Patents by Inventor Shaukat Ali
Shaukat Ali has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9622966Abstract: A gastroretentive composition comprises a mixture comprising an active ingredient component and an excipient component. The excipient component comprises a first water-soluble reaction product produced from a precursor comprising a vinyl group, and a copolymer of a polyalkylene glycol and a second water-soluble reaction product produced from a precursor comprising a vinyl group. A method of forming the gastroretentive composition comprises the steps of providing the active ingredient component and the excipient component, and mixing the active ingredient component and the excipient component to form a mixture. The mixture is aggregated to form an aggregation that is dry granulated to form a plurality of granules. The plurality of granules is processed to form the gastroretentive composition.Type: GrantFiled: December 26, 2007Date of Patent: April 18, 2017Assignee: BASF CORPORATIONInventors: Shaukat Ali, Anisul Quadir
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Patent number: 9023382Abstract: A medicament carrier composition includes a medicament and a polymer component including a polyvinylpyrrolidone having a weight average molecular weight of at least 700,000 g/mol. The medicament carrier composition has a viscosity of from 500 to 5,000 cps at 250 C, is substantially free of cellulose, and includes an auxiliary polymer. The medicament carrier composition is used to form a film that is also substantially free of cellulose. The film has a consistent thickness and size, and an increased flexibility and increased moisture resistance due to the polyvinylpyrrolidone. The medicament carrier composition is also used in a method of forming the film. The method includes the steps of providing the medicament and the polymer component. The method also includes the step of combining the polymer component and the medicament to form the medicament carrier composition. The method further includes the step of drying the medicament carrier composition to form the film.Type: GrantFiled: April 24, 2006Date of Patent: May 5, 2015Assignee: BASF CorporationInventors: Shaukat Ali, Anisul Quadir
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Publication number: 20130017241Abstract: An encapsulated chlorine dioxide generator is provided. The encapsulated generator includes a core particle that includes a metal chlorite and a solid acid. The encapsulated generator also includes a protective layer that is disposed about at least a portion of the core particle. The protective layer includes a copolymer of polyvinyl alcohol and a polyalkylene glycol. The encapsulated generator is formed in a method including the steps of forming the core particle and disposing the protective layer about the core particle. The encapsulated generator is also used in a method of cleaning an environment. The method of cleaning the environment includes the steps of providing the encapsulated generator and forming chlorine dioxide from the encapsulated chlorine dioxide generator to clean the environment.Type: ApplicationFiled: February 1, 2011Publication date: January 17, 2013Applicant: BASF SEInventors: Kim Andrews, Shaukat Ali, Jesse Jefferis, James S. Dailey, Charles O. Onyiuke, Keith A. Hirsch
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Publication number: 20120269866Abstract: A gastroretentive composition comprises a mixture comprising an active ingredient component and an excipient component. The excipient component comprises a first water-soluble reaction product produced from a precursor comprising a vinyl group, and a copolymer of a polyalkylene glycol and a second water-soluble reaction product produced from a precursor comprising a vinyl group. A method of forming the gastroretentive composition comprises the steps of providing the active ingredient component and the excipient component, and mixing the active ingredient component and the excipient component to form a mixture. The mixture is aggregated to form an aggregation that is dry granulated to form a plurality of granules. The plurality of granules is processed to form the gastroretentive composition.Type: ApplicationFiled: December 26, 2007Publication date: October 25, 2012Inventors: Shaukat Ali, Carlos Santos, Anisul Quadir
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Publication number: 20090053285Abstract: A medicament carrier composition includes a medicament and a polymer component including a polyvinylpyrrolidone having a weight average molecular weight of at least 700,000 g/mol. The medicament carrier composition has a viscosity of from 500 to 5,000 cps at 250 C, is substantially free of cellulose, and includes an auxiliary polymer. The medicament carrier composition is used to form a film that is also substantially free of cellulose. The film has a consistent thickness and size, and an increased flexibility and increased moisture resistance due to the polyvinylpyrrolidone. The medicament carrier composition is also used in a method of forming the film. The method includes the steps of providing the medicament and the polymer component. The method also includes the step of combining the polymer component and the medicament to form the medicament carrier composition. The method further includes the step of drying the medicament carrier composition to form the film.Type: ApplicationFiled: April 24, 2006Publication date: February 26, 2009Inventors: Shaukat Ali, Anisul Quadir
