Abstract: A system includes Adapter, Clip, Member, Wire and Mechanism. Adapter includes a proximal portion mounted over a distal end of an insertion device and a distal portion extending distally from the proximal portion. Clip includes Jaws to move between insertion configuration, in which Jaws extend about Adapter and are separated to receive tissue, and initial configuration, in which Clip is moved distally off of Adapter so that Jaws grip tissue. Member is releasably coupled to Clip and movably connected to Adapter. Member extends from a proximal portion to remain, in an operative configuration, outside body to a distal portion to be coupled to the distal end. Wire is received within Member and extends to a distal end releasably coupled to Clip via Link when predetermined force is applied. Mechanism selectively locks the distal portion of Member against proximal movement relative to Adapter during release of Link.

Abstract: A clipping system includes an adapter configured to be mounted over an insertion device and a clip including first and second jaws movable between an insertion configuration and an initial deployed configuration. A first extending member is releasably coupled to the clip and movably connected to the adapter to permit a movement of the clip relative to the adapter from the insertion configuration to the initial deployed configuration. The first extending member is configured to permit withdrawal of the adapter away from the clip to place the system in a review configuration to enhance a visual observation of the clip. The first extending member is operable to retract the clip over the adapter so that the clip is forced open, freeing the clip from tissue on which it has been clipped. The first extending member is configured to release the clip therefrom in a final deployed configuration.

Abstract: In one example, a medical device may include a handle including a proximal portion and a distal portion, and the proximal portion may pivot relative to the distal portion. The medical device may also include an insertion portion coupled to the distal portion of the handle and configured to be positioned within a body lumen; and an articulation wire extending from the handle through the insertion portion. Pivoting of the proximal portion of the handle relative to the distal portion of the handle may move the articulation wire relative to the insertion portion to bend a distal portion of the insertion portion.

Abstract: Systems for use with an endoscope are disclosed. An example system may include a sleeve configured to be coupled to an outer surface of an endoscope. A housing may be coupled to the sleeve. The housing may have a proximal end region, a distal end region, and a fluid chamber defined therein. A plurality of openings may be formed in the distal end region. An actuator may be coupled to the proximal end region of the housing and extend proximally therefrom. A distal ring member may be disposed within the housing. The distal ring member may be axially fixed relative to the sleeve and relative to the housing. The housing is configured to shift relative to the endoscope between a first position and a second position.

Abstract: A clipping system includes an adapter mounted on an insertion device and a clip including first and second jaws connected via hinges so that the first and second jaws are movable between an insertion configuration and an initial deployed configuration. A deployment member is configured to move the clip distally over and off of the adapter so that, as the clip leaves the adapter, the clip moves from the insertion configuration to the initial deployed configuration. An extending member is releasably coupled to the clip and movably connected to the adapter, and is configured to permit the withdrawal of the adapter away from the clip while the extending member remains coupled to the clip to place the system in a review configuration. The extending member is operable to retract the clip over the adapter, freeing the clip from tissue on which it had been clipped.

Abstract: A steerable medical device includes a first wire and a second wire. The first wire includes a first portion having a first width and a second portion having a second width. The second width is smaller than the first width. A distal end of the first wire is fixed relative to a distal end the second wire. A proximal end of one or more of the first wire or the second wire is moveable distally or proximally with respect to the other of the first wire or the second wire in order to bend a distal portion of the steerable medical device.

Abstract: Systems and methods for a medical device are disclosed. For example, the medical device may include a frame configured to transition from a contracted configuration to an expanded configuration, and a cover disposed on the frame. The cover may include a plurality of projections extending radially outward from an outer surface of the cover.

Abstract: A device includes a capture assembly, a hollow member, a tube, and a control member. The assembly includes a capture sleeve received on a distal end of an insertion device and a flange mounted on the insertion device proximal of the sleeve. The hollow member, the tube, and the control member each have a proximal end accessible by the user. The tube pushes the sleeve distally off the insertion device when the tube is advanced distally through the hollow member. The control member includes a distal end forming a loop coupled around a circumference of a distal opening of the sleeve. The loop moves between a constricted configuration in which at least a portion of the loop is drawn proximally into the tube and an 10 open configuration in which the loop is extended distally from the tube to open the loop and the distal opening of the sleeve.

Abstract: A cytology brush includes a shaft including a fluid lumen configured for passage of a fluid; a brush body including: a fixed element; and a moveable element with a radial outward surface and a plurality of bristles, wherein the bristles protrude externally from the radial outward surface. The moveable element is configured to receive the fluid through the fluid lumen to expand from an unexpanded configuration to an expanded configuration and in the unexpanded configuration of the moveable element, the bristles are in a retracted configuration and in the expanded configuration the bristles are in a deployed configuration.

Abstract: A clipping system includes an adapter configured to be mounted over an insertion device and a clip including first and second jaws movable between an insertion configuration and an initial deployed configuration. A first extending member is releasably coupled to the clip and movably connected to the adapter to permit a movement of the clip relative to the adapter from the insertion configuration to the initial deployed configuration. The first extending member is configured to permit withdrawal of the adapter away from the clip to place the system in a review configuration to enhance a visual observation of the clip. The first extending member is operable to retract the clip over the adapter so that the clip is forced open, freeing the clip from tissue on which it has been clipped. The first extending member is configured to release the clip therefrom in a final deployed configuration.

Abstract: In one example, a medical device may include a handle including a proximal portion and a distal portion, and the proximal portion may pivot relative to the distal portion. The medical device may also include an insertion portion coupled to the distal portion of the handle and configured to be positioned within a body lumen; and an articulation wire extending from the handle through the insertion portion. Pivoting of the proximal portion of the handle relative to the distal portion of the handle may move the articulation wire relative to the insertion portion to bend a distal portion of the insertion portion.

