Patents by Inventor Sharon A. Jenkins

Sharon A. Jenkins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunoadjuvants
    Patent number: 6261573
    Abstract: The present invention provides immunogenic compositions and methods for inducing enhanced immune responses using an antigen and a combination of water soluble polymer and an amphiphilic compound.
    Type: Grant
    Filed: October 25, 1999
    Date of Patent: July 17, 2001
    Assignee: Avant Immunotherapeutics, Inc.
    Inventors: Jean R. Loebelenz, Bryan E. Roberts, Alexander K. Andrainov, Sharon A. Jenkins
  • Polyphosphazene microspheres
    Patent number: 6207171
    Abstract: A soluble polyphosphazene polyelectrolyte immunoadjuvant is disclosed. In one embodiment, the polymeric adjuvant is poly[di(carboxylatrophenoxy)phosphazene] which is in the form of a microsphere and which is adsorbed with antigen after formation of the microsphere. The immunoadjuvant can be administered intranasally.
    Type: Grant
    Filed: March 25, 1999
    Date of Patent: March 27, 2001
    Assignee: Avant Immunotherapeutics, Inc.
    Inventors: Lendon G. Payne, Angela L. Woods, Sharon A. Jenkins
  • Composition to protect a mammal against Bartonella henselae infection
    Patent number: 5958414
    Abstract: The present invention relates to a therapeutic composition to protect a mammal from B. henselae infection that includes an isolated B. henselae antigen and an adjuvant comprising a phosphazene polymer. Also included is a method to use such a therapeutic composition to protect a mammal from B. henselae infection. One embodiment is a method to protect a human from cat scratch disease by administering such a therapeutic composition to a domestic cat in contact with the human. The present invention also includes a method to produce such a therapeutic composition.
    Type: Grant
    Filed: September 3, 1997
    Date of Patent: September 28, 1999
    Assignees: Heska Corporation, Avant Immunotherapeutics, Inc., The United States of America as represented by the Department of Health and Human Services
    Inventors: Russell L. Regnery, Jane A. Rooney, Sharon A. Jenkins
  • HIV-1 prophylactic composition and method
    Patent number: 5891444
    Abstract: A composition and method for inducing a protective immune response to HIV-1 in an individual, of (a) a replication incompetent HIV-1, HIV-1 pseudovirus, HIV-1 VLP or oligomeric gp120; and (b) a water soluble polyphosphazene polyelectrolyte, wherein (a) and (b) are present in an amount effective to induce a protective immune response against HIV-1.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 6, 1999
    Assignee: Virus Research Institute, Inc.
    Inventors: Sharon Jenkins, Yichen Lu, Lendon Payne, Bryan Roberts
  • Hydrogel microencapsulated vaccines
    Patent number: 5529777
    Abstract: Water soluble polymers or polymeric hydrogels are used to encapsulate antigen to form vaccines. The antigen is mixed with a polymer solution, microparticles are formed of the polymer and antigen, and, optionally, the polymer is crosslinked to form a stable microparticle. Preferred polymers are alginate and polyphosphazenes, and mixtures thereof. Microparticles can be adminstered parenterally or mucosally. For oral delivery, the microparticles are preferably fifteen microns or less in diameter, and adhere to the mucosal lining of the gastrointestinal tract, increasing uptake by the reticuloendothelium.
    Type: Grant
    Filed: November 4, 1993
    Date of Patent: June 25, 1996
    Assignee: Virus Research Institute
    Inventors: Alexander K. Andrianov, Sharon A. Jenkins, Lendon G. Payne, Bryan E. Roberts
  • Phosphazene polyelectrolytes as immunoadjuvants
    Patent number: 5494673
    Abstract: An immunoadjuvant soluble polyphosphazene polyelectrolyte is disclosed. In one embodiment, the polymeric adjuvant is an poly(organophosphazene) with (i) ionized or ionizable pendant groups that contain, for example, carboxylic acid, sulfonic acid, or hydroxyl moieties, and (ii) pendant groups that are susceptible to hydrolysis under the conditions of use, to impart biodegradability to the polymer.
    Type: Grant
    Filed: July 11, 1994
    Date of Patent: February 27, 1996
    Assignee: Virus Research Institute
    Inventors: Alexander K. Andrianov, Sharon A. Jenkins, Lendon G. Payne, Bryan E. Roberts