Abstract: The present invention provides compounds of Formula I?, or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof for treating cellular proliferative disorders (e.g., cancer).

Abstract: In one aspect, a drug delivery device is provided herein including: a monolithic body having a plurality of fluid ducts and at least one outlet duct formed therein; a plurality of drug cartridges attached to the body, the drug cartridges each including a reservoir for accommodating at least one drug wherein, the plurality of fluid ducts is arranged to convey the drugs from the drug cartridges to the at least one outlet duct; and, a needle support spaced from the body, the needle support including a needle configured for insertion into a patient for drug delivery, the needle support including adhesive for releasable securement to a patient, wherein, the needle support is connected to the body by a flexible tether through which passes at least one fluid passageway formed to convey drug from the at least one outlet duct to the needle.

Abstract: In one aspect, a method is provided herein of preparing a drug delivery device, the drug delivery device having a body with at least one fluid duct being open along a first face of the body, the at least one fluid duct for conveying drug from at least one reservoir to a needle configured for injection into a patient, the method including: providing a barrier across the first face of the body to at least cover the at least one fluid duct, wherein the barrier is ultraviolet transmissive; and, exposing the first face of the body to ultraviolet radiation so as to allow the ultraviolet radiation to pass through the barrier and decontaminate the at least one fluid duct.

Abstract: Disclosed are compounds and compositions that modulate cannabinoid receptors, methods of modulating cannabinoid receptors, and methods of treating various disorders related to the modulation of cannabinoid receptors. This disclosure is directed to methods of treating cannabinoid dependence, neuropathy, inflammation, glaucoma, a neurodegenerative disorder, a motor function disorder, a gastrointestinal disorder, hypothermia, emesis, loss of appetite, or anorexia associated with AIDS.

Abstract: Novel cannabinoid ligands represented by the general formulas I, II, and III and methods for preparation and use within which one or more of a fluorescent ligand, nitroxide spin label, metal chelate, biotin moiety, or group with enhanced polarity may be incorporated. The compounds can bind to and modulate the cannabinoid CB1 and CB2 receptors and thereby considered specific ligands for these receptors. Some of the disclosed compounds that bind to cannabinoid CB1 and CB2 receptors can exhibit tight or irreversible binding characteristics for these receptors. Due to the presence of the imaging/diagnostic and/or therapeutic functional groups including fluorescent groups, nitroxide spin labels, metal chelates, biotin moieties, and groups with enhanced polarity, the disclosed compounds may be useful as imaging/diagnostic tools and/or therapeutic agents.

Abstract: The present invention provides compounds of Formula I?, or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof for treating cellular proliferative disorders (e.g., cancer).

Abstract: The present invention relates to fused imidazo pyridine compounds, and pharmaceutically acceptable compositions thereof, useful as BTK inhibitors.

Abstract: Novel cannabinoid ligands represented by the general formulas I, II, and III and methods for preparation and use within which one or more of a fluorescent ligand, nitroxide spin label, metal chelate, biotin moiety, or group with enhanced polarity may be incorporated. The compounds can bind to and modulate the cannabinoid CB1 and CB2 receptors and thereby considered specific ligands for these receptors. Some of the disclosed compounds that bind to cannabinoid CB1 and CB2 receptors can exhibit tight or irreversible binding characteristics for these receptors. Due to the presence of the imaging/diagnostic and/or therapeutic functional groups including fluorescent groups, nitroxide spin labels, metal chelates, biotin moieties, and groups with enhanced polarity, the disclosed compounds may be useful as imaging/diagnostic tools and/or therapeutic agents.

Abstract: Disclosed are compounds and compositions that modulate cannabinoid receptors, methods of modulating cannabinoid receptors, and methods of treating various disorders related to the modulation of cannabinoid receptors. This disclosure is directed to methods of treating cannabinoid dependence, neuropathy, inflammation, glaucoma, a neurodegenerative disorder, a motor function disorder, a gastrointestinal disorder, hypothermia, emesis, loss of appetite, or anorexia associated with AIDS.

Abstract: Systems and methods for generating a blueprint for an enterprise is provided. The system obtains information pertaining to an enterprise from data sources, extracts entities from the information, and identifies relationships across the entities, performs conflict resolution check on the information received from the data sources based on pre-defined rules, identifies one or more missing links in the information. The system further computes a completeness score for the information based on at least one of the conflict resolution check and the missing links, and generates a blueprint of the information and the one or more entities for the enterprise. Authentic data sources are identified from the data sources based on at least one of assigned weight, and one or more instances of, and contribution by, the data sources in the information. The completeness score is computed based on the instances and contribution of the sources in the information.

Abstract: Methods and systems are presented for evaluating performance of a finite or infinite antenna array including a finite number of antennas. Typically, a model is generated for the antenna array, the model including an arbitrarily large antenna array with an arbitrarily large number of model antennas. Each model antenna has features defined by features of antennas of the finite or infinite antenna array. A unit cell is determined for the arbitrarily large antenna, and impedance matrices Zantenna and Zperiodic are computed, Zperiodic representing interactions among the unit cell and the other model antennas. From these matrices, the performance of the finite or infinite antenna array is assessed.

Abstract: Systems and methods for generating a blueprint for an enterprise is provided. The system obtains information pertaining to an enterprise from data sources, extracts entities from the information, and identifies relationships across the entities, performs conflict resolution check on the information received from the data sources based on pre-defined rules, identifies one or more missing links in the information. The system further computes a completeness score for the information based on at least one of the conflict resolution check and the missing links, and generates a blueprint of the information and the one or more entities for the enterprise. Authentic data sources are identified from the data sources based on at least one of assigned weight, and one or more instances of, and contribution by, the data sources in the information. The completeness score is computed based on the instances and contribution of the sources in the information.

Abstract: A droplet coalescing filter cartridge is provided. The filter cartridge includes an outer filter tube and an inner filter tube disposed within the outer filter tube, and is configured to provide parallel filtration of a fluid flow. The filter includes a depth media configured to coalesce fine droplets or aerosols from an air flow. The filter cartridge is suitable for use in a coalescing filter assembly including the filter cartridge and a secondary filter element.

Abstract: Methods and systems are presented for evaluating performance of a finite or infinite antenna array including a finite number of antennas. Typically, a model is generated for the antenna array, the model including an arbitrarily large antenna array with an arbitrarily large number of model antennas. Each model antenna has features defined by features of antennas of the finite or infinite antenna array. A unit cell is determined for the arbitrarily large antenna, and impedance matrices Zantenna and Zperiodic are computed, Zperiodic representing interactions among the unit cell and the other model antennas. From these matrices, the performance of the finite or infinite antenna array is assessed.