Patents by Inventor Sharat Singh

Sharat Singh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ULTRA BRIGHT DIMERIC OR POLYMERIC DYES
    Publication number: 20190016898
    Abstract: Compounds useful as fluorescent or colored dyes are disclosed. The compounds have the following structure (I): or a stereoisomer, tautomer or salt thereof, wherein R1, R2, R3, R4, R5, L1, L2, L3, L4, M, m and n are as defined herein. Methods associated with preparation and use of such compounds are also provided.
    Type: Application
    Filed: March 31, 2017
    Publication date: January 17, 2019
    Inventors: Tracy Matray, Sharat Singh, Michael VanBrunt
  • PATHWAY SPECIFIC MARKERS FOR DIAGNOSING IRRITABLE BOWEL SYNDROME
    Publication number: 20180321259
    Abstract: The present invention provides methods for aiding in the diagnosis of irritable bowel syndrome (IBS) in an individual. In particular, the present invention is useful for determining whether the individual does not have either celiac disease or inflammatory bowel disease (IBD), and has IBS and/or a subtype thereof. Thus, the present invention provides an accurate diagnostic prediction of IBS and is useful for guiding treatment decisions.
    Type: Application
    Filed: June 29, 2018
    Publication date: November 8, 2018
    Applicant: Nestec S.A.
    Inventors: Stefan Westin, Fabiyola Selvaraj, Fred Princen, Sharat Singh
  • ADDRESSABLE ANTIBODY ARRAYS AND METHODS OF USE
    Publication number: 20180321254
    Abstract: Systems and assay methods are disclosed for detecting an autoantibody in a sample. In certain instances, the systems and methods employ a mass tag releasably connected to an antigen. The tag is thereafter released for detection. A tag can be detected by mass spectrometry or in certain instances the tag is fluorescent. Methods for diagnosing a disease or disorder in a subject are also disclosed.
    Type: Application
    Filed: July 16, 2018
    Publication date: November 8, 2018
    Applicant: Nestec S.A.
    Inventors: Sharat Singh, Shui Long Wang
  • Methods of disease activity profiling for personalized therapy management
    Patent number: 10086072
    Abstract: The present invention provides methods for personalized therapeutic management of a disease in order to optimize therapy and/or monitor therapeutic efficacy. In particular, the present invention comprises measuring an array of one or a plurality of biomarkers at a plurality of time points over the course of therapy with a therapeutic agent to determine a mucosal healing index for selecting therapy, optimizing therapy, reducing toxicity, and/or monitoring the efficacy of therapeutic treatment. In certain instances, the therapeutic agent is a TNF? inhibitor for the treatment of a TNF?-mediated disease or disorder.
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: October 2, 2018
    Assignee: Nestec S.A.
    Inventors: Sharat Singh, Nicholas Hoe, Steve Lockton, Scott Hauenstein, Linda Ohrmund
  • Addressable antibody arrays and methods of use
    Patent number: 10036757
    Abstract: Systems and assay methods are disclosed for detecting an autoantibody in a sample. In certain instances, the systems and methods employ a mass tag releasably connected to an antigen. The tag is thereafter released for detection. A tag can be detected by mass spectrometry or in certain instances the tag is fluorescent. Methods for diagnosing a disease or disorder in a subject are also disclosed.
    Type: Grant
    Filed: October 1, 2012
    Date of Patent: July 31, 2018
    Assignee: Nestec S.A.
    Inventors: Sharat Singh, Shui Long Wang
  • Pathway specific markers for diagnosing irritable bowel syndrome
    Patent number: 10036759
    Abstract: The present invention provides methods for aiding in the diagnosis of irritable bowel syndrome (IBS) in an individual. In particular, the present invention is useful for determining whether the individual does not have either celiac disease or inflammatory bowel disease (IBD), and has IBS and/or a subtype thereof. Thus, the present invention provides an accurate diagnostic prediction of IBS and is useful for guiding treatment decisions.
    Type: Grant
    Filed: July 11, 2017
    Date of Patent: July 31, 2018
    Assignee: Nestec S.A.
    Inventors: Stefan Westin, Fabiyola Selvaraj, Fred Princen, Sharat Singh
  • GASTROINTESTINAL TRACT DETECTION METHODS, DEVICES AND SYSTEMS
    Publication number: 20180206726
    Abstract: The present disclosure relates to gastrointestinal (GI) tract detection methods, devices and systems.
