Abstract: The present disclosure relates to the use of anti-platelet agents for the treatment of thrombosis and related conditions in a subject. The anti-platelet agent, preferably a phosphoinositide 3-kinase beta (PI3K?) inhibitor such as TGX221 or AZD6482, may be administered alone or in combination with a thrombolytic agent, preferably recombinant tissue plasminogen activator (rtPA), and/or an anticoagulant agent, preferably argatroban.

Abstract: The field of the invention relates to methods for dissolving a thrombus using inhibitors of platelet contractility. More particularly, the present invention relates to the use of an inhibitor of platelet contractility in combination with one or more thrombolytic agents and optionally one or more anticoagulants for inhibiting platelet contraction and consolidation in the developing thrombus.

Abstract: Morpholino-substituted pyridopyrimidine, quinolone, and benzopyranone derivatives inhibit phosphoinositide (PI) 3-kinase, an enzyme that regulates platelet-adhesion processes. As a consequence, the compounds in question have anti-thrombotic activity, as well as other pharmaceutical properties. The compounds claimed are represented by formula (I), (II) and (III). PI 3-kinase generates 3-phosphorylated PI second messengers which stimulate platelet adhesion under blood-flow conditions. Because platelet adhesion is a necessary step in the formation of a thrombus, inhibition by these compounds of PI 3-kinase under such conditions inhibits or prevents thrombus formation.

Abstract: The present invention relates to enantiomerically pure (?) 2-[1-(7-methyl-2-(morpholin-4-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl)ethylamino]benzoic acid or pharmaceutically acceptable salts thereof, it being in a solid state, its use in medical therapy, pharmaceutical composition comprising it, its use in the preparation of a medicament for use in a method for preventing or treating diseases, and its use in method for preventing or treating disease. The present invention relates to a selective inhibitor of phosphoinositide (PI) 3-kinase ? and use of the selective inhibitor in e.g. anti-thrombotic therapy.

Abstract: Morpholino-substituted pyridopyrimidine, quinolone, and benzopyranone derivatives inhibit phosphoinositide (PI) 3-kinase, an enzyme that regulates platelet-adhesion processes. As a consequence, the compounds in question have anti-thrombotic activity, as well as other pharmaceutical properties. The compounds claimed are represented by formula (I), (II) and (III). PI 3-kinase generates 3-phosphorylated PI second messengers which stimulate platelet adhesion under blood-flow conditions. Because platelet adhesion is a necessary step in the formation of a thrombus, inhibition by these compounds of PI 3-kinase under such conditions inhibits or prevents thrombus formation.

Abstract: Morpholino-substituted pyridopyrimidine, quinolone, and benzopyranone derivatives inhibit phosphoinositide (PI) 3-kinase, an enzyme that regulates platelet-adhesion processes. As a consequence, the compounds in question have anti-thrombotic activity, as well as other pharmaceutical properties. The compounds claimed are represented by formula (I), (II) and (III). PI 3-kinase generates 3-phosphorylated PI second messengers which stimulate platelet adhesion under blood-flow conditions. Because platelet adhesion is a necessary step in the formation of a thrombus, inhibition by these compounds of PI 3-kinase under such conditions inhibits or prevents thrombus formation.

Abstract: Morpholino-substituted pyridopyrimidine, quinolone, and benzopyranone derivatives inhibit phosphoinositide (PI) 3-kinase, an enzyme that regulates platelet-adhesion processes. As a consequence, the compounds in question have anti-thrombotic activity, as well as other pharmaceutical properties. The compounds claimed are represented by formula (I), (II) and (III). PI 3-kinase generates 3-phosphorylated PI second messengers which stimulate platelet adhesion under blood-flow conditions. Because platelet adhesion is a necessary step in the formation of a thrombus, inhibition by these compounds of PI 3-kinase under such conditions inhibits or prevents thrombus formation.

