Abstract: A method for incremental crawling of content stored on a plurality of content providers using aggregation is provided. The method comprises receiving a request to crawl content on one or more associated content providers; retrieving one or more first references to content on a first content provider; retrieving one or more second references to content on one or more second content providers during the same request; aggregating the first and second references; and returning the aggregated first and second references. This is done while taking into consideration opaque timestamp object which is managed in a distributed manner. The opaque timestamp is filled in by the content providers but stored in the crawler side between crawling sessions.

Abstract: A device for unblocking an occlusion (3) in an occluded vessel (2) comprises a catheter (5) having an inflatable balloon (19) located at a distal leading end (8) thereof so that by inflating the balloon (19) the leading end of the catheter (5) may be anchored in the occluded vessel (2) or in a vessel adjacent the occluded vessel (2) with the leading end adjacent the occlusion (3). A guide wire (12) terminating in a pointed distal tip (18) is urgeable through a bore (10) in the catheter (5) for engaging and penetrating through the occlusion (3).

Abstract: The presently described technology relates to acyl lactylate containing compositions having improved stability and multifunctional performance characteristics (e.g., pH stability, phase stability, hydrolytic stability (e.g., aqueous stability), cleansing, foaming, skin softness and skin moisturization) that may be utilized in rinse-out and leave-on skin and hair applications. The acyl lactylate compositions of the present technology may be delivered to the skin or hair via a conventional delivery vehicle such as a body wash, a shampoo, a bubble bath, a skin cream, or a lotion.

Abstract: A CT scanner with scatter correction device and a method for scatter correction are provided. The method of correcting CT images from artifacts caused by scattered radiation comprises affixing to the non-rotating frame of the CT gantry a plurality of shields for shielding some of the CT detector elements from direct X ray radiation, while allowing scattered radiation to arrive at said shielded elements; measuring scatter signals from said shielded elements, indicative of scattered radiation intensity; and correcting for scatter by subtracting scatter intensity values estimated from said measured scatter signals from signals measured by unshielded detector elements.

Abstract: Disclosed is a method for preparing a compound of Formula 1 by contacting compound of Formula 2 with R1—NH2 in the presence of a carboxylic acid and a method for preparing a compound of Formula 2 by contacting a compound of Formula 4 with phosphorus tribromide. wherein R1 is H, C1-C4 alkyl, cyclopropyl, cyclopropylmethyl or methylcyclopropyl; R2 is CH3 or Cl; R3 is C1-C6 alkyl or C3-C6 alkenyl, each optionally substituted with up to 3 halogen and up to 1 phenyl; and X is Cl or Br. Also disclosed is a method for preparing a compound of Formula 5 wherein R4, R5, R6 and Z are as defined in the disclosure, using a compound of Formula 1 that is characterized by preparing the compound of Formula 1 by the method above.

Abstract: A refrigeration system includes a primary compressor that receives refrigerant from an evaporator and delivers refrigerant to a condenser, a subcooling compressor that delivers refrigerant to the condenser, and a subcooler that receives refrigerant from the condenser. A first refrigerant flow path and a second refrigerant flow path pass through the subcooler. The first refrigerant flow path delivers a portion of the refrigerant to the evaporator, and the second refrigerant flow path delivers a remainder of the refrigerant to the subcooling compressor. The refrigeration system includes a controller operable to control operation of the subcooling compressor such that the refrigeration system operates at a point of highest efficiency.

Abstract: The present invention provides compositions and methods for modulating cellular nitric oxide (NO) production and for treating a clinical condition associated therewith.

Abstract: A combination lantern and insect repellent dispensing apparatus. Light is produced by light bulbs or LEDs whereas insect repellent is dispensed by heating a volatilizable insecticide The insecticide and portable light may be used either concurrently or independently of each other.

Abstract: Systems and methods for conducting a multi-endpoint video signal conference are provided. Conferencing endpoints are linked by pairs of a reliable and a less reliable communication channel. Conference video signals are scaleable coded in base layer and enhancement layers format. Video signal base layers, which correspond to a minimum picture quality, are communicated over reliable channels. The video signal enhancements layers may be communicated over the less reliable channels. A conference server mediates the switching of video layer information from transmitting endpoints to receiving endpoints without any intermediate coding or re-coding operations. The video conference can be integrated with an audio conference using either scalable coded audio signals or non-scaleable coded audio signals.

Abstract: Provided herein are compounds and methods of using compounds that selectively inhibit binding to one or more docking domain regions of an extracellular signal-recognition kinase to inhibit in a cell having an extracellular signal-regulated kinase activity. Such methods may be used to inhibit cell proliferation of a neoplastic cell, to treat a cancer and further may be used in conjunction with administration of an anticancer drug at a reduced dosage to treat a cancer with a concomitant reduction in toxicity to an individual receiving the treatment. Also provided is a method to design and screen for compounds to inhibit binding within the extracellular signal-regulated kinase docking domain region, using at least in part computer-aided drug design modeling.

