Patents by Inventor Sharief Barends

Sharief Barends has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230340476
    Abstract: The present invention describes mRNA usage improving and/or translation-enhancing nucleic acid sequences, nucleic acid constructs comprising such sequences, and host cells comprising such nucleic acid constructs. The invention further pertains to a method for expressing a protein of interest in a cell or organism using such nucleic acid sequences, as well as their uses for increasing integration of such nucleic acid construct into a genome, for enhancing mRNA usage and/or translation of a recombinantly expressed polypeptide, and for increasing the number of transformants upon transformation of a cell with such nucleic acid construct.
    Type: Application
    Filed: April 19, 2023
    Publication date: October 26, 2023
    Inventors: Raymond Michael Dimphena Verhaert, Pieter Victor Schut, Sharief Barends, Maurice Wilhelmus van der Heijden
  • Patent number: 11667921
    Abstract: The present invention describes mRNA usage improving and/or translation-enhancing nucleic acid sequences, nucleic acid constructs comprising such sequences, and host cells comprising such nucleic acid constructs. The invention further pertains to a method for expressing a protein of interest in a cell or organism using such nucleic acid sequences, as well as their uses for increasing intergration of such nucleic acid construct into a genome, for enhancing mRNA usage and/or translation of a recombinantly expressed polypeptide, and for increasing the number of transformants upon transformation of a cell with such nucleic acid construct.
    Type: Grant
    Filed: December 28, 2020
    Date of Patent: June 6, 2023
    Assignee: Proteonic Biotechnology IP B.V.
    Inventors: Raymond Michael Dimphena Verhaert, Pieter Victor Schut, Sharief Barends, Maurice Wilhelmus van der Heijden
  • Publication number: 20230055224
    Abstract: Disclosed are compositions and methods relating to an improved hybrid lipase enzyme for reducing foaming in, for example, a carbohydrate fermentation process.
    Type: Application
    Filed: March 13, 2020
    Publication date: February 23, 2023
    Inventors: Sharief BARENDS, Svetlana Laura IANCU, Scott D. POWER, Marco VAN BRUSSEL-ZWIJNEN
  • Publication number: 20220389474
    Abstract: The present disclosure is generally related to the fields of biology, molecular biology, genetics, microbial host cells, industrial enzyme production, and the like. More particularly, certain embodiments of the disclosure are related to microbial host cells for the production of heterologous proteins, which microbial host cells are well-suited for growth in submerged cultures for the large-scale production of heterologous cyanuric acid hydrolases and biuret hydrolases.
    Type: Application
    Filed: October 14, 2020
    Publication date: December 8, 2022
    Inventors: Sharief Barends, Cristina Bongiorni, Feng Guo, Lori Ann Maggio-Hall, Lawrence Philip Wackett, Gregory M. Whited
  • Publication number: 20210115446
    Abstract: The present invention describes mRNA usage improving and/or translation-enhancing nucleic acid sequences, nucleic acid constructs comprising such sequences, and host cells comprising such nucleic acid constructs. The invention further pertains to a method for expressing a protein of interest in a cell or organism using such nucleic acid sequences, as well as their uses for increasing intergration of such nucleic acid construct into a genome, for enhancing mRNA usage and/or translation of a recombinantly expressed polypeptide, and for increasing the number of transformants upon transformation of a cell with such nucleic acid construct.
