Abstract: An ingestible gastrointestinal capsule (GIC) for mechanically stimulating a segment of the gastrointestinal (GI) wall by alternately and repeatedly pressurizing, and/or vibrating it is provided. The GIC is programmed to being activated following a predefined time delay. The activated GIC agitates, shakes, rattles, jolts, vibrates and/or moves in a reciprocal expanding and contracting motion thereby mechanically stimulating the adjacent segment of the GI wall at a targeted location. Activation of the GIC may include a number of automatically accomplished partial activations, such as when the time elapsed from the moment of setting the GIC on equals a predefined time delay; when the mechanical load applied onto the GIC exceeds, and/or gets lower than a respective predefined level of mechanical load; when the ambient pH reaches a predefined level, or changes, and/or a temperature associated with the user reaches a predefined threshold. Agitation is accomplished by means of agitation means embedded in the GIC.

Abstract: A system for positioning an interchangeable tool in a body cavity includes a channel having a lumen in direct communication with the body cavity; a tool introducer having a longitudinal axis and a distal end, the tool introducer capable of traveling through the channel lumen; and a tool holder covering at least a portion of the interchangeable tool that is pivotally connected to the tool introducer allowing angular positioning of the interchangeable tool after the tool holder emerges from the channel into the body cavity. A method for engaging an interchangeable tool with a distal portion of a tool manipulator in a body cavity includes inserting a tool introducer into a channel, orienting the distal portion of the tool manipulator in the body cavity; emerging the interchangeable tool from the channel into the body cavity; and positioning the interchangeable tool eccentrically to the lumen of the channel.

Abstract: Remodeling of body tissue using a bioabsorbable implant that maintains or otherwise mechanically assists a more permanent implant or other treatment take, for example, by the treatment causing fibrosis. For example, the apparatus and methods can be used for hernia, organ prolapse and cosmetic purposes, such as breast and face lifts.

Abstract: A system for positioning an interchangeable tool in a body cavity includes a channel having a lumen in direct communication with the body cavity, a tool introducer having a longitudinal axis and a distal end, and a tool holder covering at least a portion of the interchangeable tool that is pivotally connected to the tool introducer allowing angular positioning of the interchangeable tool after the tool holder emerges from the channel into the body cavity. A method for engaging an interchangeable tool with a distal portion of a tool manipulator in a body cavity includes inserting a tool introducer into a channel, orienting the distal portion of the tool manipulator in the body cavity, emerging the interchangeable tool from the channel into the body cavity, and positioning the interchangeable tool eccentrically to the lumen of the channel.

Abstract: An ingestible gastrointestinal capsule (GIC) for mechanically stimulating a segment of the gastrointestinal (GI) wall by alternately and repeatedly pressurizing, and/or vibrating it is provided. The GIC is programmed to being activated following a predefined time delay. The activated GIC agitates, shakes, rattles, jolts, vibrates and/or moves in a reciprocal expanding and contracting motion thereby mechanically stimulating the adjacent segment of the GI wall at a targeted location. Activation of the GIC may include a number of automatically accomplished partial activations, such as when the time elapsed from the moment of setting the GIC on equals a predefined time delay; when the mechanical load applied onto the GIC exceeds, and/or gets lower than a respective predefined level of mechanical load; when the ambient pH reaches a predefined level, or changes, and/or a temperature associated with the user reaches a predefined threshold. Agitation is accomplished by means of agitation means embedded in the GIC.

Abstract: A tissue displacement/separation device includes a seamless bladder constructed of a biodegradable polymer. The bladder is expandable from a collapsed or rolled state for insertion into a body between a first and second tissue to an expanded state for separating the first and second tissue.

Abstract: A system for effecting ischemic necrosis in a foreskin of a penis includes an inner ring having an inner surface comprising an inner diameter and an outer surface comprising an outer diameter and at least one circumferential groove; and an outer ring configured to substantially fit around the circumferential groove of the inner ring, wherein the inner ring is configured to fit to a portion of a glans of the penis that lies between an inner surface of the foreskin and the glans of the penis and the at least one outer ring is configured to fit an outer surface of the foreskin, the inner ring and the outer ring thereby compressing the foreskin in the circumferential groove with a compression force, and wherein the compression force is sufficient to effect ischemic necrosis in the foreskin.

