Publication number: 20040138238
Abstract: The invention discloses tachykinin receptor antagonists. The tachykinin family of receptors comprising the neurokinins substance P (SP), neurokinin A, and neurokinin B and related neuropeptides that are widely distributed in the peripheral and central nervous system. The invention discloses novel aminopyrimidine derivatives, synthesis and uses thereof for the treatment of diseases mediated directly or indirectly by the tachykinin receptors. These diseases include central nervous system disorders such as anxiety, pain, depression, emesis, in particular cancer chemotherapy induced emesis, respiratory and inflammatory bowel disease and other gastric disorders, asthma, schizophrenia, ophthalmic diseases such as glaucoma, ocular hypotension, neural injury, stroke, cardiac disorders, psoriasis, and migraine. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.
Type:
Application
Filed:
July 24, 2003
Publication date:
July 15, 2004
Inventors:
Dale S. Dhanoa, Oren Becker, Silvia Noiman, Venkitasamy Kesavan, Anurag Sharadendu, Pradyumna Mohanty, Dongli Chen, Srinivasa Rao Cheruku, Alexander Heifetz, Ori Kalid, Yael Marantz, Raphael Nudelman, Sharon Sbacham, Shay Bar-Haim