Patents by Inventor Sharon X. Chen

Sharon X. Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Purification of .alpha.-1 proteinase inhibitor using novel chromatographic separation conditions
    Patent number: 5610285
    Abstract: Cation chromatography with solutions at pH less than 6.0 and low ionic strength can be utilized to purify human .alpha.-1 proteinase inhibitor (.alpha.-1 PI) from biological fluids including plasma and plasma fractions. The cation chromatography takes advantage of the fact that active .alpha.-1 PI does not bind to the cation column under these conditions but other proteins, including denatured .alpha.-1 PI and albumin, do. The effect is that active .alpha.-1 PI flows through the chromatography column leaving the contaminating proteins behind. Recovery of .alpha.-1 PI is high and improvement of purity is dramatic.
    Type: Grant
    Filed: August 24, 1994
    Date of Patent: March 11, 1997
    Assignee: Bayer Corporation
    Inventors: Wytold R. Lebing, Sharon X. Chen