate of each storage disk of the second group of storage disks being under a second threshold; moving data in the first group of storage blocks to the second group of storage blocks; and releasing the first group of storage blocks from the first group of storage disks. Thus, use rates of the storage disks become more balanced.

Abstract: The present technology provides a nanoparticle that includes a silica network comprising crosslinked polysiloxanes, wherein the crosslinks comprise disulfide linkages, and the nanoparticle has a surface bearing charged functional groups and a surface potential of either less than ?30 mV or greater than +30 mV, and wherein the nanoparticle has an average diameter of 20 nm to 60 n. The nanoparticles may be used to efficiently deliver biomolecules to plant cells, including polynucleic acids, proteins and complexes thereof (e.g., Cas9 RNP).

Abstract: Provided herein are peptides comprising an amino acid sequence having at least about 85% sequence identity to RYRPRAPIIAVT (SEQ ID NO: 1). These cationic peptides inhibit PKM2 methylation and may be used in the treatment of breast cancer and other diseases or conditions in which PKM2 is overexpressed. Such PKM2 peptides may be delivered to cancer cells using pH sensitive unimolecular nanoparticles comprising anionic polymers.

Abstract: Flexible transistors and electronic circuits incorporating the transistors are provided. The flexible transistors promote heat dissipation from the active regions of the transistors while preserving their mechanical flexibility and high-frequency performance. The transistor designs utilize thru-substrate vias (TSVs) beneath the active regions of thin-film type transistors on thin flexible substrates. To promote rapid heat dissipation, the TSVs are coated with a material having a high thermal conductivity that transfers heat from the active region of the transistor to a large-area ground.

Abstract: Techniques for data recovery involve: reading target data corresponding to a first logical block from a first data block of a stripe of a RAID system, the target data being a compressed version of data in the first logical block; in accordance with a determination that an error occurs in the target data, reading data from a plurality of second data blocks of the stripe and first parity information from a first parity block of the stripe; comparing respective checksums of the data read from the plurality of second data blocks with a first predetermined checksum and a checksum of the first parity information with a second predetermined checksum; and determining recoverability of the target data based on a result of the comparison. Accordingly, it is possible to simplify the data recovery process, reduce the calculation and time costs in the data recovery, and improve the data recovery efficiency.