Patents by Inventor Shau-Chun Wang

Shau-Chun Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220339626
    Abstract: The present disclosure provides a microfluidic device, including a bottom substrate, an electrowetting-on-dielectric (EWOD) chip, a circuit board, a dielectric film, and a motor. The EWOD chip is disposed on the bottom substrate, and the circuit board is arranged on the EWOD chip. The circuit board includes a circuit area that is electrically connected to the EWOD chip, and the empty area is adjacent to the circuit area and the EWOD chip is exposed. The dielectric film is disposed on the empty area of the circuit board and covers the exposed EWOD chip. The motor is disposed under the bottom substrate, and one end of the motor has a magnetic structure, so that the magnetic structure can move closer to or away from the bottom substrate.
    Type: Application
    Filed: June 25, 2021
    Publication date: October 27, 2022
    Inventors: Shau-Chun WANG, Lai-Kwan CHAU, Yuan-Yu CHEN
  • Publication number: 20210252502
    Abstract: A microfluidic detection unit comprises at least one fluid injection section, a fluid storage section and a detection section. Each fluid injection section defines a fluid outlet; the fluid storage section is in gas communication with the atmosphere and defines a fluid inlet; the detection section defines a first end in communication with the fluid outlet and a second end in communication with the fluid inlet. A height difference is defined between the fluid outlet and the fluid inlet along the direction of gravity. When a first fluid is injected from the at least one fluid injection section, the first fluid is driven by gravity to pass through the detection section and accumulate to form a droplet at the fluid inlet, such that a state of fluid pressure equilibrium of the first fluid is established.
    Type: Application
    Filed: June 10, 2019
    Publication date: August 19, 2021
    Inventors: Yu-Chung HUANG, Yi-Li SUN, Ting-Chou CHANG, Jhy-Wen WU, Nan-Kuang YAO, Lai-Kwan CHAU, Shau-Chun WANG, Ying Ting CHEN
  • Patent number: 9952196
    Abstract: A method for detecting albumin based on a colorimetric assay and a system thereof are disclosed. Gold nanoparticles are added into the sample preparing device having a sample without spectroscopic tags, wherein the sample without spectroscopic tags is formed as the alkaline solution to avoid the interference substances adhering on the gold nanoparticles. The gold nanoparticles are concentrated by using the microfluidic concentrator with the circular ion exchange membrane by applying an external electric field across two electrodes. The image of the concentrated gold nanoparticles is captured by the image capturing device for measuring the saturation intensities of the image, wherein there is a relation between the saturation intensities and the concentration of the albumin in the sample without spectroscopic tags. The concentration of the albumin of the sample without spectroscopic tags is obtained by the relation and the measured saturation intensities.
    Type: Grant
    Filed: December 31, 2015
    Date of Patent: April 24, 2018
    Assignee: National Chung Cheng University
    Inventors: Shau-Chun Wang, Teh-Sheng Lai, Ting-Chou Chang
  • Publication number: 20170146507
    Abstract: A method for detecting albumin based on a colorimetric assay and a system thereof are disclosed. Gold nanoparticles are added into the sample preparing device having a sample without spectroscopic tags, wherein the sample without spectroscopic tags is formed as the alkaline solution to avoid the interference substances adhering on the gold nanoparticles. The gold nanoparticles are concentrated by using the microfluidic concentrator with the circular ion exchange membrane by applying an external electric field across two electrodes. The image of the concentrated gold nanoparticles is captured by the image capturing device for measuring the saturation intensities of the image, wherein there is a relation between the saturation intensities and the concentration of the albumin in the sample without spectroscopic tags. The concentration of the albumin of the sample without spectroscopic tags is obtained by the relation and the measured saturation intensities.
    Type: Application
    Filed: December 31, 2015
    Publication date: May 25, 2017
    Inventors: SHAU-CHUN WANG, TEH-SHENG LAI, TING-CHOU CHANG
  • Patent number: 9506861
    Abstract: A method for obtaining the binding kinetic rate constants using fiber optic particle plasmon resonance (FOPPR) sensor, suitable for a test solution with two or more concentrations, which employs the following major steps: providing one FOPPR sensor instrument system, obtaining optical time-resolved signal intensities starting at the initial time to the steady state of the two or more regions, substituting the measured signal intensity values into the formula which is derived by using the pseudo-first order rate equation model. In addition, this method measures the temporal signal intensity evolution under static conditions as the samples are quickly loaded. As a result, unlike the conventional device where the sample is continuously infused, the method is able to measure the association and dissociation rate constants of which the upper bounds are not limited by the sample flow rate.
