Patents by Inventor Shashank Kosuri

Shashank Kosuri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240355410
    Abstract: Disclosed are systems and methods that provide a framework for machine-assisted discovery of Chondroitinase ABC (ChABC) complexes towards sustained neural regeneration. In some embodiments, the framework may leverage a determination of a diverse set of tailor-made random copolymers that complex and stabilize ChABC at physiological temperature. The copolymer designs, which are based on chain length and/or composition of the copolymers, may be identified using an active machine learning paradigm, which involves, but is not limited to, copolymer synthesis, testing for ChABC thermostability upon copolymer complexation, Gaussian Process Regression modeling and Bayesian optimization. Copolymers are synthesized by automated PET-RAFT, and thermostability of ChABC may be assessed by retained enzyme activity (REA) after a predefined interval of hours at 37° C.
    Type: Application
    Filed: April 25, 2024
    Publication date: October 24, 2024
    Inventors: Adam J. Gormley, Matthew Tamasi, Shashank Kosuri, Michael Anthony Webb, Carlos Hernan Borca, Roshan Anit Patel
  • Patent number: 11685801
    Abstract: The invention provides UV-sensitive monomers, comprising a cyclopropenone-containing group, which acts as a masked dibenzocyclooctyne (DBCO)/dibenzoazocyclooctyne (DIBAC) group. The monomers of the invention can be polymerized for example via reversible addition fragmentation chain transfer (RAFT) polymerization techniques to yield a polymer comprising the masked DBCO/DIBAC group. In certain embodiments, the DBCO/DIBAC group can be unmasked under controlled conditions, allowing conjugation of small molecules and/or macromolecules to the polymer through highly selective and efficient strain-promoted azide alkyne click chemistry (SPAAC).
    Type: Grant
    Filed: November 5, 2019
    Date of Patent: June 27, 2023
    Assignee: Rutgers, the State University of New Jersey
    Inventors: Adam Gormley, Shashank Kosuri
  • Publication number: 20210388138
    Abstract: The invention provides UV-sensitive monomers, comprising a cyclopropenone-containing group, which acts as a masked dibenzocyclooctyne (DBCO)/dibenzoazocyclooctyne (DIBAC) group. The monomers of the invention can be polymerized for example via reversible addition fragmentation chain transfer (RAFT) polymerization techniques to yield a polymer comprising the masked DBCO/DIBAC group. In certain embodiments, the DBCO/DIBAC group can be unmasked under controlled conditions, allowing conjugation of small molecules and/or macromolecules to the polymer through highly selective and efficient strain-promoted azide alkyne click chemistry (SPAAC).
    Type: Application
    Filed: November 5, 2019
    Publication date: December 16, 2021
    Inventors: Adam Gormley, Shashank Kosuri