    Type: Application
    Filed: December 7, 2017
    Publication date: July 26, 2018
    Inventors: Sharat Singh, Mitchell Lawrence Jones
  • Ingestible Device and Associated Methods
    Publication number: 20180168489
    Abstract: An ingestible device is disclosed which can produce spectral data of one or more analytes, as well as associated methods for characterizing the gastrointestinal tract of a subject which contains such analytes. Related kits and systems are also disclosed.
    Type: Application
    Filed: December 15, 2017
    Publication date: June 21, 2018
    Inventors: Ryan Elliott Jones, Hamilton Roger Tang, Rachel Ellen Gerver, Mitchell Lawrence Jones, Sharat Singh
  • ULTRA BRIGHT DIMERIC OR POLYMERIC DYES WITH SPACING LINKER GROUPS
    Publication number: 20180164322
    Abstract: Compounds useful as fluorescent or colored dyes are disclosed. The compounds have the following structure (I): or a stereoisomer, tautomer or salt thereof, wherein R1, R2, R3, R4, R5, L1, L2, L3, L4, M, m and n are as defined herein. Methods associated with preparation and use of such compounds are also provided.
    Type: Application
    Filed: November 1, 2017
    Publication date: June 14, 2018
    Inventors: Tracy Matray, Sharat Singh
  • GASTROINTESTINAL TRACT DETECTION METHODS, DEVICES AND SYSTEMS
    Publication number: 20180164221
    Abstract: The present disclosure relates to gastrointestinal (GI) tract detection methods, devices and systems.
    Type: Application
    Filed: December 7, 2017
    Publication date: June 14, 2018
    Inventors: Sharat Singh, Mitchell Lawrence Jones, Christopher Loren Wahl
  • PATHWAY SPECIFIC ASSAYS FOR PREDICTING IRRITABLE BOWEL SYNDROME DIAGNOSIS
    Publication number: 20180136233
    Abstract: The present invention provides antibodies and methods for preparing antibodies to metabolites in the serotonin, tryptophan, kynurenine pathways. The prepared antibodies have low cross-reactivity to related metabolites, and are useful reagents for specific and sensitive immunoassays The present invention also provides stable derivatives of various metabolites and short chain fatty acids. The derivative can be conjugated to a biomolecule such as a carrier protein and combined with an adjuvant to stimulate an immune response. The derivatives can also be conjugated to other biomolecules.
    Type: Application
    Filed: December 19, 2017
    Publication date: May 17, 2018
    Applicant: Nestec S.A.
    Inventors: Fabiyola Selvaraj, Fred Princen, Sharat Singh
  • Methods and compositions for analyzing proteins
    Patent number: 9939447
    Abstract: Compositions, kits, and methods are disclosed for determining one or more target polypeptides in a sample where the target polypeptides have undergone a post-translational modification. The compositions can include a first reagent including a cleavage-inducing moiety and a first binding agent for a binding site that includes a post-translational modification of a target polypeptide.
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: April 10, 2018
    Assignee: Monogram Biosciences, Inc.
    Inventors: Sharat Singh, Hossein Salimi-Moosavi, Syed Hasan Tahir, Gerald J. Wallweber, Hrair Kirakossian, Tracy J. Matray, Vincent S. Hernandez
  • ULTRA BRIGHT DIMERIC OR POLYMERIC DYES
    Publication number: 20180079909
    Abstract: Compounds useful as fluorescent or colored dyes are disclosed. The compounds have the following structure (I): including stereoisomers, salts and tautomers thereof, wherein R1, R2, R3, R4, R5, L1, L2, L3, L4, M, m and n are as defined herein. Methods associated with preparation and use of such compounds are also provided.
    Type: Application
    Filed: May 11, 2016
    Publication date: March 22, 2018
    Inventors: Tracy Matray, Sharat Singh
  • DRUG SELECTION FOR COLORECTAL CANCER THERAPY USING RECEPTOR TYROSINE KINASE PROFILING
    Publication number: 20180080934
    Abstract: The present invention provides methods for selecting a suitable anticancer drug therapy, and for identifying and predicting response, for the treatment of colorectal cancer. The present invention also provides methods for monitoring the status of colorectal cancer and monitoring how a patient with colorectal cancer is responding to anticancer drug therapy. The present invention further provides methods for the rational selection of therapy with one or more anticancer drugs tailored to target signal transduction pathway components with dysregulated expression and/or activation levels in patients with somatic mutations in an oncogene.
