Patents by Inventor Shashi K. Murthy

Shashi K. Murthy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200308523
    Abstract: The invention provides cell culture chambers and methods of use thereof. In certain embodiments, the cell culture chambers and methods provide for an expansion and stimulation of T-cells using autologous antigen-presented cells to provide a therapeutic T-cell product that can mobilize a patient's own immune system in a manner that selectively targets a patient's tumor.
    Type: Application
    Filed: June 27, 2017
    Publication date: October 1, 2020
    Inventor: Shashi K. Murthy
  • Patent number: 10731131
    Abstract: Devices, systems, and methods can be used for the automated production of dendritic cells (DC) from dendritic cell progenitors, such as monocytes obtained from peripheral blood. The invention makes it possible to obtain sufficient quantities of a subject's own DC for use in preparing and characterizing vaccines, for activating and characterizing the activation state of the subject's immune response, and to aid in preventing and/or treating cancer or infectious disease.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: August 4, 2020
    Assignee: NORTHEASTERN UNIVERSITY
    Inventors: Shashi K. Murthy, Bradley B. Collier
  • Publication number: 20190083979
    Abstract: An embodiment is a scientific fluidic device and a method of assembly of single and multilayer fluidic devices via laser cut and assembly of double sided adhesives. The device includes a member defining a cavity and having two sides, both sides including an adhesive compound, and at least one substrate defining at least two plenums and coupling to the member, forming a flow path. The components of the fluidic device are produced via laser cut and assembly methods. The fluidic device remains intact via adhesive coupling between the substrate(s), member(s), and membrane(s). Altogether, the fluidic device requires assembly that is efficient and economical, resulting in high throughput manufacturing of the fluidic devices.
    Type: Application
    Filed: August 31, 2018
    Publication date: March 21, 2019
    Inventors: Sanjin Hosic, Ryan A. Koppes, Shashi K. Murthy, Abigail N. Koppes, Jonathan R. Soucy
  • Publication number: 20180251723
    Abstract: Devices, systems, and methods can be used for the automated production of dendritic cells (DC) from dendritic cell progenitors, such as monocytes obtained from peripheral blood, and the automated generation of immunotherapeutic products from those dendritic cells, all within a closed system. The invention makes it possible to obtain sufficient quantities of a subject's own DC for use in preparing and characterizing vaccines, for activating and characterizing the activation state of the subject's immune response, and to aid in preventing and/or treating cancer or infectious disease.
    Type: Application
    Filed: May 3, 2018
    Publication date: September 6, 2018
    Inventor: Shashi K. Murthy
  • Publication number: 20180171296
    Abstract: Devices, systems, and methods can be used for the automated production of dendritic cells (DC) from dendritic cell progenitors, such as monocytes obtained from peripheral blood. The invention makes it possible to obtain sufficient quantities of a subject's own DC for use in preparing and characterizing vaccines, for activating and characterizing the activation state of the subject's immune response, and to aid in preventing and/or treating cancer or infectious disease.
    Type: Application
    Filed: June 29, 2016
    Publication date: June 21, 2018
    Inventors: Shashi K. Murthy, Bradley B. Collier
  • Patent number: 9927334
    Abstract: Disclosed herein are hydrogel compositions and methods of making hydrogel compositions. Furthermore, methods of specifically capturing and releasing biological materials from a sample using the disclosed hydrogel compositions are disclosed, including methods of utilizing the compositions in microfluidic devices.
    Type: Grant
    Filed: February 3, 2012
    Date of Patent: March 27, 2018
    Assignee: Northeastern University
    Inventors: Shashi K. Murthy, Adam Hatch, George Hansmann
  • Publication number: 20140065688
    Abstract: Disclosed herein are devices for the magnetophoretic separation of target biological materials including a separation chamber that has a plurality of channels, and one or more wires carrying a current, the wires generating a magnetic force that deflects magnetically-labeled target biological materials into a buffer stream. In addition, methods of separating target biological materials from non-target biological materials in a sample are disclosed. Finally, methods for constructing a magnetophoretic separation device are disclosed.
    Type: Application
    Filed: February 3, 2012
    Publication date: March 6, 2014
    Applicant: NORTHEASTERN UNIVERSITY
    Inventors: Shashi K. Murthy, Laura H. Lewis, Brian D. Plouffe
  • Publication number: 20140057280
    Abstract: Disclosed herein are hydrogel compositions and methods of making hydrogel compositions. Furthermore, methods of specifically capturing and releasing biological materials from a sample using the disclosed hydrogel compositions are disclosed, including methods of utilizing the compositions in microfluidic devices.
    Type: Application
    Filed: February 3, 2012
    Publication date: February 27, 2014
    Applicant: NORTHEASTERN UNIVERSITY
    Inventors: Shashi K. Murthy, Adam Hatch, George Hansmann
  • Patent number: 6887578
    Abstract: Hot-filament chemical vapor deposition has been used to deposit copolymer thin films consisting of fluorocarbon and siloxane groups. The presence of covalent bonds between the fluorocarbon and organosilicon moieties in the thin film has been confirmed by Infrared, X-ray Photoelectron (XPS) and solid-state 29Si, 19F, and 13C Nuclear Magnetic Resonance (NMR) spectroscopy. The film structure consists of chains with linear and cyclic siloxane groups and CF2 groups as repeat units.
    Type: Grant
    Filed: October 29, 2002
    Date of Patent: May 3, 2005
    Assignee: Massachusetts Institute of Technology
    Inventors: Karen K. Gleason, Shashi K. Murthy
  • Publication number: 20030138645
    Abstract: Hot-filament chemical vapor deposition has been used to deposit copolymer thin films consisting of fluorocarbon and siloxane groups. The presence of covalent bonds between the fluorocarbon and organosilicon moieties in the thin film has been confirmed by Infrared, X-ray Photoelectron (XPS) and solid-state 29Si, 19F, and 13C Nuclear Magnetic Resonance (NMR) spectroscopy. The film structure consists of chains with linear and cyclic siloxane groups and CF2 groups as repeat units.
    Type: Application
    Filed: October 29, 2002
    Publication date: July 24, 2003
    Inventors: Karen K. Gleason, Shashi K. Murthy