Abstract: The invention teaches the unexpected finding that treatment of mesenchymal stem cells with inhibitors of mammalian target of rapamycin (mTOR) lead to enhancement of regenerative and/or anti-inflammatory activity of said stem cells. In one embodiment, rapamycin treatment of mesenchymal stem cells (MSC) is associated with enhanced basal and stimulated production of therapeutic factors. In one embodiment other regenerative activities are enhanced by treatment with inhibitors of mTOR such as angiogenesis, neurogenesis, protection from apoptosis, and immune modulation.

Abstract: Disclosed are means, methods and compositions of matter useful for treatment of inflammatory and/or viral mediated disease through administration of cellular populations subsequent to modulation of complement pathway. In one embodiment, patients with COVID-19 who are eligible for stem cell therapy are pretreated with modulators of complement activity in order to reduce inflammation and to augment activity of said stem cell therapy. Activity of said stem cell therapy includes protection of pulmonary cells from dysfunction/death, stimulation of regenerative/trophic activities, reduction of inflammation, and induction of immune modulation.

Abstract: Disclosed are compositions of matter, protocols, and combination therapies useful for reduction of pulmonary inflammation associated with conditions such as acute respiratory distress syndrome (ARDS), ventilator induced inflammation, and infectious disease induced inflammation. In one embodiment the invention provides therapeutic gases which induce anti-apoptotic, anti-inflammatory, and immune modulatory properties in the pulmonary environment of a patient in need of therapy.

Abstract: Disclosed are compositions of matter, cells, and therapeutic protocols useful for treatment of acute respiratory distress syndrome (ARDS). In some embodiments the invention teaches treatment of ARDS caused by viruses including COVID-19 through administration of an immature population of dendritic cells at a concentration and frequency to inhibit pulmonary inflammation, alveolar leakage, and loss of pulmonary function. In some embodiments immature dendritic cells are generated by culture of autologous and/or allogeneic monocytes with IL-4 and GM-CSF without a maturation step. In other embodiments, generation of immature dendritic cells is performed by administration on NF-kappa B inhibitors. In other embodiments dendritic cells are utilized in an immature form to stimulate generation of T regulatory cells.

Abstract: Described are means, methods and compositions of matter for treatment of acute respiratory distress syndrome (ARDS) by enhancement of T regulatory (Treg) number and/or efficacy. In one embodiment of the invention, exogenous Tregs are administered. In another embodiment, enhanced endogenous Tregs are provided using methods including administration of low dose interleukin-2, administration of other cytokines, and administration of cells which stimulate Treg generation such as mesenchymal stem cells.

Abstract: A system for selectively manipulating a mobile device when the mobile device is present within one or more defined zones within an area. The system comprises a control device transmitting a signal, with the signal having a decreasing signal strength as distance from the control device increases. The system additional comprises one or more profiles stored in a memory for determining the one or more defined zones based on one or more values, each value corresponding to a particular signal strength of the signal, and at least one software application executing on the mobile device. The application is configured for accessing the profiles from a memory and receiving, from the mobile device, an indication of the signal received at the mobile device and a signal strength of the received signal, and selectively manipulating the mobile device as a function of the signal strength and the one or more profiles.

Abstract: A system for selectively manipulating a mobile device when the mobile device is present within one or more defined zones within an area. The system comprises a control device transmitting a signal, with the signal having a decreasing signal strength as distance from the control device increases. The system additional comprises one or more profiles stored in a memory for determining the one or more defined zones based on one or more values, each value corresponding to a particular signal strength of the signal, and at least one software application executing on the mobile device. The application is configured for accessing the profiles from a memory and receiving, from the mobile device, an indication of the signal received at the mobile device and a signal strength of the received signal, and selectively manipulating the mobile device as a function of the signal strength and the one or more profiles.

Abstract: A chamber device for analyzing living cell(s). The chamber device includes a base and a lid that when reversibly pressed closed create a chamber. The base is configured with an optically transparent well to contain at least one cell. The lid has a breadth greater than the base and is configured to contain at least one sensor. The lid is further configured with a lip that when pressed between the lid and the base creates an impermeable seal. The base and the lid are configured so that, when closed and in use, the sensor remains spatially apart from the at least one cell.