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Patent number: 6500461Abstract: This invention provides vehicles capable of delivering high concentrations of poorly hydrophilic/poorly lipophilic compounds to animals, by combining compounds having biocompatible hydrophobic domains with conjugates having both hydrophobic and hydrophilic regions. Such formulations are suitable for a number of uses in animals, particularly the administration thereto of high concentrations of therapeutically useful compound, without an undue level of side effects.Type: GrantFiled: May 19, 1999Date of Patent: December 31, 2002Assignee: The Liposome CompanyInventors: Walter Perkins, Xingong Li, Donald Hirsh, Eric Mayhew, Imran Ahmad, Shaukat Ali, Andrew Janoff
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Patent number: 6482850Abstract: Provided herein is a taxane having a hydrocarbon attached at the 2′ and/or 7 positions, the hydrocarbon's alpha position being occupied by a “hydrolysis-promoting group” (“HPG”). In one embodiment, the hydrolysis promoting group is stereospecifically attached to the &agr;-carbon of the hydrophobic taxane. The Substitution of an HPG for the methylene unit ordinarily occupying the alpha position allows for enhanced in vivo hydrolysis of the hydrocarbon-taxane bond, and hence, for enhanced taxane therapeutic activity. Also provided herein are taxane-containing compositions, and methods of administering taxanes to animals, including those afflicted with cancers or inflammatory diseases.Type: GrantFiled: August 29, 2001Date of Patent: November 19, 2002Assignee: The Liposome CompanyInventors: Shaukat Ali, J. Craig Franklin, Imran Ahmad, Eric Mayhew, Soumendu Bhattacharya, Gil Koehane, Andrew S. Janoff
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Patent number: 6392063Abstract: Provided herein is a taxane having a hydrocarbon attached at the 2′ and/or 7 positions, the hydrocarbon's alpha position being occupied by a “hydrolysis-promoting group” (“HPG”). In one embodiment, the hydrolysis promoting group is stereospecifically attached to the a-carbon of the hydrophobic taxane. The Substitution of an HPG for the methylene unit ordinarily occupying the alpha position allows for enhanced in vivo hydrolysis of the hydrocarbon-taxane bond, and hence, for enhanced taxane therapeutic activity. Also provided herein are taxane-containing compositions, and methods of administering taxanes to animals, including those afflicted with cancers or inflammatory diseases.Type: GrantFiled: July 19, 2000Date of Patent: May 21, 2002Assignee: The Liposome Company, Inc.Inventors: Shaukat Ali, J. Craig Franklin, Imran Ahmad, Eric Mayhew, Soumendu Bhattacharya, Gil Koehane, Andrew S. Janoff
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Publication number: 20020052518Abstract: Provided herein is a taxane having a hydrocarbon attached at the 2′ and/or 7 positions, the hydrocarbon's alpha position being occupied by a “hydrolysis-promoting group” (“HPG”). In one embodiment, the hydrolysis promoting group is stereospecifically attached to the &agr;-carbon of the hydrophobic taxane. The Substitution of an HPG for the methylene unit ordinarily occupying the alpha position allows for enhanced in vivo hydrolysis of the hydrocarbon-taxane bond, and hence, for enhanced taxane therapeutic activity. Also provided herein are taxane-containing compositions, and methods of administering taxanes to animals, including those afflicted with cancers or inflammatory diseases.Type: ApplicationFiled: August 29, 2001Publication date: May 2, 2002Inventors: Shaukat Ali, J. Craig Franklin, Imran Ahmad, Eric Mayhew, Soumendu Bhattacharya, Gil Koehane, Andrew S. Janoff
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Publication number: 20020034536Abstract: This invention provides vehicles capable of delivering high concentrations of poorly hydrophilic/poorly lipophilic compounds to animals, by combining compounds having biocompatible hydrophobic domains with conjugates having both hydrophobic and hydrophilic regions. Such formulations are suitable for a number of uses in animals, particularly the administration thereto of high concentrations of therapeutically useful compound, without an undue level of side effects.Type: ApplicationFiled: May 19, 1999Publication date: March 21, 2002Inventors: WALTER PERKINS, XINGONG LI, DONALD HIRSH, ERIC MAYHEW, IMRAN AHMAD, SHAUKAT ALI, ANDREW JANOFF
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Patent number: 6339069Abstract: Peptide-lipid conjugates are incorporated into liposomes so as to selectively destabilize the liposomes in the vicinity of target peptidase-secreting cells, and hence, to deliver the liposomes to the vicinity of the target cells, or directly into the cells. The liposomes can thus be used to treat mammals for diseases, disorders or conditions, e.g., tumors, microbial infection and inflammations, characterized by the occurrence of peptidase-secreting cells.Type: GrantFiled: June 29, 1999Date of Patent: January 15, 2002Assignee: Elan PharmaceuticalsTechnologies, Inc.Inventors: Paul R. Meers, Charles Pak, Shaukat Ali, Andrew Janoff, J. Craig Franklin, Ravi K. Erukulla, Donna Cabral-Lilly, Patrick L. Ahl