    Type: Application
    Filed: December 28, 2020
    Publication date: April 22, 2021
    Inventors: Raymond Michael Dimphena Verhaert, Pieter Victor Schut, Sharief Barends, Maurice Wilhelmus van der Heijden
  • Patent number: 10876113
    Abstract: The present invention describes mRNA usage improving and/or translation-enhancing nucleic acid sequences, nucleic acid constructs comprising such sequences, and host cells comprising such nucleic acid constructs. The invention further pertains to a method for expressing a protein of interest in a cell or organismusing such nucleic acid sequences, as well as their uses for increasing integration of such nucleic acid construct into a genome, for enhancing mRNA usage and/or translation of a recombinantly expressed polypeptide, and for increasing the number of transformants upon transformation of a cell with such nucleic acid construct.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: December 29, 2020
    Inventors: Raymond Michael Dimphena Verhaert, Pieter Victor Schut, Sharief Barends, Maurice Wilhelmus van der Heijden
  • Patent number: 10550375
    Abstract: The present invention relates to an isolated polypeptide having xylanase activity, selected from the group consisting of: a) a polypeptide comprising an amino acid sequence having at least 87% identity with SEQ ID NO: 1; b) a polypeptide encoded by a polynucleotide having at least 87% identity with SEQ ID NO:2; or c) a fragment of a polypeptide of a) or b) which fragment has xylanase activity.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: February 4, 2020
    Assignee: DuPont Nutrition Biosciences ApS
    Inventors: Rikke Hoeegh Lorentsen, Susan Arent Lund, Svend Haaning, Igor Nikolaev, Sharief Barends, Jan Hendrick A Van Tuijl, Bart Koops
  • Publication number: 20180044677
    Abstract: The present invention describes mRNA usage improving and/or translation-enhancing nucleic acid sequences, nucleic acid constructs comprising such sequences, and host cells comprising such nucleic acid constructs. The invention further pertains to a method for expressing a protein of interest in a cell or organismusing such nucleic acid sequences, as well as their uses for increasing integration of such nucleic acid construct into a genome, for enhancing mRNA usage and/or translation of a recombinantly expressed polypeptide, and for increasing the number of transformants upon transformation of a cell with such nucleic acid construct.
    Type: Application
    Filed: September 29, 2017
    Publication date: February 15, 2018
    Inventors: Raymond Michael Dimphena Verhaert, Pieter Victor Schut, Sharief Barends, Maurice Wilhelmus van der Heijden
  • Publication number: 20170260559
    Abstract: Provided are fungal host strains and recombinant DNA constructs for creation and use thereof, wherein the fungal host strains are particularly stable and useful for expressing proteins, enzymes, variants and other substances of interest in a reliable or less variable fashion.
    Type: Application
    Filed: December 1, 2015
    Publication date: September 14, 2017
    Applicant: DANISCO US INC.
    Inventors: Mark ARENTSHORST, Sharief BARENDS, Paulien KRUITHOF, Igor NIKOLAEV, Jean Paul OUEDRAOGO, Arthur F.J. RAM
  • Publication number: 20170009220
    Abstract: The present invention relates to an isolated polypeptide having xylanase activity, selected from the group consisting of: a) a polypeptide comprising an amino acid sequence having at least 87% identity with SEQ ID NO: 1; b) a polypeptide encoded by a polynucleotide having at least 87% identity with SEQ ID NO:2; or c) a fragment of a polypeptide of a) or b) which fragment has xylanase activity.
    Type: Application
    Filed: January 30, 2015
    Publication date: January 12, 2017
    Applicant: DuPont Nutrition Biosciences ApS
    Inventors: Rikke Hoeegh Lorentsen, Susan Arent Lund, Svend Haaning, Igor Nikolaev, Sharief Barends, Jan Hendrick A Van Tuijl, Bert Koops
  • Publication number: 20140342432
    Abstract: Described are compositions and methods relating to the expression of genes of interest in fungal cells using insulator DNA sequences.
    Type: Application
    Filed: December 12, 2012
    Publication date: November 20, 2014
    Applicant: Danisco US Inc.
    Inventors: Sharief Barends, Michael Ward
  • Publication number: 20130239236
    Abstract: The present invention describes mRNA usage improving and/or translation-enhancing nucleic acid sequences, nucleic acid constructs comprising such sequences, and host cells comprising such nucleic acid constructs. The invention further pertains to a method for expressing a protein of interest in a cell or organism using such nucleic acid sequences, as well as their uses for increasing integration of such nucleic acid construct into a genome, for enhancing mRNA usage and/or translation of a recombinantly expressed polypeptide, and for increasing the number of transformants upon transformation of a cell with such nucleic acid construct.
    Type: Application
    Filed: September 30, 2011
    Publication date: September 12, 2013
    Applicant: R1 B3 Holdings B.V.
    Inventors: Raymond Michael Dimphena Verhaert, Pieter Victor Schut, Sharief Barends, Maurice Wilhelmus van der Heijden