Abstract: The present disclosure provides compounds, compositions, and methods, wherein the compounds include a modified cholic acid or a cholic acid component and at least a second component in which the second component is conjugated to the modified cholic acid or cholic acid having the following structure: In certain instances, the conjugate compound provides reduced cytotoxicity, greater efficacy, and a more robust MOA (e.g., the entry into a cell is more facile or multiple modes of action occur) compared to the non-conjugated component alone. In certain instances, the second component such as biotin is covalently linked to the modified cholic acid or cholic acid.