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Patent number: 6294191Abstract: This invention provides liposomes containing one or more N-acylated phosphatidylethanolamines, such liposomes being useful for localizing the delivery of bioactive agents to cells.Type: GrantFiled: January 19, 2000Date of Patent: September 25, 2001Assignee: The Liposome Company, Inc.Inventors: Paul R. Meers, Tong Shangguan, Shaukat Ali, Andrew Janoff, Charles Pak
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Patent number: 6143716Abstract: Peptide-lipid conjugates are incorporated into liposomes so as to selectively destabilize the liposomes in the vicinity of target peptidase-secreting cells, and hence, to deliver the liposomes to the vicinity of the target cells, or directly into the cells. The liposomes can thus be used to treat mammals for diseases, disorders or conditions, e.g., tumors, microbial infection and inflammations, characterized by the occurrence of peptidase-secreting cells.Type: GrantFiled: October 7, 1998Date of Patent: November 7, 2000Assignee: The Liposome Company, Inc.Inventors: Paul R. Meers, Charles Pak, Shaukat Ali, Andrew Janoff, J. Craig Franklin, Ravi K. Erukulla, Donna Cabral-Lilly
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Patent number: 6120797Abstract: This invention provides liposomes containing one or more N-acylated phosphatidylethanolamines, such liposomes being useful for localizing the delivery of bioactive agents to cells.Type: GrantFiled: October 15, 1997Date of Patent: September 19, 2000Assignee: The Liposome Company, Inc.Inventors: Paul R. Meers, Tong Shangguan, Shaukat Ali, Andrew Janoff, Charles Pak
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Patent number: 6107332Abstract: Provided herein is a taxane having a hydrocarbon attached at the 2' and/or 7 positions, the hydrocarbon's alpha position being occupied by a "hydrolysis-promoting group" ("HPG"). In one embodiment, the hydrolysis promoting group is stereospecifically attached to the .alpha.-carbon of the hydrophobic taxane. The Substitution of an HPG for the methylene unit ordinarily occupying the alpha position allows for enhanced in vivo hydrolysis of the hydrocarbon-taxane bond, and hence, for enhanced taxane therapeutic activity. Also provided herein are taxane-containing compositions, and methods of administering taxanes to animals, including those afflicted with cancers or inflammatory diseases.Type: GrantFiled: February 12, 1999Date of Patent: August 22, 2000Assignee: The Liposome Company, Inc.Inventors: Shaukat Ali, J. Craig Franklin, Imran Ahmad, Eric Mayhew, Soumendu Bhattacharya, Gil Koehane, Andrew S. Janoff
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Patent number: 6087325Abstract: Peptide-lipid conjugates are incorporated into liposomes so as to selectively destabilize the liposomes in the vicinity of target peptidase-secreting cells, and hence, to deliver the liposomes to the vicinity of the target cells, or directly into the cells. The liposomes can thus be used to treat mammals for diseases, disorders or conditions, e.g., tumors, microbial infection and inflammations, characterized by the occurrence of peptidase-secreting cells.Type: GrantFiled: October 15, 1997Date of Patent: July 11, 2000Assignee: The Liposome Company, Inc.Inventors: Paul R. Meers, Charles Pak, Shaukat Ali, Andrew Janoff, J. Craig Franklin, Ravi K. Erukulla, Donna Cabral-Lilly
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Patent number: 6051600Abstract: Provided herein is a taxane having a hydrocarbon attached at the 2' and/or 7 positions, the hydrocarbon's alpha position being occupied by a "hydrolysis-promoting group" ("HPG"). Substitution of an HPG for the methylene unit ordinarily occupying the alpha position allows for enhanced in vivo hydrolysis of the hydrocarbon-taxane bond, and hence, for enhanced taxane therapeutic activity. Also provided herein are taxane-containing compositions, and methods of administering taxanes to animals, including those afflicted with cancers.Type: GrantFiled: February 27, 1997Date of Patent: April 18, 2000Inventors: Eric Mayhew, Shaukat Ali, Andrew S. Janoff
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Patent number: 5703117Abstract: Provided herein is a taxane having a hydrocarbon attached at the 2' and/or 7 positions, the hydrocarbon's alpha position being occupied by a "hydrolysis-promoting group" ("HPG"). Substitution of an HPG for the methylene unit ordinarily occupying the alpha position allows for enhanced in vivo hydrolysis of the hydrocarbon-taxane bond, and hence, for enhanced taxane therapeutic activity. Also provided herein are taxane-containing compositions, and methods of administering taxanes to animals, including those afflicted with cancers.Type: GrantFiled: September 12, 1996Date of Patent: December 30, 1997Assignee: The Liposome Company, Inc.Inventors: Eric Mayhew, Shaukat Ali, Andrew S. Janoff