Abstract: Photoreceptor scaffolds that can be used for transplantation of organized photoreceptor tissue, with or without retinal pigment epithelial cells, which may improve grafted cell survival, integration, and functional visual rescue are disclosed herein. The scaffolds include a cell support layer having at least one honeycomb-shaped reservoir fluidly connected to a plurality of through-holes and at least one cell in the at least one honeycomb-shaped reservoir.

Abstract: Provided herein are polymer-drug conjugates with enhanced antibacterial efficacy. These conjugates include a polymer comprising a plurality of masked cationic functional groups and an antibiotic drug linked to the cationic polymer by a pH-sensitive linker. The masked cationic functional groups may be converted in aqueous solution to free cationic functional groups faster at a pH below 7 than a pH above 7. The cationic functional groups may be masked as either an uncharged functional group or by an ion pair with a neighboring anionic functional group attached to the polymer. The pH-sensitive linker releases the drug faster in aqueous solution at or below a pre-determined pH value selected from a range of 4.5 to 7 than a pH value above 7.

Abstract: The present disclosure relates to unimolecular core-shell nanoparticle, nanoclusters thereof, and platelet biomimetic nanoclusters thereof. The disclosed compositions are useful for treating a subject with a disease or condition, such as a cardiovascular disease. In a further aspect, the cardiovascular disease can be a vascular stenosis or restenosis. Also described herein are methods of making and using the unimolecular core-shell nanoparticle, nanoclusters thereof, and platelet biomimetic nanoclusters thereof. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: Techniques for allocating storage space of disks in a storage system involve selecting a current storage node from a plurality of storage nodes according to at least one previously selected storage node and association relationships between the plurality of storage nodes. Such techniques further involve selecting a current disk from a plurality of disks according to at least one previously selected disk, the current storage node, and association relationships between the plurality of disks. Such techniques further involve allocating at least one slice in the current disk to a redundant array of independent disks (RAID) stripe. Such a technique can support a distributed storage system having more storage nodes, can greatly reduce the time for allocating the storage space of disks, and can make a RAID stripe evenly allocated between the storage nodes and the disks in the storage system, thereby greatly improving a success rate of data recovery.

Abstract: Techniques for storage management involve determining, based at least on an upper limit duration for recovering a predetermined number of disk sets among a plurality of disk sets, a first recovery rate for recovering at least a portion of the plurality of disk sets. The techniques may further involve determining the number of disk sets that are not recovered based on the first recovery rate among the plurality of disk sets. In addition, the techniques may further involve performing data recovery on unrecovered disk sets among the plurality of disk sets based on a predetermined second recovery rate according to the determined number being less than or equal to the predetermined number, the second recovery rate being lower than the first recovery rate and being associated with the upper limit duration. Accordingly, it can be ensured that all to-be-recovered disk sets may be recovered within a recovery duration.

Abstract: Techniques involve: determining a first group of storage disks, a use rate of each storage disk of the first group of storage disks exceeding a first threshold, the first group of storage disks comprising a first group of storage blocks corresponding to a first redundant array of independent storage disk (RAID); allocating a second group of storage blocks corresponding to a second RAID from a second group of storage disks, the second group of storage blocks having the same size as that of the first group of storage blocks, a use rate of each storage disk of the second group of storage disks being under a second threshold; moving data in the first group of storage blocks to the second group of storage blocks; and releasing the first group of storage blocks from the first group of storage disks. Thus, use rates of the storage disks become more balanced.

Abstract: The present technology provides a nanoparticle that includes a silica network comprising crosslinked polysiloxanes, wherein the crosslinks comprise disulfide linkages, and the nanoparticle has a surface bearing charged functional groups and a surface potential of either less than ?30 mV or greater than +30 mV, and wherein the nanoparticle has an average diameter of 20 nm to 60 n. The nanoparticles may be used to efficiently deliver biomolecules to plant cells, including polynucleic acids, proteins and complexes thereof (e.g., Cas9 RNP).

Abstract: Provided herein are peptides comprising an amino acid sequence having at least about 85% sequence identity to RYRPRAPIIAVT (SEQ ID NO: 1). These cationic peptides inhibit PKM2 methylation and may be used in the treatment of breast cancer and other diseases or conditions in which PKM2 is overexpressed. Such PKM2 peptides may be delivered to cancer cells using pH sensitive unimolecular nanoparticles comprising anionic polymers.

Abstract: Flexible transistors and electronic circuits incorporating the transistors are provided. The flexible transistors promote heat dissipation from the active regions of the transistors while preserving their mechanical flexibility and high-frequency performance. The transistor designs utilize thru-substrate vias (TSVs) beneath the active regions of thin-film type transistors on thin flexible substrates. To promote rapid heat dissipation, the TSVs are coated with a material having a high thermal conductivity that transfers heat from the active region of the transistor to a large-area ground.

Abstract: Techniques for data recovery involve: reading target data corresponding to a first logical block from a first data block of a stripe of a RAID system, the target data being a compressed version of data in the first logical block; in accordance with a determination that an error occurs in the target data, reading data from a plurality of second data blocks of the stripe and first parity information from a first parity block of the stripe; comparing respective checksums of the data read from the plurality of second data blocks with a first predetermined checksum and a checksum of the first parity information with a second predetermined checksum; and determining recoverability of the target data based on a result of the comparison. Accordingly, it is possible to simplify the data recovery process, reduce the calculation and time costs in the data recovery, and improve the data recovery efficiency.

