Patents by Inventor Sharad P. Adekar

Sharad P. Adekar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of making hybrid cells that express useful antibodies
    Patent number: 8999707
    Abstract: This invention relates to a novel hybridoma strategy that uses CD27+ B cells cultured in vitro to induce IgM to IgG class switch prior to fusion with a fusion partner. Hybridomas resulting from the fusion between CD27+ B cells and a fusion partner cell line and antibodies secreted from the hybridomas are included in the invention.
    Type: Grant
    Filed: January 28, 2009
    Date of Patent: April 7, 2015
    Assignee: Thomas Jefferson University
    Inventors: Scott K. Dessain, Sharad P. Adekar
  • Fusion partner cell line for preparation of hybrid cells expressing human antibodies
    Patent number: 8557575
    Abstract: This invention relates to a novel fusion partner cell line that ectopically expresses IL-6 and TERT termed B5-6T, and to methods for making the B5-6T fusion partner cell line. The B5-6T fusion partner cell line can be fused with B-lymphocytes to generate hybridomas that secrete human monoclonal antibodies.
    Type: Grant
    Filed: January 28, 2009
    Date of Patent: October 15, 2013
    Assignee: Thomas Jefferson University
    Inventors: Scott K. Dessain, Sharad P. Adekar
  • FUSION PARTNER CELL LINE FOR PREPARATION OF HYBRID CELLS EXPRESSING HUMAN ANTIBODIES
    Publication number: 20110008344
    Abstract: This invention relates to a novel fusion partner cell line that ectopically expresses IL-6 and TERT termed B5-6T, and to methods for making the B5-6T fusion partner cell line. The B5-6T fusion partner cell line can be fused with B-lymphocytes to generate hybridomas that secrete human monoclonal antibodies.
    Type: Application
    Filed: January 28, 2009
    Publication date: January 13, 2011
    Applicant: THOMAS JEFFERSON UNIVERSITY
    Inventors: Scott K. Dessain, Sharad P. Adekar
  • METHOD OF MAKING HYBRID CELLS THAT EXPRESS USEFUL ANTIBODIES
    Publication number: 20110002937
    Abstract: This invention relates to a novel hybridoma strategy that uses CD27+ B cells cultured in vitro to induce IgM to IgG class switch prior to fusion with a fusion partner. Hybridomas resulting from the fusion between CD27+ B cells and a fusion partner cell line and antibodies secreted from the hybridomas are included in the invention.
    Type: Application
    Filed: January 28, 2009
    Publication date: January 6, 2011
    Applicant: THOMAS JEFFERSON UNIVERSITY
    Inventors: Scott K. Dessain, Sharad P. Adekar
  • Monoclonal antibodies that neutralize botulinum neurotoxin
    Publication number: 20100222555
    Abstract: This invention provides antibodies that specifically bind to botulinum neurotoxin type A (BoNT/A) and/or botulinum neurotoxin type B (BoNT/B) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism. Also included in the invention are diagnostic and therapeutic assays directed to botulinum neurotoxins.
    Type: Application
    Filed: June 19, 2006
    Publication date: September 2, 2010
    Applicant: Thomas Jefferson University
    Inventors: Scott K. Dessain, Lance L. Simpson, Sharad P. Adekar