Abstract: The present invention provides stem cells-derived extracellular vesicles (EVs) characterized by upregulation and/or downregulation of specific proteins. Composition comprising the EVs. and their use in the treatment of diseases and disorders associated with the upregulated proteins are also provided.

Abstract: The present invention provides pharmaceutical compositions comprising membrane vesicles, including extracellular vesicles including those referred to as exosomes, loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor. Methods of treating neurological diseases, disorders or conditions using the extracellular vesicles are provided. Isolated extracellular vesicles loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor are provided as well.

Abstract: The present invention provides methods and systems for enhanced production and/or secretion of extracellular vesicles (EVs) from muscle cells utilizing various dynamic mechanical loading profiles thereon, cultured on three-dimensional (3D) scaffolds. The scaffolds may comprise a plurality of layers, wherein each layer comprises a plurality of elastic microfibers, and wherein the microfibers are aligned in parallel to a longitudinal axis and to each other. The elastic 3D scaffold may be configured to undergo dynamic mechanical loading profiles and support an expansion of a population of muscle cells cultured thereon into a 3D multi-layer structure of muscle cells, wherein said 3D multi-layer structure is configured to produce and/or secret extracellular vesicles into a medium.

Abstract: The present invention provides pharmaceutical compositions comprising membrane vesicles, including extracellular vesicles including those referred to as exosomes, loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor. Methods of treating neurological diseases, disorders or conditions using the extracellular vesicles are provided. Isolated extracellular vesicles loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor are provided as well.

Abstract: The present invention provides methods and systems for enhanced production and/or secretion of extracellular vesicles from at least one three-dimensional porous scaffold having a population of stem cells cultured thereon, utilizing various shear stress conditions on a variety of stem cells.

Abstract: The present invention provides pharmaceutical compositions comprising membrane vesicles, including extracellular vesicles including those referred to as exosomes, loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor. Methods of treating neurological diseases, disorders or conditions using the extracellular vesicles are provided. Isolated extracellular vesicles loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor are provided as well.

Abstract: The present invention provides a control system for use in digital printing, comprising: a host; multiple main control boards connected to the host, multiple sets of nozzle plates, wherein each set of nozzle plate respectively is connected to one main control board and to one set of nozzle. The present invention also provides a control method for use in digital printing, comprising: the host decomposing a job into multiple portions, and distributing each portion of the job to one main control board; the main control boards concurrently converting received portions of the job into pages and distributing the pages to a set of nozzle plates connected thereto; the nozzle plates converting the pages into printing data and driving the nozzle sets connected to the nozzle boards to print the printing data thereof. The present invention achieves the effect of improving processing performance of the control system.

Abstract: The present invention provides a control system for use in digital printing, comprising: a host; multiple main control boards connected to the host, multiple sets of nozzle plates, wherein each set of nozzle plate respectively is connected to one main control board and to one set of nozzle. The present invention also provides a control method for use in digital printing, comprising: the host decomposing a job into multiple portions, and distributing each portion of the job to one main control board; the main control boards concurrently converting received portions of the job into pages and distributing the pages to a set of nozzle plates connected thereto; the nozzle plates converting the pages into printing data and driving the nozzle sets connected to the nozzle boards to print the printing data thereof. The present invention achieves the effect of improving processing performance of the control system.