Abstract: A convenient configuration for determining the presence of a wireless network includes an electronic network detector device supported either on the carrying case for a portable electronic device or the device itself, be it a laptop or hand-held computer, smart phone, or portable digital assistant. In the preferred embodiment, the electronic network detector device is supported on, or integrally formed with, the computer case. The detector may be disposed on a handle, shoulder strap, or other location providing convenient access. The network detector may detect a Wi-Fi network or other wireless infrastructure, and may show the signal strength of the network and/or the direction in which the signal strength of the network is the strongest.

Abstract: A case configured to enclose a portable electronic device includes a plurality of externally accessible electrical contacts, enabling electrical current to flow to or from the device while enclosed in the case. The invention is applicable to all types of portable devices, including laptop, notebook and palm-top computers, as well as telecommunications devices, video players and music players. Typically the electrical contacts allow a battery in the case or in the device to be recharged while device is enclosed. An adaptor cable may be provided between the device and the electrical contacts so that the same or similar case may be used with different model devices from different manufacturers. For greater ‘universality,’ a voltage-changing adaptor cable may be provided within the case between the device and the electrical contacts. The system may further include a docking bay to receive the case, the docking bay having a set of electrical contacts configured to electrically engage with the contacts on the case.

Abstract: The present invention relates to selective inhibitors of phosphoinositide (PI) 3-kinase ?, use of the selective inhibitors in anti-thrombotic therapy, and a method for screening compounds useful for the new anti-thrombotic therapy by detecting selective inhibitory activity of PI 3-kinase ? of the compound. The invention also relates to novel compounds that are inhibitors of PI 3-kinase.

Abstract: Morpholino-substituted pyridopyrimidine, quinolone, and benzopyranone derivatives inhibit phosphoinositide (PI) 3-kinase, an enzyme that regulates platelet-adhesion processes. As a consequence, the compounds in question have anti-thrombotic activity, as well as other pharmaceutical properties. The compounds claimed are represented by formula (I), (II) and (III). PI 3-kinase generates 3-phosphorylated PI second messengers which stimulate platelet adhesion under blood-flow conditions. Because platelet adhesion is a necessary step in the formation of a thrombus, inhibition by these compounds of PI 3-kinase under such conditions inhibits or prevents thrombus formation.

Abstract: Morpholino-substituted pyridopyrimidine, quinolone, and benzopyranone derivatives inhibit phosphoinositide (PI) 3-kinase, an enzyme that regulates platelet-adhesion processes. As a consequence, the compounds in question have anti-thrombotic activity, as well as other pharmaceutical properties. The compounds claimed are represented by formula (I), (II) and (III). PI 3-kinase generates 3-phosphorylated PI second messengers which stimulate platelet adhesion under blood-flow conditions. Because platelet adhesion is a necessary step in the formation of a thrombus, inhibition by these compounds of PI 3-kinase under such conditions inhibits or prevents thrombus formation.

Abstract: Disclosed is a carbon dioxide absorbent formulation comprising: a pharmaceutically acceptable hydroxide essentially free of sodium, potassium and barium hydroxides; calcium and/or magnesium chloride; a hardening agent; and a non-film-forming binding agent.

Abstract: Morpholino-substituted pyridopyrimidine, quinolone, and benzopyranone derivatives inhibit phosphoinositide (PI) 3-kinase, an enzyme that regulates platelet-adhesion processes. As a consequence, the compounds in question have anti-thrombotic activity, as well as other pharmaceutical properties. The compounds claimed are represented by formula (I), (II) and (III). PI 3-kinase generates 3-phosphorylated PI second messengers which stimulate platelet adhesion under blood-flow conditions. Because platelet adhesion is a necessary step in the formation of a thrombus, inhibition by these compounds of PI 3-kinase under such conditions inhibits or prevents thrombus formation.

