Patents by Inventor Shaowen Wang

Shaowen Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10259827
    Abstract: The disclosure provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein: Also provided are methods of making the compounds of Formula (I) and their methods of use.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: April 16, 2019
    Assignee: NOVARTIS AG
    Inventors: Jian Ding, Marie-Helene Larraufie, Deborah Rothman, Nik Savage, Shaowen Wang
  • Patent number: 10081810
    Abstract: The present invention provides a c-Rel-specific siRNA and its use for preventing and treating autoimmune psoriasis. In particular, the c-Rel-specific siRNAs have sequences as shown in SEQ ID Nos. 1-2 or SEQ ID Nos. 3-4. In the present invention, small interfering RNA (siRel) specific to c-Rel are employed to inhibit c-Rel biosynthesis, and prevent and treat autoimmune psoriasis by inhibiting inflammatory factors relating to IL-23/IL-17A inflammatory axis.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: September 25, 2018
    Assignees: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY, THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Qingguo Ruan, Youhai H. Chen, Tingting Fan, Yifan Ma, Lintao Cai, Shaowen Wang, Xiaochun Wan
  • Publication number: 20180127436
    Abstract: The disclosure provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein: Also provided are methods of making the compounds of Formula (I) and their methods of use.
    Type: Application
    Filed: November 8, 2017
    Publication date: May 10, 2018
    Inventors: Jian DING, Marie-Helene LARRAUFIE, Deborah ROTHMAN, Nik SAVAGE, Shaowen WANG
  • Publication number: 20180002698
    Abstract: The present invention provides a c-Rel-specific siRNA and its use for preventing and treating autoimmune psoriasis. In particular, the c-Rel-specific siRNAs have sequences as shown in SEQ ID Nos. 1-2 or SEQ ID Nos. 3-4. In the present invention, small interfering RNA (siRel) specific to c-Rel are employed to inhibit c-Rel biosynthesis, and prevent and treat autoimmune psoriasis by inhibiting inflammatory factors relating to IL-23/IL-17A inflammatory axis.
    Type: Application
    Filed: August 18, 2017
    Publication date: January 4, 2018
    Inventors: Qingguo RUAN, Youhai H. CHEN, Tingting FAN, Yifan MA, Lintao CAI, Shaowen WANG, Xiaochun WAN
  • Publication number: 20070082339
    Abstract: The invention relates to the use of gene and protein expression levels as a marker for HDAC inhibition. Also disclosed are in vivo and in vitro methods for screening a compound for HDAC inhibitory activity, as well as methods for monitoring the therapeutic efficacy of an HDAC inhibitor in a subject in vivo and for determining resistance to an HDAC inhibitor in vitro or in vivo.
    Type: Application
    Filed: October 7, 2005
    Publication date: April 12, 2007
    Inventors: Dalia Cohen, Shaowen Wang
  • Publication number: 20060040884
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of trapoxin A regulated genes, including but not limited to those genes induced by ectopic expression of p21waf1 that are disclosed herein. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding these genes. Methods of using these compounds for modulation of expression of these genes and for treatment of diseases associated with these genes, as well as those associated with abnormal HDAC activity, particularly cancer or others characterized by abnormal cell proliferation, are provided. Furthermore, the invention relates to the use of RhoB as a biomarker to evaluate the efficacy of treatment of humans with abnormal HDAC activity including proliferative diseases such as cancer.
    Type: Application
    Filed: July 28, 2005
    Publication date: February 23, 2006
    Inventors: Francis Buxton, Dalia Cohen, Denise Fischer, Shaowen Wang