    Type: Application
    Filed: June 28, 2017
    Publication date: March 22, 2018
    Applicant: PIERIAN HOLDINGS, INC.
    Inventors: Phillip Kim, Sharat Singh
  • Methods for predicting and improving the survival of colorectal cancer patients
    Patent number: 9903867
    Abstract: The present invention provides assays and methods for predicting the survival of a subject having colorectal cancer (CRC), thereby determining whether the subject will have a good prognosis or poor prognosis. The present invention also provides assays and methods for predicting therapeutic efficacy and/or response to anti-cancer therapeutics in a subject having CRC, thereby selecting a therapeutic regimen to which the subject is likely to be responsive.
    Type: Grant
    Filed: December 30, 2015
    Date of Patent: February 27, 2018
    Assignee: Nestec S.A.
    Inventors: Phillip Kim, Anjali Jain, Sharat Singh
  • SAMPLING SYSTEMS AND RELATED MATERIALS AND METHODS
    Publication number: 20180052084
    Abstract: Sampling systems that include an absorbent material a preservative, such as an analyte preservative, as well as related materials and methods, are disclosed.
    Type: Application
    Filed: August 18, 2017
    Publication date: February 22, 2018
    Inventors: Mitchell Lawrence Jones, Christopher Loren Wahl, Aaron Olafur Laurence Phillippsen, Nicholas David Allan, Mark Sasha Drlik, Ryan Paul McGuinness, Sharat Singh, Bob Magyar
  • SYSTEMS AND METHODS FOR OBTAINING SAMPLES USING INGESTIBLE DEVICES
    Publication number: 20180049725
    Abstract: Ingestible devices configured to obtain samples when present in the GI tract of a subject, as well as related systems and methods, are disclosed. Sampling systems that include an absorbent material a preservative, such as an analyte preservative, as well as related materials and methods, are also disclosed.
    Type: Application
    Filed: August 18, 2017
    Publication date: February 22, 2018
    Inventors: Mitchell Lawrence Jones, Christopher Loren Wahl, Aaron Olafur Laurence Phillippsen, Nicholas David Allan, Mark Sasha Drlik, Ryan Paul McGuinness, Sharat Singh, Bob Magyar
  • Pathway specific assays for predicting irritable bowel syndrome diagnosis
    Patent number: 9891235
    Abstract: The present invention provides antibodies and methods for preparing antibodies to metabolites in the serotonin, tryptophan, kynurenine pathways. The prepared antibodies have low cross-reactivity to related metabolites, and are useful reagents for specific and sensitive immunoassays The present invention also provides stable derivatives of various metabolites and short chain fatty acids. The derivative can be conjugated to a biomolecule such as a carrier protein and combined with an adjuvant to stimulate an immune response. The derivatives can also be conjugated to other biomolecules.
    Type: Grant
    Filed: November 11, 2015
    Date of Patent: February 13, 2018
    Assignee: Nestec S.A.
    Inventors: Fabiyola Selvaraj, Fred Princen, Sharat Singh
  • Ultra bright dimeric or polymeric dyes with spacing linker groups
    Patent number: 9851359
    Abstract: Compounds useful as fluorescent or colored dyes are disclosed. The compounds have the following structure (I): or a stereoisomer, tautomer or salt thereof, wherein R1, R2, R3, R4, R5, L1, L2, L3, L4, M, m and n are as defined herein. Methods associated with preparation and use of such compounds are also provided.
    Type: Grant
    Filed: April 6, 2017
    Date of Patent: December 26, 2017
    Assignees: SONY CORPORATION OF AMERICA, SONY CORPORATION
    Inventors: Tracy Matray, Sharat Singh
  • Biomarker panel for assessment of mucosal healing
    Patent number: 9835632
    Abstract: The present invention provides methods for predicting the likelihood of mucosal healing in an individual with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis (UC). In addition, the present invention provides methods for monitoring the progression of mucosal healing in an individual with a disease such as IBD. Information on mucosal healing status derived from the use of the present invention can also aid in optimizing therapy and/or monitoring the therapeutic efficiency of an anti-TNF? inhibitor drug.
    Type: Grant
    Filed: July 18, 2016
    Date of Patent: December 5, 2017
    Assignee: Nestec S.A.
    Inventors: Sharat Singh, Severine Vermeire