Abstract: In one embodiment, the instant invention is a method that includes at least providing a prosthesis that includes at least an implant capable of deformation under pressure; inserting the implant in a void space in a joint; inflating the implant by adding a first amount of a filler to the implant, where the first amount of the filler is X; articulating the joint; relating a second amount of the filler from the implant through a pressure regulating valve based on a predetermined pressure in the implant, where the second amount of the filler released from the implant is Y; and sealing the implant, where X is greater than Y.

Abstract: A tissue displacement/separation device is provided. The device includes a bladder which is expandable between a first tissue and a second tissue of a body. The bladder has an expanded shape which is selected capable of displacing or separating the first tissue from the second tissue in a manner suitable for protecting the first tissue from an effect of a treatment applied to the second tissue.

Abstract: A system for effecting ischemic necrosis in a foreskin of a penis includes an inner ring having an inner surface comprising an inner diameter and an outer surface comprising an outer diameter and at least one circumferential groove; and an outer ring configured to substantially fit around the circumferential groove of the inner ring, wherein the inner ring is configured to fit to a portion of a glans of the penis that lies between an inner surface of the foreskin and the glans of the penis and the at least one outer ring is configured to fit an outer surface of the foreskin, the inner ring and the outer ring thereby compressing the foreskin in the circumferential groove with a compression force, and wherein the compression force is sufficient to effect ischemic necrosis in the foreskin.

Abstract: In one embodiment, the instant invention is a method that includes at least providing a prosthesis that includes at least an implant capable of deformation under pressure; inserting the implant in a void space in a joint; inflating the implant by adding a first amount of a filler to the implant, where the first amount of the filler is X; articulating the joint; releasing a second amount of the filler from the implant through a pressure regulating valve based on a predetermined pressure in the implant, where the second amount of the filler released from the implant is Y; and sealing the implant, where X is greater than Y.

Abstract: The present disclosure provides a support element (110) for use in effecting ischemic necrosis in a foreskin of a penis, being a closed-loop member defining an opening dimensioned to permit a penis glans to pass therethrough and having an inner surface and an outer surface; the outer surface comprising a circumferential support (118) for an elastic ring (150) to be mounted thereon, said circumferential support being formed within a groove (120) in at least part of the outer surface; at least one first segment of the outer surface having an outer curvature of a radius larger than that of its flanking second segments. Also provided herein is a system (100) for effecting ischemic necrosis in a foreskin of a penis, comprising the support element (110) and elastic ring (150), and optionally a deployment element (160) for mounting the elastic ring over the foreskin and support element.

Abstract: An ingestible gastrointestinal capsule (GIC) for mechanically stimulating a segment of the gastrointestinal (GI) wall by alternately and repeatedly pressurizing, and/or vibrating it is provided. The GIC is programmed to being activated following a predefined time delay. The activated GIC agitates, shakes, rattles, jolts, vibrates and/or moves in a reciprocal expanding and contracting motion thereby mechanically stimulating the adjacent segment of the GI wall at a targeted location. Activation of the GIC may include a number of automatically accomplished partial activations, such as when the time elapsed from the moment of setting the GIC on equals a predefined time delay; when the mechanical load applied onto the GIC exceeds, and/or gets lower than a respective predefined level of mechanical load; when the ambient pH reaches a predefined level, or changes, and/or a temperature associated with the user reaches a predefined threshold. Agitation is accomplished by means of agitation means embedded in the GIC.

Abstract: The present disclosure provides a support element (110) for use in effecting ischemic necrosis in a foreskin of a penis, being a closed-loop member defining an opening dimensioned to permit a penis glans to pass therethrough and having an inner surface and an outer surface; the outer surface comprising a circumferential support (118) for an elastic ring (150) to be mounted thereon, said circumferential support being formed within a groove (120) in at least part of the outer surface; at least one first segment of the outer surface having an outer curvature of a radius larger than that of its flanking second segments. Also provided herein is a system (100) for effecting ischemic necrosis in a foreskin of a penis, comprising the support element (110) and elastic ring (150), and optionally a deployment element (160) for mounting the elastic ring over the foreskin and support element.

