Abstract: Disclosed herein are compositions, methods, and systems for treating skin damage or signs of aging in a subject including obtaining whole blood from the subject, collecting platelet rich plasma (PRP) from the whole blood, forming a first topical formulation having the PRP, providing the first topical formulation to the subject for application to an area of skin damage on the subject, providing a second topical formulation to the subject having an activator such that when the second topical formulation is applied to the area of skin damage on top of the first formulation, the PRP is activated and growth factors are released into the area of skin damage. Systems and kits useful in performing the methods are also disclosed.

Abstract: A plasma fractionation device having a removable cartridge connected to a handpiece where the removable cartridge includes a plurality of channels or magnetic poles that are filled with an inert gas that can be activated to produce plasma which exits the cartridge through the plurality of channels or magnetic poles. The plasma exiting through the plurality of channels or magnetic poles simultaneously creates a plurality of epidermal wounds.

Abstract: Disclosed herein are compositions, methods, and systems for treating skin damage or signs of aging in a subject including obtaining whole blood from the subject, collecting platelet rich plasma (PRP) from the whole blood, forming a first topical formulation having the PRP, providing the first topical formulation to the subject for application to an area of skin damage on the subject, providing a second topical formulation to the subject having an activator such that when the second topical formulation is applied to the area of skin damage on top of the first formulation, the PRP is activated and growth factors are released into the area of skin damage. Systems and kits useful in performing the methods are also disclosed.

Abstract: A system and apparatus for separating biological tissue and/or biological fluids and in particular a system and apparatus for separating whole blood in order to obtain plasma or platelet-rich plasma which includes embodiments of separation vessels that are rotated about a vertical axis. Some separation vessels include both a separation chamber and a collection chamber. The invention also includes a system and apparatus for mixing biological tissue and/or biological fluids with other materials to create pharmaceutical grade injectables.

Abstract: A microneedling system may reciprocate a plurality of microneedles disposed on a handpiece into the skin of a patient. The microneedles and/or electrode plates may deliver RF energy to the patient for inducing collagen coagulation and regeneration. An interrogative modality such as ultrasound may combined into the microneedling handpiece or used as a separate instrument to interrogate the skin and identify or measure the thicknesses of constituent layers. The data obtained from the interrogative modality may be displayed and can be used to automatically adjust operating parameters of the microneedling device, including the penetration depth of the needles, the pulse duration, and/or the power level of the RF energy to optimize the treatment for the specific patient and/or condition being treated. The microneedling system may recall the skin measurements for distinct sectors of the skin which are expected to have different properties.

Abstract: A microneedling system may reciprocate a plurality of microneedles disposed on a handpiece into the skin of a patient. The handpiece may have a plurality of positive and negative electrodes in the form of microneedles or surface electrodes arranged across an array. The microneedles and/or electrode plates may deliver RF energy to the patient for inducing collagen coagulation and regeneration. The electrodes may be arranged such that each electrode is positioned adjacent a closest electrode of opposite polarity. There may be an uneven number of positive and negative electrodes. Central electrodes may be surrounded by at least three adjacent closest electrodes of opposite polarity. The electrodes may be arranged in a hexagonal or other polygonal manner. The electrodes may be arranged to provide uniform distribution of energy, heating, and effectively to some extent damage the entire discrete area that encloses the positive and negative electrodes.

Abstract: A microneedling system may reciprocate a plurality of microneedles disposed on a handpiece into the skin of a patient. The microneedles and/or electrode plates may deliver RF energy to the patient for inducing collagen coagulation and regeneration. An interrogative modality such as ultrasound may combined into the microneedling handpiece or used as a separate instrument to interrogate the skin and identify or measure the thicknesses of constituent layers. The data obtained from the interrogative modality may be displayed and can be used to automatically adjust operating parameters of the microneedling device, including the penetration depth of the needles, the pulse duration, and/or the power level of the RF energy to optimize the treatment for the specific patient and/or condition being treated. The microneedling system may recall the skin measurements for distinct sectors of the skin which are expected to have different properties.

Abstract: Disclosed herein are compositions, methods, and systems for treating skin damage or signs of aging in a subject including obtaining whole blood from the subject, collecting platelet rich plasma (PRP) from the whole blood, forming a first topical formulation having the PRP, providing the first topical formulation to the subject for application to an area of skin damage on the subject, providing a second topical formulation to the subject having an activator such that when the second topical formulation is applied to the area of skin damage on top of the first formulation, the PRP is activated and growth factors are released into the area of skin damage. Systems and kits useful in performing the methods are also disclosed.

Abstract: A microneedling system may reciprocate a plurality of microneedles disposed on a handpiece into the skin of a patient. The microneedles and/or electrode plates may deliver RF energy to the patient for inducing collagen coagulation and regeneration. An interrogative modality such as ultrasound may combined into the microneedling handpiece or used as a separate instrument to interrogate the skin and identify or measure the thicknesses of constituent layers. The data obtained from the interrogative modality may be displayed and can be used to automatically adjust operating parameters of the microneedling device, including the penetration depth of the needles, the pulse duration, and/or the power level of the RF energy to optimize the treatment for the specific patient and/or condition being treated. The microneedling system may recall the skin measurements for distinct sectors of the skin which are expected to have different properties.

Abstract: Disclosed herein are compositions, methods, and systems for treating skin damage or signs of aging in a subject including obtaining whole blood from the subject, collecting platelet rich plasma (PRP) from the whole blood, forming a first topical formulation having the PRP, providing the first topical formulation to the subject for application to an area of skin damage on the subject, providing a second topical formulation to the subject having an activator such that when the second topical formulation is applied to the area of skin damage on top of the first formulation, the PRP is activated and growth factors are released into the area of skin damage. Systems and kits useful in performing the methods are also disclosed.

Abstract: Disclosed herein are compositions, methods, and systems for treating skin damage or signs of aging in a subject including obtaining whole blood from the subject, collecting platelet rich plasma (PRP) from the whole blood, forming a first topical formulation having the PRP, providing the first topical formulation to the subject for application to an area of skin damage on the subject, providing a second topical formulation to the subject having an activator such that when the second topical formulation is applied to the area of skin damage on top of the first formulation, the PRP is activated and growth factors are released into the area of skin damage. Systems and kits useful in performing the methods are also disclosed.

Abstract: Disclosed herein are compositions, methods, and systems for treating skin damage or signs of aging in a subject including obtaining whole blood from the subject, collecting platelet rich plasma (PRP) from the whole blood, forming a first topical formulation having the PRP, providing the first topical formulation to the subject for application to an area of skin damage on the subject, providing a second topical formulation to the subject having an activator such that when the second topical formulation is applied to the area of skin damage on top of the first formulation, the PRP is activated and growth factors are released into the area of skin damage. Systems and kits useful in performing the methods are also disclosed.