Abstract: A system and a method of growing shrimp, allowing balanced processes to accomplish the intensive culture of shrimp while reducing the risk of loss due to disease or environmental contaminants. Specifically, the present invention involves a unique combination of elements including: the use of specific pathogen free marine animal stocks, facilities which are effectively disinfected and isolated from sources of disease vectors and environmental contaminants, a beneficial, synergistic microbial population, and an aqueous medium of controlled composition. The system also comprises a specialized feed for supporting the microorganisms and marine animals, with zero-exchange of aqueous medium throughout the growout cycle such that the solids formed during operation, uneaten feeds, and fecal matter are retained in the system to provide an environment suitable for high yields and growth rates of marine animals.