Patents by Inventor Sharmila A. BAPAT

Sharmila A. BAPAT has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tumor deconstruction platform for the analysis of intra-tumor heterogeneity
    Patent number: 10429393
    Abstract: The present invention provides a method for concurrent resolution of the cancer stem cell (CSC) derived hierarchy, genetic instability, differentially cycling cells and host cells recruited for performing tumor growth supporting functions; and (ii) quantification, monitoring and analysis of these populations. The first level of analysis can be carried out using either CSC- and progenitor-specific markers or a marker-free approach based on label-chase to resolve the tumor regenerative hierarchy. The next level involves combinatorial quantification of differential DNA-RNA contents to identify recruited host and tumor cell variants resulted from genetic instability and differential cycling within the tumor.
    Type: Grant
    Filed: January 17, 2015
    Date of Patent: October 1, 2019
    Assignee: NATIONAL CENTRE FOR CELL SCIENCE
    Inventors: Sharmila A. Bapat, Rutika R. Naik
  • A TUMOR DECONSTRUCTION PLATFORM FOR THE ANALYSIS OF INTRA-TUMOR HETEROGENEITY
    Publication number: 20170067901
    Abstract: The present invention provides a method for concurrent resolution of the cancer stem cell (CSC) derived hierarchy, genetic instability, differentially cycling cells and host cells recruited for performing tumor growth supporting functions; and (ii) quantification, monitoring and analysis of these populations. The first level of analysis can be carried out using either CSC- and progenitor-specific markers or a marker-free approach based on label-chase to resolve the tumor regenerative hierarchy. The next level involves combinatorial quantification of differential DNA-RNA contents to identify recruited host and tumor cell variants resulted from genetic instability and differential cycling within the tumor.
    Type: Application
    Filed: January 17, 2015
    Publication date: March 9, 2017
    Applicant: National Centre for Cell Science
    Inventors: Sharmila A. BAPAT, Rutika R. NAIK