Patents by Inventor Sharon Engel

Sharon Engel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FUSED DIHYDRO-4H-PYRAZOLO[5,1-C][1,4]OXAZINYL COMPOUNDS AND ANALOGS FOR TREATING CNS DISORDERS
    Publication number: 20210300942
    Abstract: Disclosed are compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein Ring B, A1, A2, R6, w and n1 are defined and described herein; compositions thereof; and methods of use thereof. These compounds are useful for treating a variety of neurological and psychiatric disorders, such as those described herein.
    Type: Application
    Filed: February 19, 2021
    Publication date: September 30, 2021
    Applicants: Sunovion Pharmaceuticals Inc., PGI Drug Discovery LLC
    Inventors: Milan CHYTIL, Sharon ENGEL, Taleen G. HANANIA, Vadim ALEXANDROV, Emer LEAHY
  • FUSED DIHYDRO-4H-PYRAZOLO[5,1-C][1,4]OXAZINYL COMPOUNDS AND ANALOGS FOR TREATING CNS DISORDERS
    Publication number: 20200024286
    Abstract: Disclosed are compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein Ring B, A1, A2, R6, w and n1 are defined and described herein; compositions thereof; and methods of use thereof. These compounds are useful for treating a variety of neurological and psychiatric disorders, such as those described herein.
    Type: Application
    Filed: May 6, 2019
    Publication date: January 23, 2020
    Applicants: Sunovion Pharmaceuticals Inc., PGI Drug Discovery LLC
    Inventors: Milan CHYTIL, Sharon ENGEL, Taleen G. HANANIA, Vadim ALEXANDROV, Emer LEAHY
  • FUSED DIHYDRO-4H-PYRAZOLO[5,1-C][1,4]OXAZINYL COMPOUNDS AND ANALOGS FOR TREATING CNS DISORDERS
    Publication number: 20180057506
    Abstract: Disclosed are compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein Ring B, A1, A2, R6, w and n1 are defined and described herein; compositions thereof; and methods of use thereof. These compounds are useful for treating a variety of neurological and psychiatric disorders, such as those described herein.
    Type: Application
    Filed: August 2, 2017
    Publication date: March 1, 2018
    Applicants: Sunovion Pharmaceuticals Inc., PGI Drug Discovery LLC
    Inventors: Milan CHYTIL, Sharon Engel, Taleen G. HANANIA, Vadim ALEXANDROV, Emer LEAHY
  • Fused dihydro-4H-pyrazolo[5,1-C][1,4]oxazinyl compounds and analogs for treating CNS disorders
    Patent number: 9758529
    Abstract: Disclosed are compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein Ring B, A1, A2, R6, w and n1 are defined and described herein; compositions thereof; and methods of use thereof. These compounds are useful for treating a variety of neurological and psychiatric disorders, such as those described herein.
    Type: Grant
    Filed: February 11, 2016
    Date of Patent: September 12, 2017
    Assignees: Sunovion Pharmaceuticals Inc., PGI Drug Discovery LLC
    Inventors: Milan Chytil, Sharon Engel, Taleen G. Hanania, Vadim Alexandrov, Emer Leahy
  • FUSED DIHYDRO-4H-PYRAZOLO[5,1-C][1,4]OXAZINYL COMPOUNDS AND ANALOGS FOR TREATING CNS DISORDERS
    Publication number: 20160264597
    Abstract: Disclosed are compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein Ring B, A1, A2, R6, w and n1 are defined and described herein; compositions thereof; and methods of use thereof. These compounds are useful for treating a variety of neurological and psychiatric disorders, such as those described herein.
    Type: Application
    Filed: February 11, 2016
    Publication date: September 15, 2016
    Inventors: Milan Chytil, Sharon Engel, Taleen G. Hanania, Vadim Alexandrov, Emer Leahy
  • Cycloalkylamines as monoamine reuptake inhibitors
    Publication number: 20070203111
    Abstract: The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.
    Type: Application
    Filed: January 5, 2007
    Publication date: August 30, 2007
    Applicant: SEPRACOR INC.
