Patents by Inventor Sharon M. Wahl

Sharon M. Wahl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for the inhibition of HIV-1 replication
    Patent number: 8288439
    Abstract: This invention relates to methods and compositions for the attenuation of HIV-1 replication in human cells, and especially in human macrophages. The invention particularly concerns the use of inhibitors of P21 (CDKNIA) expression to attenuate such replication. The invention particularly concerns the use of antisense P21 oligonucleotides, siRNA and/or 2-cyano-3,12-dioxooleana-1,9-dien28-oic (CDDO) to attenuate such replication.
    Type: Grant
    Filed: November 3, 2004
    Date of Patent: October 16, 2012
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Sharon M. Wahl, Nancy Vazquez-Maldonado, Teresa Greenwell-Wild
  • Methods and Compositions For the Inhibition of Hiv-1 Replication
    Publication number: 20080242602
    Abstract: This invention relates to methods and compositions for the attenuation of HIV-1 replication in human cells, and especially in human macrophages. The invention particularly concerns the use of inhibitors of P21 (CDKN1A) expression to attenuate such replication. The invention particularly concerns the use of antisense P21 oligonucleotides, siRNA and/or 2-cyano-3,12-dioxooleana-1,9-dien28-oic (CDDO) to attenuate such replication.
    Type: Application
    Filed: November 3, 2004
    Publication date: October 2, 2008
    Applicant: Government of the US, as represented by the Secret Deepartment of Health andHuman Services
    Inventors: Sharon M. Wahl, Nancy Vazquez-Maldonado, Teresa Greenwell-Wild
  • Inhibition of retrovirus infection
    Patent number: 6869925
    Abstract: Methods and pharmaceutical compositions are provided to prevent retroviral infections of host cells. More particularly, the invention relates to prevention of HIV infection of human cells by serine leukocyte protease inhibitor (SLPI).
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 22, 2005
    Assignees: Amgen Inc., The United States of America as represented by the Department of Health and Human Services
    Inventors: Stephen Eisenberg, Sharon M. Wahl, Robert C. Thompson
  • Inhibition of retrovirus infection
    Patent number: 6017880
    Abstract: Methods and pharmaceutical compositions are provided to prevent retroviral infections of host cells. More particularly, the invention relates to prevention of HIV infection of human cells by serine leukocyte protease inhibitor (SLPI).
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 25, 2000
    Assignees: Amgen Inc., The United States of America as represented by the Department of Health and Human Services
    Inventors: Stephen Eisenberg, Sharon M. Wahl, Robert C. Thompson, David J. Dripps
  • Method for treating ischemia using polypeptides with fibronectin activity
    Patent number: 5840691
    Abstract: Methods for treating ischemia using polypeptides with fibronectin related activity are provided. The methods involve administering an effective amount of one or more polypeptides which include an amino acid sequence corresponding substantially to isolated an amino acid sequence from the 33 kD carboxy terminal heparin-binding region located on the A chain of fibronectin or an RGD-containing amino acid sequence within the 11.5 kD RGDS-mediated cell adhesion region located on all isoforms of fibronectin.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 24, 1998
    Inventors: Leo T. Furcht, James B. McCarthy, Sharon M. Wahl, Janice B. Allen, Kevin L. Billups, Jeffrey E. Everett
  • Method for treating acute and chronic inflammatory disorders using polypeptides with fibronectin activity
    Patent number: 5591719
    Abstract: A method for treating acute or chronic inflammatory or autoimmune disorders using polypeptides with fibronectin or related activity is provided. The method involves (administering an amount of) one or more polypeptides corresponding to isolated amino acid residue sequences of the 33 kD carboxy terminal heparin-binding region located on the A chain of fibronectin to effectively suppress inflammation and impairment of tissue function in a patient.
    Type: Grant
    Filed: December 10, 1992
    Date of Patent: January 7, 1997
    Assignees: Regents of the University of Minnesota, The United States of America as represented by the Secretary of Health and Human Services
    Inventors: Leo T. Furcht, James B. McCarthy, Sharon M. Wahl, Janice B. Allen
  • Synthetic fibronectin fragments as inhibitors of retroviral infection
    Patent number: 5545620
    Abstract: The invention includes methods for inhibiting retroviral infections such as HIV. The methods of this invention involve the use of certain fragments of fibronectin and such fragments conjugated to carrier molecules such as ovalbumin to inhibit retroviral infections. The invention also includes novel proteins which comprise fibronectin fragments covalently linked to carrier proteins.
    Type: Grant
    Filed: August 16, 1994
    Date of Patent: August 13, 1996
    Assignees: The United States of America as represented by the Department of Health and Human Services, Reagents of the University of Minnesota
    Inventors: Sharon M. Wahl, James B. McCarthy, Leo T. Furcht
  • Method of treating chronic inflammatory diseases
    Patent number: 5449688
    Abstract: The present invention provides a method for treating chronic inflammatory conditions, including autoimmune diseases by administering an effective amount of an agent, such as a nitric oxide synthase inhibitor, a nitric oxide scavenger, or an inhibitor of tetrahydrobiopterin synthesis, to decrease the amount of nitric oxide present at the site of inflammation.
    Type: Grant
    Filed: March 30, 1993
    Date of Patent: September 12, 1995
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Sharon M. Wahl, Janice B. Allen, Nancy L. McCartney-Francis