    Type: Grant
    Filed: October 25, 2013
    Date of Patent: November 29, 2016
    Assignee: NATIONAL CHUNG CHENG UNIVERSITY
    Inventors: Shau-Chun Wang, Lai-Kwan Chau, Ting-Chou Chang, Chao-Ching Wu
  • Patent number: 9470625
    Abstract: A method of examining the purity of dendrimers is revealed. It comprises steps of measuring a light scattering intensity of a set of pure standards having a specific molecular weight with a static laser light scattering detector by use of flow injection polymer analysis; establishing a scaling relation by doing a regression of a ratio of the light scattering intensity per concentration (I/c) against molecular weight (M.W.); measuring the light scattering intensity of a dendrimer to be tested having the same unit and surface-modified functional group as the set of pure standards, and examining the purity of the dendrimer to be tested according to the scaling relation.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: October 18, 2016
    Assignee: National Chung Cheng University
    Inventors: Shau-Chun Wang, Hui-Yu Tseng, Chai-Ling Kao
  • Patent number: 8765056
    Abstract: A method for detecting optical signals, a microfluidic mixing chip having light emitting compound and a system thereof are provided. The microfluidic mixing system comprises the microfluidic mixing chip, an electrode pairs and a power supplier. The microfluidic mixing chip comprises a first side cavity, a second side cavity and a mixing cavity. The mixing cavity is disposed between the first side cavity and the second side cavity. The mixing cavity further contains the light emitting compound, a catalyst and a redox reagent. The electrode pair is respectively disposed to the first side cavity and the second cavity. The power supplier supplies a power source with high frequency alternating current electric field. By utilizing the power source with alternating current electric field, the light emitting compound, the redox reagent and the catalyst are mixed in the mixing cavity to generate a chemiluminescence or bioluminescence optical signal to detect.
    Type: Grant
    Filed: December 3, 2010
    Date of Patent: July 1, 2014
    Assignee: National Chung Cheng University
    Inventors: Shau-Chun Wang, Pei-Ching Hung, Chun-Yi Yeh
  • Publication number: 20140051188
    Abstract: A method for obtaining the binding kinetic rate constants using fiber optic particle plasmon resonance (FOPPR) sensor, suitable for a test solution with two or more concentrations, which employs the following major steps: providing one FOPPR sensor instrument system, obtaining optical time-resolved signal intensities starting at the initial time to the steady state of the two or more regions, substituting the measured signal intensity values into the formula which is derived by using the pseudo-first order rate equation model. In addition, this method measures the temporal signal intensity evolution under static conditions as the samples are quickly loaded. As a result, unlike the conventional device where the sample is continuously infused, the method is able to measure the association and dissociation rate constants of which the upper bounds are not limited by the sample flow rate.
    Type: Application
    Filed: October 25, 2013
    Publication date: February 20, 2014
    Applicant: NATIONAL CHUNG CHENG UNIVERSITY
    Inventors: SHAU-CHUN WANG, LAI-KWAN CHAU, TING-CHOU CHANG, CHAO-CHING WU
  • Publication number: 20130122608
    Abstract: A method for estimating binding kinetic rate constants by using a fiber optic particle plasmon resonance (FOPPR) sensor mainly employs the steps of: providing a FOPPR sensor instrument system, obtaining optical signal intensities at an initial time and steady state signal intensities of first and second regions in an intensity versus time graph separately, substituting the measured signal intensity values into a formula derived by using a pseudo-first order rate equation model. According to this method, no fluorophore labeling is required. In addition, this method measures a temporal signal intensity evolution under static conditions as the samples are quickly loaded. As a result, unlike the conventional device where the sample is continuously infused, the method is able to measure binding and decomposition rate constants whose upper limit is not limited by a sample flow rate.
    Type: Application
    Filed: May 14, 2012
    Publication date: May 16, 2013
    Applicant: NATIONAL CHUNG CHENG UNIVERSITY
    Inventors: SHAU-CHUN WANG, LAI-KWAN CHAU, TING-CHOU CHANG, CHAO-CHING WU
  • Patent number: 8349275
    Abstract: A microfluidic device with microstructure includes a channel for accommodating an electrolytic solution therein and at least one microstructure formed in the channel. When an alternating-current signal is input to the microfluidic device so that a surface of the microstructure is polarized by a generated electric field, ions having polarity reverse to that of an electrolytic solution will migrate to the surface of the microstructure to form a field-induced electrical double layer to result in electro-osmotic flows at the corners at two sides of the microstructure, which causes formation of relatively fierce circular vortices in the solution. A sensing system and a sensing method using the microfluidic device with microstructure are also disclosed.