Abstract: An article for use with a laptop computing device protects the device during periods of non-use, including transport, while stabilizing the device when positioned on a user's lap. The article provides a base panel having front, rear and two side sections, a lower surface adapted to rest on a user's lap, and an upper surface to receive the bottom surface of the laptop device. The preferred embodiment includes two side panels, each with a storage compartment, which may be dressed over the user's thighs to assist in stabilizing the laptop device during use. Attachment means are preferably provided for securing the side panels to one another across the top surface of the computing device during periods of non-use or transport. Preferably flexible front and rear panels may also be folded over and onto the top surface of the computer in overlapping fashion beneath the secured side panels to create a protective device wrapper in conjunction with surrounding closure means and a carrying handle.

Abstract: An article for use with a laptop computing device protects the device during periods of non-use, including transport, while stabilizing the device when positioned on a user's lap. The article provides a base panel having front, rear and two side sections, a lower surface adapted to rest on a user's lap, and an upper surface to receive the bottom surface of the laptop device. The preferred embodiment includes two side panels, each with a storage compartment, which may be dressed over the user's thighs to assist in stabilizing the laptop device during use. Attachment means are preferably provided for securing the side panels to one another across the top surface of the computing device during periods of non-use or transport. Preferably flexible front and rear panels may also be folded over and onto the top surface of the computer in overlapping fashion beneath the secured side panels to create a protective device wrapper in conjunction with surrounding closure means and a carrying handle.

Abstract: An anthropomorphic travel system includes a fillable module, the shape of which approximates the upper shoulder area of a human torso, enabling a coat or like garment to be carried over and along with the module so as to minimize wrinkling of the garment. In the preferred embodiment this module is multi-compartmentalized, and includes a bottom portion with a pair of spaced-apart hooks which extend downwardly therefrom, the hooks being adapted to releasably grasp the bottom member of a clothes hanger to carry a garment secured thereto. The module also includes a back surface from which there extends downwardly a flexible, compartmentalized panel such that even when the module and panel with overdraping garment(s) are covered with an outer bag, the entire system may be folded in half lengthwise and secured in that state for compact transport while continuing to minimize wrinkling of the garment(s).

Abstract: An exercise device intended to provide effective exercise for all major muscle groups of the human body. The device employs a bicycle wind trainer to provide lower body exercise, a rowing machine utilizing the rear wheel of the bicycle to provide upper body exercise, a bench press assembly to provide further upper body exercise, and a cable and weight assembly to provide further upper body exercise when used in conjunction with the bench.

Abstract: A pannier for a cycle adapted to be secured to a carrier rack mounted over a wheel. A flexible, generally rectangular bag is of sufficient size that its rear portion extends downwardly from the carrier closely adjacent to the spokes of the wheel. A rigid panel fixed to the rear of the bag and extending substantially to the bottom of the bag is utilized to provide structural definition for the bag and to prevent it from interfering with the spokes. A U-shaped bar having opposed ends pivotally connected to the rear panel is employed for holding the bag in an open or collapsed condition. In one embodiment a second panel extends substantially across the bottom of the bag and is pivotally connected to the lower edge of the first panel to provide lateral stability for the bag. The opposed ends of the bar may be utilized as pivot pins for both the panels and the bar.

Abstract: In one embodiment the saddlebag includes a cutaway in the forward lower corner portion thereof to provide a heel clearance for a passenger on the cycle. A substantially solid panel is affixed to the interior rear of the bag and an elongated attachment plate is provided on the exterior rear of the saddlebag. A U-shaped bar pivotally mounted to the interior panel is advantageously employed as part of the internal frame construction for the bag. The bags are mounted on the cycle by way of a first pair of straps secured to spaced locations on the seat and a second pair of straps removably connected thereto. The ends of the straps of the second pair are detachably secured to the attachment plate on the saddlebags. A rigid strap mounted to a fixed part of the cycle is adapted to receive a connector extending from the lower front side of the saddlebag. A rear strap connecting the rear portions of a pair of saddlebags is also provided. Each saddlebag may include detachable exhaust/abrasion shields.