Abstract: The disclosure provides a method and system for optimizing production of a natural gas liquefaction process, the method comprising the steps of: selecting at least one manipulated variable (MV) for controlling the liquefaction process; selecting at least one control variable (CV), the at least one control variable at least comprising liquefied natural gas (LNG) throughput; providing at least one model, each model providing a dependency of the at least one control variable (CV) on the at least one manipulated variable (MV); using the at least one model to estimate LNG throughput for at least one of the manipulated variables (MV); obtaining process data from the liquefaction process, the process data at least including observed values of LNG throughput; creating a gain matrix based on said interdependencies; and using the gain matrix to optimize a process control system of the liquefaction process.