Patents by Inventor Sharadsrikar KOTTURI
Sharadsrikar KOTTURI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230272448Abstract: The present invention relates to obtaining single incubation condition for cocktail of probe substrates of 8 major Cytochrome P450 (CYP) isoforms to assess in vitro drug-drug interactions (DDIs) of novel drug candidates using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) method. The present invention provides an improved and reduced substrate concentration and is developed in lower microsomal protein to avoid any non-specific binding of substrates with the microsomal proteins.Type: ApplicationFiled: July 30, 2021Publication date: August 31, 2023Applicant: PIRAMAL PHARMA LIMITEDInventors: Vinod SANNA, Sharadsrikar KOTTURI, Mahendra SHUKLA, Mohammed Salauddin SHAIKH, Himani SAMAR
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Patent number: 11401273Abstract: The present invention relates to an improved asymmetric synthesis of azaspiro or diazaspiro compound (hereafter referred to as the compound 5, (5A) or (5N)) or their pharmaceutically acceptable salts and derivatives; through the formation of intermediate compounds 4, (4A) or (4N) respectively. The process comprises an unusual substrate specific highly diastereoselective as well as enantio-enriched 1-substituted 2-azaspiro[3.3]heptane or 1-substituted 2-diazaspiro[3.3]heptane compounds with high diastereoselectivity by addition of a cyclobutane carboxylate anion to a Davis-Ellman's imine, followed by reduction and cyclisation resulting in the selective formation of azaspiro or diazaspiro intermediate compound 4, (4A) or (4N); which on subsequently removing the sulfinyl group provides corresponding azaspiro or diazaspiro compound 5, (5A) or (5N) respectively.Type: GrantFiled: November 19, 2019Date of Patent: August 2, 2022Assignee: PIRAMAL PHARMA LIMITEDInventors: Rajender Reddy Leleti, Yogesh Waman, Priya Kallure, Zubeda Begum, Thumban Divya, Kumara Swamy Nalivela, Saurabh Vijay, Paranjay Parikh, Sharadsrikar Kotturi, Chirag Patel, Krishna Nayak, Kasimraza Baharooni, Vinkal Zalavadiya
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Publication number: 20220185788Abstract: The present invention relates to an improved process for the preparation of N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)octanamide (A), which is known as ELIGLUSTAT and its pharmaceutically acceptable salts, comprising the formation of novel intermediate metal complex (III), which on hydrolysis in presence of acid provides amine compound (IV) (as described herein), which is treated with pyrrolidine and subsequently reduced to convert into Eliglustat (A).Type: ApplicationFiled: March 19, 2020Publication date: June 16, 2022Applicant: PIRAMAL PHARMA LIMITEDInventors: Venkataramana Rao RAO, Sharadsrikar KOTTURI, Abdul BASITH, Ramesh Babu BANDI, Manoj Kumar MANDADI
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Patent number: 11299455Abstract: The present invention relates to an improved process for diastereoselective synthesis of vicinal diamines (1). The process involves highly regio- and diastereoselective addition of 2-azaallyl anions (4) to N-tert-butanesulfinylimines (5) to produce vicinal diamines (1).Type: GrantFiled: July 11, 2019Date of Patent: April 12, 2022Assignee: PIRAMAL PHARMA LIMITEDInventors: Rajender Reddy Leleti, Sharadsrikar Kotturi, Kumara Swamy Nalivela, Chirag Patel, Poojabahen Raval, Vinkal Zalavadiya
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Patent number: 11279672Abstract: The present invention relates to an improved asymmetric synthesis of alpha-branched amines (hereafter referred to as the compound) and relative chiral amines (1?) or its pharmaceutically acceptable salt and derivatives. The process comprises an unusual substrate specific regioselective ortho lithiation of substituted arene compounds, followed by its highly diastereoselective addition to N-tert-butanesulfinylimines resulting in the selective formation of alpha-branched sulfinyl amine and chiral amine; which on subsequently removing the sulfinyl group provides corresponding alpha-branched amines or relative chiral amines (1?).Type: GrantFiled: April 17, 2019Date of Patent: March 22, 2022Assignee: PIRAMAL PHARMA LIMITEDInventors: Rajender Reddy Leleti, Sharadsrikar Kotturi, Yogesh Waman, Chirag Patel, Aditya Patwa, Rajesh Shenoy
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Patent number: 11279668Abstract: The present invention relates to an improved asymmetric synthesis of alpha-(diarylmethyl) alkyl amines (hereafter referred to as the compound (1)) or its pharmaceutically acceptable salt and derivatives. The process comprises an unusual substrate specific regioselective lithiation of alpha-diarylmethanes. followed by its highly diastereoselective addition to N-tert-butanesulfinylimines resulting in the selective formation of chiral alpha-(diarylmethyl) alkyl amines 4 and chiral amine 5; which on subsequently removing the sulfinyl group provides corresponding alpha-(diarylmethyl) alkyl amines (1) or relative chiral amines (1?).Type: GrantFiled: March 20, 2019Date of Patent: March 22, 2022Assignee: PIRAMAL PHARMA LIMITEDInventors: Rajender Reddy Leleti, Sharadsrikar Kotturi, Yogesh Waman, Chirag Patel, Rajesh Shenoy
