Patents by Inventor Shaorong S. C. Chong

Shaorong S. C. Chong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified proteins comprising controllable intervening protein sequences or their elements methods of producing same and methods for purification of a target protein comprised by a modified protein
    Patent number: 5834247
    Abstract: The present invention is directed to modified proteins and methods of their production. The modified proteins comprise a controllable intervening protein sequence (CIVPS) inserted into or adjacent a target protein, the CIVPS being capable of excision from or cleavage of the modified protein under predetermined conditions in cis or in trans, i.e., increase in temperature, exposure to light, unblocking of amino acid residues by dephosphorylation, treatment with chemical reagents or deglycosylation. If desired, the modified protein can be subjected to these conditions. The CIVPS may also be inserted into a region that substantially inactivates target protein activity. The CIVPS may be used in a number of applications including purification of the target protein in a one-step protocol.
    Type: Grant
    Filed: March 5, 1997
    Date of Patent: November 10, 1998
    Assignee: New England Biolabs, Inc.
    Inventors: Donald G. Comb, Francine B. Perler, William E. Jack, Ming-Qun Xu, Robert A. Hodges, Christopher J. Noren, Shaorong S. C. Chong, Eric Adam, Maurice Southworth