Abstract: The present application relates to an antigen-binding polypeptide that specifically binds to B7H3, comprising at least one complementarity-determining region (CDR) of an antibody heavy chain variable region (VH), wherein the VH comprises an amino acid sequence set forth in SEQ ID NO: 25. The present application further relates to a chimeric antigen receptor comprising the antigen-binding polypeptide and a universal CAR-T cell comprising the chimeric antigen receptor. The CAR-T cell recognizes a surface antigen of a tumor cell and knocks out TCR and HLA-A genes expressed by the cell at the same time, so that the immune rejection caused by an allogeneic CAR-T therapy is reduced, the survival time of the cell is prolonged, and the anti-tumor effect is improved.

Abstract: The present application discloses an antenna structure and a terminal device. The antenna structure includes: a resonant branch, a coupling branch, a coupling metal body, and a feeding structure. The resonant branch is provided with a feeding point, one end of the resonant branch is coupled to the coupling branch through a gap, the other end of the resonant branch is grounded through a first grounding point, one end of the coupling branch is coupled to the resonant branch through the gap, the other end of the coupling branch is grounded through a second grounding point, the coupling metal body is suspended in air and is respectively coupled to the resonant branch and the coupling branch, one end of the feeding structure is connected to the feeding point of the resonant branch, and the other end of the feeding structure is grounded.

Abstract: A pixel scan drive circuit including a switch unit, a pull-up output unit and a pull-down output unit is provided. In a scan signal output phase of a scanning cycle, the pull-down output unit outputs a first reference voltage in a scan signal to an output end according to a clock signal. In a maintenance phase of the scanning cycle, the switch unit controls the voltage of a pull-down node according to a switch control signal, thereby controlling the pull-down output unit to stop outputting the first reference voltage. In the maintenance phase, the pull-up output unit outputs a second reference voltage in the scan signal. The second reference voltage controls the pixel units to stop receiving the image data. Transistors in the switch unit are of different types from transistors in the pull-up output unit and the pull-down output unit. An array substrate and a display terminal are provided.

Abstract: The present application relates to a touch display panel and an electronic device. The touch display panel includes: a substrate; and a light-emitting unit layer locating on a side of the substrate comprising a cathode metal layer reused as a touch electrode layer and multiple light-emitting units arranged in an array; the light-emitting units each have a light-emitting cycle comprising a first time period and a second time period staggered from the first time period; the cathode metal layer accesses a touch drive signal when the light-emitting cycle is within the first time period, and the cathode metal layer accesses a display drive signal when the light-emitting cycle is within the second time period. The cathode metal layer according to the present application is reused as the touch electrode layer, and inputs different drive signals in different time periods, which can greatly reduce a thickness of the touch display panel.

Abstract: The present disclosure discloses an electronic device, including backplane circuits, a plurality of conductive adhesive elements arranged on the backplane circuits at intervals, and a plurality of electronic components arranged on the plurality of conductive adhesive elements respectively. The backplane circuits are respectively electrically connected with the plurality of electronic components through the plurality of conductive adhesive elements. The present disclosure further discloses a manufacturing method used for manufacturing the above electronic device.

Abstract: GOA unit and GOA circuit thereof, and display device. The GOA unit comprises a pull-up control module, a turn-on module, a pull-down and holding module, and a bootstrap capacitor, where an output end of the pull-up control module is connected to an input end of the turn-on module, an input end of the pull-down and holding module, and one end of the bootstrap capacitor; the input end of the turn-on module is connected to one end of the bootstrap capacitor, an output end of the turn-on module is connected to the other end of the bootstrap capacitor and an output end of the pull-down and holding module, the output end of the turn-on module is an output end of the GOA unit, the turn-on module and the pull-down and holding module include different types of thin film transistors, so a narrow bezel and a good display quality can be implemented.