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Publication number: 20220073454Abstract: The present invention relates to an improved process for diastereoselective synthesis of vicinal diamines (1). The process involves highly regio- and diastereoselective addition of 2-azaallyl anions (4) to N-tert-butanesulfinylimines (5) to produce vicinal diamines (1).Type: ApplicationFiled: July 11, 2019Publication date: March 10, 2022Applicant: PIRAMAL PHARMA LIMITEDInventors: Rajender Reddy LELETI, Sharadsrikar KOTTURI, Kumara Swamy NALIVELA, Chirag PATEL, Poojabahen RAVAL, Vinkal ZALAVADIYA
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Publication number: 20220041609Abstract: The present invention relates to an improved asymmetric synthesis of azaspiro or diazaspiro compound (hereafter referred to as the compound 5, (5A) or (5N)) or their pharmaceutically acceptable salts and derivatives; through the formation of intermediate compounds 4, (4A) or (4N) respectively. The process comprises an unusual substrate specific highly diastereoselective as well as enantio-enriched 1-substituted 2-azaspiro[3.3]heptane or 1-substituted 2-diazaspiro[3.3]heptane compounds with high diastereoselectivity by addition of a cyclobutane carboxylate anion to a Davis-Ellman's imine, followed by reduction and cyclisation resulting in the selective formation of azaspiro or diazaspiro intermediate compound 4, (4A) or (4N); which on subsequently removing the sulfinyl group provides corresponding azaspiro or diazaspiro compound 5, (5A) or (5N) respectively.Type: ApplicationFiled: November 19, 2019Publication date: February 10, 2022Applicant: PIRAMAL PHARMA LIMITEDInventors: Rajender Reddy LELETI, Yogesh WAMAN, Priya KALLURE, Zubeda BEGUM, Thumban DIVYA, Kumara Swamy NALIVELA, Saurabh VIJAY, Paranjay PARIKH, Sharadsrikar KOTTURI, Chirag PATEL, Krishna NAYAK, Kasimraza BAHAROONI, Vinkal ZALAVADIYA
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Publication number: 20210371992Abstract: The present invention provides to a simple and efficient electrochemical organic reaction setup, particularly to carry out electrolysis reactions in chemistry laboratory and methods for performing the same with good yield and less impurity formation using the instantly presented device. Accordingly, the present invention relates to an electrochemical organic reaction setup as shown in fig. A-J comprising (a) Current source (6), (b) Reaction vessel or vial assembly set up comprising reaction vessel or vial (3), anode (1) cathode (2), Guard tube (8), alligator clip (5) and (c) Reaction mixture (4); for use in electrochemical reactions involving coupling between carbocyclic or heterocyclic rings and also in ring formation reactions between two or more moieties.Type: ApplicationFiled: November 20, 2019Publication date: December 2, 2021Applicant: PIRAMAL PHARMA LIMITEDInventors: Tanay GHOSAL, Vishal NAGAR, Sharadsrikar KOTTURI, Sasikumar KUTTAAPPAN
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Publication number: 20210229063Abstract: The present invention provides an improved photochemical rector assembly device, particularly a light emitting diode (LED) based small photochemical reactor and methods for performing the photochemical transformations using the instantly presented device. Accordingly, the present invention relates to an improved photochemical transformation reaction by exposing the reaction mixture to a photochemical rector device as shown in fig. A-G, comprising of (i) light emitting diode (LED) panel (1), (ii) Aluminium based heat sink, and (iii) cooling fan.Type: ApplicationFiled: August 19, 2019Publication date: July 29, 2021Applicant: PIRAMAL PHARMA LIMITEDInventors: Tushar PATEL, Sharadsrikar KOTTURI, Sasikumar KUTTAPPAN
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Publication number: 20210114977Abstract: The present invention relates to an improved asymmetric synthesis of alpha-branched amines (hereafter referred to as the compound) and relative chiral amines (1?) or its pharmaceutically acceptable salt and derivatives. The process comprises an unusual substrate specific regioselective ortho lithiation of substituted arene compounds, followed by its highly diastereoselective addition to N-tert-butanesulfinylimines resulting in the selective formation of alpha-branched sulfinyl amine and chiral amine; which on subsequently removing the sulfinyl group provides corresponding alpha-branched amines or relative chiral amines (1?).Type: ApplicationFiled: April 17, 2019Publication date: April 22, 2021Applicant: PIRAMAL ENTERPRISES LIMITEDInventors: Rajender Reddy LELETI, Sharadsrikar KOTTURI, Yogesh WAMAN, Chirag PATEL, Aditya PATWA, Rajesh SHENOY
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Publication number: 20210061752Abstract: The present invention relates to an improved asymmetric synthesis of alpha-(diarylmethyl) alkyl amines (hereafter referred to as the compound (1)) or its pharmaceutically acceptable salt and derivatives. The process comprises an unusual substrate specific regioselective lithiation of alpha-diarylmethanes, followed by its highly diastereoselective addition to N-tert-butanesulfinylimines resulting in the selective formation of chiral alpha-(diarylmethyl) alkyl amines 4 and chiral amine 5; which on subsequently removing the sulfinyl group provides corresponding alpha-(diarylmethyl) alkyl amines (1) or relative chiral amines (1?).Type: ApplicationFiled: March 20, 2019Publication date: March 4, 2021Applicant: PIRAMAL ENTERPRISES LIMITEDInventors: Rajender Reddy LELETI, Sharadsrikar KOTTURI, Yogesh WAMAN, Chirag PATEL, Rajesh SHENOY