    Type: Grant
    Filed: January 23, 2009
    Date of Patent: January 8, 2013
    Assignee: National Chung Cheng University
    Inventors: Shau-Chun Wang, Lai-Kwan Chau, Wen-Hsin Hsieh, Chia-Yu Lee
  • Publication number: 20110294225
    Abstract: A method for detecting optical signals, a microfluidic mixing chip having light emitting compound and a system thereof are provided. The microfluidic mixing system comprises the microfluidic mixing chip, an electrode pairs and a power supplier. The microfluidic mixing chip comprises a first side cavity, a second side cavity and a mixing cavity. The mixing cavity is disposed between the first side cavity and the second side cavity. The mixing cavity further contains the light emitting compound, a catalyst and a redox reagent. The electrode pair is respectively disposed to the first side cavity and the second cavity. The power supplier supplies a power source with high frequency alternating current electric field. By utilizing the power source with alternating current electric field, the light emitting compound, the redox reagent and the catalyst are mixed in the mixing cavity to generate a chemiluminescence or bioluminescence optical signal to detect.
    Type: Application
    Filed: December 3, 2010
    Publication date: December 1, 2011
    Applicant: NATIONAL CHUNG CHENG UNIVERSITY
    Inventors: Shau-Chun WANG, Pei-Ching HUNG, Chun-Yi YEH
  • Publication number: 20100264040
    Abstract: The present invention provides a method for concentrating particles or molecules and an apparatus thereof. The apparatus comprises a substrate, a conducting granule having nano-pores or nano-channels capable of permitting ion permeation, an electrolyte solution comprising counter-ions having an opposite electric property to the conducting granule, and an external field. Wherein, particles or molecules to be concentrated have an identical electric property as the conducting granule at a predefined pH value, and are added into the electrolyte solution with the predefined pH value. While the external electric field is applied across the reservoir where the conducting granule is sitting, the counter-ions exit from the nano-pores or nano-channels and such that a transient ion super-concentration phenomenon occurs at an ejecting pole on the conducting granule so as to concentrate the particles or molecules. Hence the present invention has potential application in bead-based molecular assays.
    Type: Application
    Filed: June 30, 2010
    Publication date: October 21, 2010
    Applicant: NATIONAL CHUNG CHENG UNIVERSITY
    Inventors: SHAU-CHUN WANG, Hsueh-Chia Chang, Hsiao-Ping Chen, Chun-Ming Chang
  • Publication number: 20090277792
    Abstract: The present invention discloses a method for concentrating charged particles and an apparatus thereof. The method comprises: providing a substrate comprising a reservoir; disposing a conducting granule in the reservoir, the conducting granule being negatively charged or positively charged and comprising nano-pores or nano-channels capable of permitting ion permeation; disposing a buffer solution in the reservoir, the buffer solution comprising counter-ions having an opposite electric property to the conducting granule; adding the charged particles into the buffer solution, the charged particles being co-ions having an identical electric property as the conducting granule; and applying an external electric field on the conducting granule.
    Type: Application
    Filed: March 30, 2009
    Publication date: November 12, 2009
    Applicant: NATIONAL CHUNG CHENG UNIVERSITY
    Inventors: Shau-Chun Wang, Hsueh-Chia Chang, Hsiao-Ping Chen, Hsien-Hung Wei, Chun-Ching Yu, Min-Hsuan Tsai
  • Publication number: 20090190877
    Abstract: A microfluidic device with microstructure includes a channel for accommodating an electrolytic solution therein and at least one microstructure formed in the channel. When an alternating-current signal is input to the microfluidic device so that a surface of the microstructure is polarized by a generated electric field, ions having polarity reverse to that of an electrolytic solution will migrate to the surface of the microstructure to form a field-induced electrical double layer to result in electro-osmotic flows at the corners at two sides of the microstructure, which causes formation of relatively fierce circular vortices in the solution. A sensing system and a sensing method using the microfluidic device with microstructure are also disclosed.
    Type: Application
    Filed: January 23, 2009
    Publication date: July 30, 2009
    Applicant: NATIONAL CHUNG CHENG UNIVERSITY
    Inventors: Shau-Chun Wang, Lai-Kwan Chau, Wen-Hsin Hsieh, Chia-Yu Lee
  • Publication number: 20080316854
    Abstract: A microfluid mixer is provided. The non-linear electrokineticsis is applied to the design of the microfluid mixer. The microfluid mixer comprises a first and a second microfluidic elements, a mixing reservoir, and a micro channel unit, wherein the micro channel unit has at least two control channels for respectively connecting the first and the second microfluidic elements and the mixing reservoir. When two microfluids are mixed in the mixing reservoir, the electro-osmosis fluid field of the microfluids in the control channel of the mixing reservoir is changed by applying AC signal, such that powerful chaotic mixing effect is therefore produced by the two microfluids in the mixing reservoir.
    Type: Application
    Filed: March 18, 2008
    Publication date: December 25, 2008
    Applicant: NATIONAL CHUNG CHENG UNIVERSITY
    Inventors: Shau-Chun Wang, Hsiao-Ping Chen, Chia Yu Lee, Hsueh-Chia Chang