Abstract: Devices and methods for managing the contaminants to which an individual's face is exposed when sleeping or resting on a pillow and/or pillowcase. The device may comprise a disposable pillow cover configured to receive a pillow and/or pillowcase therein such that an individual need not rest his or her head directly against the pillow or pillowcase. This may be beneficial to travelers, persons suffering from skin disorders or patients who are recovering from medical or cosmetic dermatologic procedures and thus have compromised skin. At least one embodiment of the methods disclosed herein comprises the steps of providing a disposable pillow cover, wrapping at least a substantial portion of a pillow and/or pillowcase within the disposable pillow cover to provide a barrier between the individual's skin and the pillow and/or pillowcase, and using the disposable pillow cover to prevent contaminants from coming into contact with the individual's skin.