Abstract: A system includes a cap having first and second cap members, a clip, and first and second coupling members. The clip includes a first part rotatably coupled to a second part and first members coupled to the first part and corresponding second members coupled to the second part. Each of the first members is coupled to a corresponding one of the second members to form an iris mechanism operating to alter a size of a central opening of the clip when the parts are rotated relative to one another between open/closed configurations. The first coupling member is coupled between the first cap member and the first part, and the second coupling member is coupled between the second cap member and the second part so that, upon rotation of the first cap member relative to the second cap member, the first part is rotated relative to the second part.

Abstract: A clipping system includes an adapter mounted on an insertion device and a clip including first and second jaws connected via hinges so that the first and second jaws are movable between an insertion configuration and an initial deployed configuration. A deployment member is configured to move the clip distally over and off of the adapter so that, as the clip leaves the adapter, the clip moves from the insertion configuration to the initial deployed configuration. An extending member is releasably coupled to the clip and movably connected to the adapter, and is configured to permit the withdrawal of the adapter away from the clip while the extending member remains coupled to the clip to place the system in a review configuration. The extending member is operable to retract the clip over the adapter, freeing the clip from tissue on which it had been clipped.

Abstract: A device includes a cap, a patch deployment mechanism, and a therapeutic patch. The cap includes a wall defining a chamber with an open distal end. The mechanism is slidably received within the chamber in an insertion configuration and includes proximal and distal members coupled by bowing members. The bowing members expand radially outward relative to the insertion configuration when longitudinally compressed via movement of the distal member toward the proximal member. The patch is wrapped around the mechanism and is forced radially outward into contact with and adhere to a target portion of tissue when the mechanism is longitudinally compressed and the bowing members are radially expanded. The mechanism is to radially retracted after the patch has been adhered to the portion, from a deployed configuration to the insertion configuration to separate the patch from the mechanism leaving the patch in a desired position adhered to the portion.

Abstract: A medical device may include a handle and an end cap. The handle may include a first movable body and a stationary body. The end cap may include an outer portion, an inner portion disposed within the outer portion, and at least one biasing member. The outer portion may define a receptacle configured to contain a material. The inner portion may be proximal to the receptacle, within the outer portion, and coupled to the first movable body by at least one control element. The biasing member(s) may be disposed between a proximal face of the inner portion and a distal face of a proximal wall of the outer portion. Accordingly, movement of the first movable body relative to the stationary body moves the inner portion relative to the outer portion. Movement of the inner portion may be configured to deliver the material.

Abstract: A medical device may comprise a handle having a fluid source, a conduit coupled to the handle, and a distal portion coupled to a distal end of the conduit. The distal portion may comprise an outer portion defining a lumen and an inner portion. The inner portion may be disposed within the lumen if the outer portion. The inner portion may define a cavity having a distal opening. The cavity may be configured to contain a material. In a first configuration of the distal portion, the material is disposed within the inner portion. Delivery of a fluid from the fluid source into the lumen of the outer portion transitions the distal portion from the first configuration to a second configuration and causes the inner portion to move distally relative to the outer portion and deliver at least a portion of the material.

Abstract: A device includes a flexible sheath, a member, an expansion device, and a therapeutic patch. The sheath has a length selected to extend from a distal end which, when the device is in operative configuration, is adjacent to the target site, to a proximal end. The member extends through the sheath from a proximal end to a distal end. The expansion device is coupled to and extends distally from a distal end of the member. The patch is wrapped around the expansion device and forced radially outward into contact with and adhere to a first target portion of tissue when the expansion device is moved to deployed configuration. The expansion device is movable, after the patch has been adhered to the portion as desired, from deployed configuration to insertion configuration to separate the patch from the expansion device leaving the patch in a desired position adhered to the portion.

Abstract: A medical device may comprise: a handle including an actuator, an end container configured to be coupled to a distal end of another medical device, the end container including a cavity including a movable portion, at least one channel, and a distal opening; a control element coupling the actuator to the movable portion of the end container. A proximal movement of the actuator may move the movable portion of the end container proximally within the cavity of the end container. The cavity may be configured to hold a fluid, and the proximal movement of the movable portion is configured to apply a compressive force to the fluid so that the fluid is expelled distally through the distal opening.

Abstract: A medical device that includes a handle, a shaft extending distally from the handle, an end effector extending distally from the shaft, a first actuator movably coupled to the handle, and a second actuator movably coupled to the handle. The first actuator is configured to (1) articulate the shaft in response to translating the first actuator in a first direction relative to the handle and the second actuator, and (2) actuate the end effector in response to translating the first actuator in a second direction relative to the handle and the second actuator. The second actuator is configured to (1) articulate the shaft in response to translating the second actuator in the first direction relative to the handle and the first actuator, and (2) actuate the end effector in response to translating the second actuator in the second direction relative to the handle and the first actuator.

Abstract: A delivery device comprises a tube having a proximal end, a distal end, and a lumen extending from the proximal to the distal end. The proximal end is mountable to a distal tip of a medical device via the lumen. The tube includes an inner wall defining the lumen, an outer wall coupled to the inner wall at the proximal and distal ends, a cavity formed from the coupled inner and outer walls and configured to hold a deliverable substance, and a plurality of openings connected to the cavity and positioned on a distal-facing surface of the distal end. At least a portion of the inner wall or the outer wall is a flexible wall that transitions between a first and a second configuration to cause delivery of the deliverable substance from the cavity to a treatment site through the openings when a force is applied to the flexible wall.