Patents by Inventor Sharyuen Soh

Sharyuen Soh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250109434
    Abstract: A polymer is disposed through a nanopore that encodes a polynucleotide's sequence and includes monomer units that encode nucleotides and include first and second reporter moieties and first and second arresting constructs. The first reporter moiety is translocated into the nanopore's aperture, where a first value of an electrical property of the first reporter moiety is measured while the first arresting construct pauses translocation. The second reporter moiety is translocated into the aperture, where a second value of an electrical property of the second reporter moiety is measured while the second arresting construct pauses translocation. The first value and the second value for each monomer unit is used to identify the nucleotide encoded by that monomer unit; and distinguish the nucleotide encoded by that monomer unit from the nucleotides encoded by adjacent monomer units, including by those that encode the same type of nucleotide as that monomer unit.
    Type: Application
    Filed: September 27, 2024
    Publication date: April 3, 2025
    Applicant: Illumina, Inc.
    Inventors: Hugo Brandão, John Moon, Jeffrey G. Mandell, Erin Garcia, Lisa Savagian, Eunho Noh, Xiangyuan Yang, Sharyuen Soh, Sadeer Salam
  • Publication number: 20230357307
    Abstract: In one aspect, the disclosed technology relates to nanopore sequencing with a polynucleotide comprising a plurality of nucleotides, wherein each nucleotide comprises a linker construct between two positions of the nucleotide, wherein the linker construct optionally comprises a reporter moiety corresponding to the identity of the nucleotide, and wherein the linker construct is a part of the cleavable cyclic loop nucleotide comprising a cleavable site. In some embodiments, the nucleotides further comprise arresting constructs for slowing or halting the polynucleotide translocation through a nanopore.
    Type: Application
    Filed: May 3, 2023
    Publication date: November 9, 2023
    Inventors: Abdul Sadeer Abd Salam, Xiangyuan Yang, Hassan Zakiruddin Bohra, Yin Nah Teo, Min Yen Lee, Ramesh Neelakandan, Jeffrey G. Mandell, Erin Garcia, Sharyuen Soh, Daniel Hartoyo Lukamto