Abstract: Tetrasubstituted benzenes that act as modulators of gamma secretase and their use in the treatment of one or more symptoms of treating neurodegenerative disorders, e.g., Alzheimer's disease, are described.

Abstract: A receiver that provides interference cancellation in conjunction with RAKE processing. Signal parameters corresponding to each of a plurality of fingers corresponding to RAKE processing are maintained. Synthesized pilot signals are estimated using the signal parameters by interpolating waveforms for respective ones of the plurality of synthesized pilot signals to a common sampling lattice of the received set of data, and are then cancelled out. According to another aspect, a receiver ensures completion of a time-critical process such as signal demodulation and adaptively applies a non-time-critical process such as interference cancellation to the extent that computational resources become available subject to ensuring the completion of the time-critical process.

Abstract: Phase-conjugate optical coherence tomography (PC-OCT) methods and apparatus. PC-OCT may be employed as a three-dimensional imaging technique of interest for biomedical and other imaging applications. It shares much of the source and detection convenience of conventional OCT employing classical light sources, which is in clinical use in ophthalmology and is being developed for a variety of endoscopic optical biopsy instruments. PC-OCT offers a two-fold improvement in axial resolution and immunity to group velocity dispersion, when compared with conventional OCT, that is available from quantum optical coherence tomography (Q-OCT). PC-OCT does this without Q-OCT's need for a non-classical light source and the attendant requirement of photon-coincidence counting detection. Thus, in comparison with Q-OCT, PC-OCT is capable of producing images in measurement times similar to those of conventional OCT.

Abstract: The disclosure herein relates to nuclear hormone receptors including steroid hormone receptors, for example in connection with estrogen, progesterone, and androgen. Embodiments of compositions and methods are disclosed including such relating to compounds, including substituted theophyllines, capable of functioning as inhibitors of estrogen receptor alpha-mediated gene expression and having the ability to modify cancer cells and treat cancer, including breast cancers and resistant breast cancers, particularly those that are resistant to tamoxifen. In embodiments, methods of inhibiting breast cancer cells and resistant breast cancer cells are provided. In embodiments, a useful inhibitor compound includes TPSF/NSC 97998 and other compounds.

Abstract: A method of generating a cell lineage tree of a plurality of cells of an individual is provided. The method comprising: (a) determining at least one genotypic marker for each cell of the plurality of cells; and (b) computationally clustering data representing the at least one genotypic marker to thereby generate the cell lineage tree of the plurality of cells of the individual.

Abstract: A process that ensures the virtual destruction of data files a user wishes to erase from a storage medium, such as a hard drive, flash drive, or removable disk. This approach is appropriate for managing custom distributions from a large file sets as it is roughly linear in compute complexity to the number of files erased but is capped when many files are batch erased.

Abstract: Systems and methods are disclosed for directing magnetizable particles comprising therapeutic agents to a target volume, or for guiding magnetizable particles comprising therapeutic agents from a first target volume to a second target volume, at a distance using a magnetic field, to enable the treatment of diseased areas including areas deep inside a patient's body. The methods may be used to diagnose or treat diseased areas within a patient, for example tumors of the lungs, intestines, and liver, and is also useful in enhancing the permeability of solid tumors to chemotherapeutic agents.

Abstract: A refrigeration system including a refrigeration circuit and a controller. The refrigeration circuit includes a plurality of variable capacity compressors arranged in parallel to compress a refrigerant. A second variable capacity compressor is started after a first variable capacity compressor. An evaporator defines a load while evaporating the refrigerant to refrigerate a space within a predetermined temperature range. The controller is programmed to control the operation of the plurality of variable capacity compressors to match the capacity of the plurality of variable capacity compressors to the load by increasing the capacity of the last compressor in the queue of running compressors when the capacity of the plurality of variable capacity compressors is lower than the load and by decreasing the capacity of the first compressor in the queue when the capacity of the plurality of variable capacity compressors is higher than the load.

Abstract: An exercise device is provided for simulating the paddling of a watercraft in order to provide a user with both aerobic and anaerobic exercise. In one aspect, an elongate rod is provided having a first assembly coupled to a distal end of the elongate rod. The first assembly can have at least two degrees of freedom and can be configured for selectively attaching to a resistance source. In another aspect, the device further can have a second assembly attached to a proximal end of the elongate rod. The second assembly can have at least two degrees of freedom and can be configured for selectively attaching to a resistance source.