    Inventors: Liming Shao, Fengjiang Wang, Scott Malcolm, Michael Hewitt, Larry Bush, Jianguo Ma, Mark Varney, Una Campbell, Sharon Engel, Larry Hardy, Patrick Koch, John Campbell
  • Tetralone-based monoamine reuptake inhibitors
    Publication number: 20070197588
    Abstract: The invention relates to novel tetralone based amines and their use in the treatment of central nervous system (CNS) disorders, such as depression, attention deficit hyperactivity disorder (ADHD) and Parkinson's disease. The invention further relates to pharmaceutical compositions containing the compounds and compositions of the invention as well as methods of inhibiting reuptake of one or more monoamine, such as such as dopamine and norepinephrine, from the synaptic cleft, and methods of modulating one or more monoamine transporter.
    Type: Application
    Filed: December 21, 2006
    Publication date: August 23, 2007
    Applicant: SEPRACOR INC.
    Inventors: Liming Shao, Fengjiang Wang, Scott Malcolm, Michael Hewitt, Larry Bush, Mark Varney, Una Campbell, Sharon Engel, Larry Hardy, Patrick Koch, Jianguo Ma
  • Alternative splice variants
    Publication number: 20040258681
    Abstract: The invention concerns novel nucleic acid sequences and amino acid sequences obtained by alternative splicing, expression vectors, host cell and pharmaceutical compositions comprising said sequences.
    Type: Application
    Filed: February 20, 2004
    Publication date: December 23, 2004
    Applicant: Compugen Ltd. Corporation
    Inventors: Kinneret Savitzky, Liat Mintz, Sharon Engel, Jeanne Bernstein
  • VEGF nucleic acid and amino acid sequences
    Patent number: 6783954
    Abstract: The invention concerns novel nucleic acid sequences and amino acid sequences of a novel variant of vascular endothelial growth factor (VEGF). The invention further concerns expression vectors and host cells containing said sequences as well as pharmaceutical compositions and detection methods using said sequences.
    Type: Grant
    Filed: June 20, 2001
    Date of Patent: August 31, 2004
    Assignee: Compugen Ltd.
    Inventors: Liat Mintz, Kinneret Savitzky, Sharon Engel
  • Alternative splice variants of CD40
    Patent number: 6720182
    Abstract: The invention concerns novel nucleic acid sequences and amino acid sequences obtained by alternative splicing, expression vectors, host cell and pharmaceutical compositions comprising said sequences.
    Type: Grant
    Filed: May 10, 2000
    Date of Patent: April 13, 2004
    Assignee: Compugen Ltd. Corporation
    Inventors: Kinneret Savitzky, Liat Mintz, Sharon Engel, Jeanne Bernstein
  • Novel nucleic acid and amino acid sequences
    Publication number: 20030125295
    Abstract: The invention concerns novel nucleic acid sequences and amino acid sequences of a novel variant of vascular endothelial growth factor (VEGF). The invention further concerns expression vectors and host cells containing said sequences as well as pharmaceutical compositions and detection methods using said sequences.
    Type: Application
    Filed: November 19, 2002
    Publication date: July 3, 2003
    Applicant: Compugen Ltd.
    Inventors: Liat Mintz, Kinneret Savitzky, Sharon Engel
  • Variant of vascular endothelial growth factor
    Patent number: 6506884
    Abstract: The invention concerns novel nucleic acid sequences and amino acid sequences of a novel variant of vascular endothelial growth factor (VEGF). The invention further concerns expression vectors and host cells containing said sequences as well as pharmaceutical compositions and detection methods using said sequences.
    Type: Grant
    Filed: March 6, 2000
    Date of Patent: January 14, 2003
    Assignee: Compugen Ltd.
    Inventors: Liat Mintz, Kinneret Savitzky, Sharon Engel
  • Novel nucleic acid and amino acid sequences
    Publication number: 20020103149
    Abstract: The invention concerns novel nucleic acid sequences and amino acid sequences of a novel variant of vascular endothelial growth factor (VEGF). The invention further concerns expression vectors and host cells containing said sequences as well as pharmaceutical compositions and detection methods using said sequences.
    Type: Application
    Filed: June 20, 2001
    Publication date: August 1, 2002
    Inventors: Liat Mintz, Kinneret Savitzky, Sharon Engel