Abstract: This disclosure provides a non-planar display apparatus including a substrate and a plurality of light-emitting elements, the substrate is non-planar and includes a plurality of pixel islands; a spacing is formed between each pair of the plurality of pixel islands, the plurality of pixel islands are mechanically connected, and each pixel island is surrounded by a plurality of spacings; the plurality of pixel islands support subsets of light-emitting elements among the plurality of light-emitting elements, respectively; herein, the plurality of pixel islands form a non-planar surface.

Abstract: A pixel scan drive circuit including a switch unit, a pull-up output unit and a pull-down output unit is provided. In a scan signal output phase of a scanning cycle, the pull-down output unit outputs a first reference voltage in a scan signal to an output end according to a clock signal. In a maintenance phase of the scanning cycle, the switch unit controls the voltage of a pull-down node according to a switch control signal, thereby controlling the pull-down output unit to stop outputting the first reference voltage. In the maintenance phase, the pull-up output unit outputs a second reference voltage in the scan signal. The second reference voltage controls the pixel units to stop receiving the image data. Transistors in the switch unit are of different types from transistors in the pull-up output unit and the pull-down output unit. An array substrate and a display terminal are provided.

Abstract: The disclosure provides a pixel unit. The pixel unit includes a pixel circuit. The pixel circuit includes a data writing unit, a driving unit, a display unit, a compensation unit and a reset unit. The reset unit is electrically connected with at least one of the display unit and the driving unit. The reset unit is electrically connected with the scan drive line to receive a scan signal, and is operable to write, according to the reset signal, a scan voltage of the scan signal as the reset voltage into at least one of the display unit and the driving unit during a reset time period. The scan signal is the first scan signal or a first scan signal of a next pixel unit. The disclosure also provides a display panel and an electronic device.

Abstract: The disclosure provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein: Also provided are methods of making the compounds of Formula (I) and their methods of use.

Abstract: The disclosure provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein: Also provided are methods of making the compounds of Formula (I) and their methods of use.

Abstract: The present invention provides a c-Rel-specific siRNA and its use for preventing and treating autoimmune psoriasis. In particular, the c-Rel-specific siRNAs have sequences as shown in SEQ ID Nos. 1-2 or SEQ ID Nos. 3-4. In the present invention, small interfering RNA (siRel) specific to c-Rel are employed to inhibit c-Rel biosynthesis, and prevent and treat autoimmune psoriasis by inhibiting inflammatory factors relating to IL-23/IL-17A inflammatory axis.

Abstract: The disclosure provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein: Also provided are methods of making the compounds of Formula (I) and their methods of use.

Abstract: The present invention provides a c-Rel-specific siRNA and its use for preventing and treating autoimmune psoriasis. In particular, the c-Rel-specific siRNAs have sequences as shown in SEQ ID Nos. 1-2 or SEQ ID Nos. 3-4. In the present invention, small interfering RNA (siRel) specific to c-Rel are employed to inhibit c-Rel biosynthesis, and prevent and treat autoimmune psoriasis by inhibiting inflammatory factors relating to IL-23/IL-17A inflammatory axis.

Abstract: The invention relates to the use of gene and protein expression levels as a marker for HDAC inhibition. Also disclosed are in vivo and in vitro methods for screening a compound for HDAC inhibitory activity, as well as methods for monitoring the therapeutic efficacy of an HDAC inhibitor in a subject in vivo and for determining resistance to an HDAC inhibitor in vitro or in vivo.

Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of trapoxin A regulated genes, including but not limited to those genes induced by ectopic expression of p21waf1 that are disclosed herein. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding these genes. Methods of using these compounds for modulation of expression of these genes and for treatment of diseases associated with these genes, as well as those associated with abnormal HDAC activity, particularly cancer or others characterized by abnormal cell proliferation, are provided. Furthermore, the invention relates to the use of RhoB as a biomarker to evaluate the efficacy of treatment of humans with abnormal HDAC activity including proliferative diseases such as cancer.