Patents by Inventor Shaun Stauffer

Shaun Stauffer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • O-BENZYL NICOTINAMIDE ANALOGS AS MGLUR5 POSITIVE ALLOSTERIC MODULATORS
    Publication number: 20110183980
    Abstract: In one aspect, the invention relates to O-benzyl nicotinamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: September 21, 2010
    Publication date: July 28, 2011
    Inventors: P. Jeffrey Conn, Craig W. Lindsley, Charles David Weaver, Shaun Stauffer, Richard Williams, Gregor MacDonald, Ya Zhou, José Manuel Bartolomé-Nebreda
  • 2,4,6-Substituted Pyridyl Derivative Compounds Useful as Beta-Secretase Inhibitors for the Treatment of Alzheimer's Disease
    Publication number: 20080015233
    Abstract: The present invention is directed to 2,4,6-substituted pyridyl derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
    Type: Application
    Filed: April 20, 2005
    Publication date: January 17, 2008
    Inventors: James Barrow, Georgia McGaughey, Philippe Nantermet, Hemaka Rajapakse, Harold Selnick, Shaun Stauffer, Joseph Vacca, Shawn Stachel, Craig Coburn, Matthew Stanton
  • 2,3,4,6-Substituted Pyridyl Derivative Compounds Useful As Beta-Secretase Inhibitors For The Treatment Of Alzheimer's Disease
    Publication number: 20070293497
    Abstract: The present invention is directed to 2,3,4,6-substituted pyridyl derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
    Type: Application
    Filed: November 18, 2005
    Publication date: December 20, 2007
    Inventors: Philippe Nantermet, Hemaka Rajapakse, Harold Selnick, James Barrow, Shaun Stauffer, Joseph Vacca, Keith Moore, Shawn Stachel, Mattahew Stanton
  • 1,3,5-Substituted Phenyl Derivative Compounds Useful as Beta-Secretase Inhibitors for the Treatment of Alzheimer's Disease
    Publication number: 20070244119
    Abstract: The present invention is directed to 1,3,5-phenyl substituted derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
    Type: Application
    Filed: April 15, 2005
    Publication date: October 18, 2007
    Inventors: James Barrow, Georgia McGaughey, Philippe Nantermet, Hemaka Rajapakse, Harold Selnick, Shaun Stauffer, Craig Coburn
  • Spiropiperidine compounds useful as beta-secretase inhibitors for the treatment of alzheimer' s disease
    Publication number: 20070197571
    Abstract: The present invention is directed to spiropiperidine compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
    Type: Application
    Filed: October 12, 2005
    Publication date: August 23, 2007
    Inventors: James Barrow, Craig Coburn, Melissa Egbertson, Georgia McGaughey, Melody McWherter, Lou Neilson, Kenneth Rittle, Harold Selnick, Shaun Stauffer, Zhi-Qiang Yang, Wenjin Yang, Wanli Lu, Bruce Fahr
  • Phenylamide and pyridylamide beta-secretase inhibitors for the treatment of alzheimer's disease
    Publication number: 20070142634
    Abstract: The present invention is directed to phenylamide and pyridylamide derivative compounds of which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
    Type: Application
    Filed: December 15, 2004
    Publication date: June 21, 2007
    Inventors: James Barrow, Craig Coburn, Philippe Nantermet, Harold Selnick, Shawn Stachel, Matthew Stanton, Shaun Stauffer, Linghang Zhuang, Jennifer Davis
  • Benzylether and benzylamino beta-secretase inhibitors for the treatment of alzheimer's disease
    Publication number: 20070088165
    Abstract: The present invention is directed to benzylether and benzylamino derivative compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
    Type: Application
    Filed: November 19, 2004
    Publication date: April 19, 2007
    Inventors: Philippe Nantermet, Hemaka Rajapakse, Harold Selnick, Shaun Stauffer, Mary Beth Young
  • Spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease
    Publication number: 20070021454
    Abstract: The present invention is directed to spiropiperidine compounds of formula (I) and tautomers thereof, which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
    Type: Application
    Filed: July 14, 2006
    Publication date: January 25, 2007
    Inventors: Craig Coburn, Melissa Egbertson, Samuel Graham, Georgia McGaughey, Shaun Stauffer, Hemaka Rajapakse, Philippe Nantermet, Shawn Stachel, Wenjin Yang, Wanli Lu, Bruce Fahr
  • Sterically hindered phosphine ligands and uses thereof
    Publication number: 20020165411
    Abstract: The present invention is directed to a catalyst composition, comprising a Group 8 metal; and a ligand having a structure selected from the group consisting of: 1
    Type: Application
    Filed: December 10, 2001
    Publication date: November 7, 2002
    Inventors: John F. Hartwig, James Stambuli, Shaun Stauffer