Abstract: A system for effecting ischemic necrosis in a foreskin of a penis includes an inner ring having an inner surface comprising an inner diameter and an outer surface comprising an outer diameter and at least one circumferential groove; and an outer ring configured to substantially fit around the circumferential groove of the inner ring, wherein the inner ring is configured to fit to a portion of a glans of the penis that lies between an inner surface of the foreskin and the glans of the penis and the at least one outer ring is configured to fit an outer surface of the foreskin, the inner ring and the outer ring thereby compressing the foreskin in the circumferential groove with a compression force, and wherein the compression force is sufficient to effect ischemic necrosis in the foreskin.

Abstract: An ingestible gastrointestinal capsule (GIC) for mechanically stimulating a segment of the gastrointestinal (GI) wall by alternately and repeatedly pressurizing, and/or vibrating it is provided. The GIC is programmed to being activated following a predefined time delay. The activated GIC agitates, shakes, rattles, jolts, vibrates and/or moves in a reciprocal expanding and contracting motion thereby mechanically stimulating the adjacent segment of the GI wall at a targeted location. Activation of the GIC may include a number of automatically accomplished partial activations, such as when the time elapsed from the moment of setting the GIC on equals a predefined time delay; when the mechanical load applied onto the GIC exceeds, and/or gets lower than a respective predefined level of mechanical load; when the ambient pH reaches a predefined level, or changes, and/or a temperature associated with the user reaches a predefined threshold. Agitation is accomplished by means of agitation means embedded in the GIC.

Abstract: System (100, 150, 200) for effecting ischemic necrosis in a foreskin of a penis, including a rigid ring (104, 158, 204), at least one elastic ring (106, 158, 206, 282, 284) and at least one circumferential groove (108), the rigid ring including an inner surface, the inner surface including an inner diameter, and an outer surface, the outer surface including an outer diameter, the elastic ring being configured to substantially fit around a surface of the rigid ring, the circumferential groove being located on a surface of at least one of the rigid ring and the elastic ring, wherein the inner diameter of the rigid ring is at least slightly larger than a diameter of a shaft of the penis, wherein a diameter of the elastic ring in a relaxed state is at least substantially equal to the diameter of the shaft of the penis, wherein the rigid ring is placed around a first surface of the foreskin, wherein the elastic ring is placed around a second surface of the foreskin, the foreskin being placed within the circumferen

Abstract: In one embodiment, the instant invention is a method that includes at least providing a prosthesis that includes at least an implant capable of deformation under pressure; inserting the implant in a void space in a joint; inflating the implant by adding a first amount of a filler to the implant, where the first amount of the filler is X; articulating the joint; releasing a second amount of the filler from the implant through a pressure regulating valve based on a predetermined pressure in the implant, where the second amount of the filler released from the implant is Y; and sealing the implant, where X is greater than Y.

Abstract: Apparatus and method for a shoulder implant, for example, for the glenohumeral joint. The implant is expandable and deflatable during implantation. The implant is sized for the glenoid fossa. In an exemplary embodiment of the invention, the selection and/or implantation of the implant include adapting the implant by size and function to a particular patient's need.

Abstract: A system for positioning an interchangeable tool in a body cavity includes a channel having a lumen in direct communication with the body cavity; a tool introducer having a longitudinal axis and a distal end, the tool introducer capable of traveling through the channel lumen; and a tool holder covering at least a portion of the interchangeable tool that is pivotally connected to the tool introducer allowing angular positioning of the interchangeable tool after the tool holder emerges from the channel into the body cavity. A method for engaging an interchangeable tool with a distal portion of a tool manipulator in a body cavity includes inserting a tool introducer into a channel, orienting the distal portion of the tool manipulator in the body cavity; emerging the interchangeable tool from the channel into the body cavity; and positioning the interchangeable tool eccentrically to the lumen of the channel.