Abstract: The present technology provides a composition comprising a mixture of a source of calcium ions, alginate conjugated to an acrylate monomer (ALG-A), carboxymethylcellulose conjugated to an acrylate monomer (CMC-A) and water, wherein the mixture is a shear-thinning gel. The compositions may further include a polythiol agent. Such compositions are injectable due to their shear-thinning properties, yet stay in place, undergo in situ crosslinking, and provide safe, simple and efficacious endovascular embolization. Methods of making and using such compositions are also provided.

Abstract: The present technology provides nanoparticles comprising an inorganic core and NAD+ or NADH, coated with a lipid bilayer, wherein the inorganic core is selected from calcium phosphate or a metal organic framework (MOF); the MOF comprises a transition metal ion coordinated to a coordinating ligand, wherein the transition metal ion is selected from the group consisting of zinc, iron, zirconium, copper, and cobalt ions, and the coordinating ligand is selected from an imidazolate ligand or a carboxylate ligand; and the nanoparticle has an average hydrodynamic diameter of from at least 50 nm to less than 1000 nm. Pharmaceutical compositions incorporating such nanoparticles and methods of treating sepsis and/or inflammation with such particles are also provided.

Abstract: A technique manages a computing system based on a client/server architecture. In particular, an address mapping of a storage system is managed. The address mapping includes an association between storage spaces in a plurality of storage devices in the storage system and a user of the storage system. A data access service is provided to a client associated with the user based on the address mapping. The client includes at least any one of a user data client for accessing user data associated with the user in the storage system and a control data client for accessing control data associated with the user. Based on a client/server architecture, a uniform management mode is provided for user data and control data, so that the storage system is managed more simply and effectively.

Abstract: Techniques involve determining a first slice distribution used to build first storage units in a first pool; in response to a determination that the first pool is expanded to a second pool, determining, at least based on a sum of the slices having been used to build the first storage units, a second slice distribution of updated slices used to build the first storage units in the second pool; determining, based on the first distribution and the second distribution, a first available number of slices and a second available number of slices available for building second storage units in the second pool, the second storage units being different from the first storage units; and determining, at least based on the first available number and the second available number, the number of the second storage units allowed to be built. Accordingly, available capacity allowed for building can be accurately estimated.

Abstract: Technology is disclosed for recovering the consistency of a RAID (Redundant Array of Independent Disks) metadata database when data corruption is detected in the RAID metadata database. The RAID metadata database includes super sectors, stage sectors, and a data region. Valid data within the data region is a contiguous set of sectors extending from a head sector to a tail sector. In response to data corruption in one of the two super sectors, a set of pointers contained in the other super sector is used to identify the head sector and tail sector. In response to data corruption in both super sectors, the head sector and tail sector are located based on the contents of the sectors in the data region. Techniques are also disclosed for recovering consistency when the data corruption occurs in the stage sectors and/or data region.

Abstract: Techniques for managing storage blocks involve: according to a first request for allocating a target number of consecutive storage blocks from a storage device, querying an index table that is used to record index information of a plurality of groups of consecutive idle storage blocks in the storage device to determine a first group of consecutive idle storage blocks from the plurality of groups of consecutive idle storage blocks; allocating the target number of consecutive storage blocks from the first group of consecutive idle storage blocks; updating a bitmap that is used to record states of a plurality of storage blocks in the storage device; and updating first index information of the first group of consecutive idle storage blocks recorded in the index table. Accordingly, such techniques may reduce storage complexity and improve system performance.

Abstract: Flexible transistors and electronic circuits incorporating the transistors are provided. The flexible transistors promote heat dissipation from the active regions of the transistors while preserving their mechanical flexibility and high-frequency performance. The transistor designs utilize thru-substrate vias (TSVs) beneath the active regions of thin-film type transistors on thin flexible substrates. To promote rapid heat dissipation, the TSVs are coated with a material having a high thermal conductivity that transfers heat from the active region of the transistor to a large-area ground.

Abstract: Managing pool memory in a data storage system includes maintaining free lists for corresponding object sizes. For a memory-consuming request (e.g., host write) an allocation operation is performed and the request data is stored. The allocation operation includes (1) selecting a memory object at least as large as the request size and removing all pages of the selected memory object from the corresponding free list, and (2) selecting pages of the selected memory object to store the request data and marking the selected pages as non-free, and leaving any leftover pages as free pages. For a memory-freeing request (e.g., destaging), a deallocation operation is performed that includes (1) marking the request pages free, and (2) based on neighboring pages being free, merging the request pages and neighboring pages into a corresponding memory object and adding the merged pages to the corresponding free list.

Abstract: Techniques for storage management may include: adding first storage devices to a pool, wherein prior to adding the first storage devices to the pool, the pool includes second storage devices with existing physical storage units (PUs) distributed across the second storage devices; and in response to adding the first storage devices to the pool, performing processing to evenly distribute the existing PUs among the pool of storage devices, said processing including: defining logical pairs of storage devices in accordance with rules; binding each of the logical pairs to a resiliency set; determining that a first PU of the existing PUs includes disk slices that span across more than a single resiliency set; andin response to determining that the first PU includes disk slices that span across more than a single resiliency set, performing second processing to restripe the first PU in accordance with a target layout.

Abstract: Techniques for storage management may include: adding first storage devices to a pool, wherein prior to adding the first storage devices to the pool, the pool includes second storage devices with existing physical storage units (PUs) distributed across the second storage devices; and in response to adding the first storage devices to the pool, performing processing to evenly distribute the existing PUs among the pool of storage devices, said processing including: defining logical pairs of storage devices in accordance with rules; binding each of the logical pairs to a resiliency set; determining that a first PU of the existing PUs includes disk slices that span across more than a single resiliency set; and in response to determining that the first PU includes disk slices that span across more than a single resiliency set, performing second processing to restripe the first PU in accordance with a target layout.