Patents by Inventor Shaw-guang Lee

Shaw-guang Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for isolation of antigen specific immunoglobulin
    Patent number: 4806346
    Abstract: A process for preparing the purified F(ab).sub.2 fragment of equine Ig(T) from horses hyperimmunized with snake venom which comprises:(a) passing crude diluted hyperimmune equine serum contianing snake venom antigen specific Ig(T) buffered to an acidic pH through a strong base anion exchange polymer;(b) passing the resultant pass-through solution to which is added sodium chloride to a concentration of 0.05-0.124M through a strong acid cation exchange polymer;(c) adjusting the pH of the pass-through of step (b) to a pH of 3.3, and digesting said pass-through with pepsin; and(d) ultrafiltering said pepsin-digested pass-through to obtain purified F(ab).sub.2 fragment of the snake venom antigen specific equine Ig(T).
    Type: Grant
    Filed: December 16, 1986
    Date of Patent: February 21, 1989
    Assignee: American Home Products Corporation
    Inventors: Wah-tung Hum, Shaw-guang Lee
  • Recombinant deoxyribonucleic acid which codes for plasminogen activator and method of making plasminogen activator protein therefrom
    Patent number: 4558010
    Abstract: The present invention provides a deoxyribonucleic acid (DNA) segment related to a human plasminogen activator gene. The segment is inserted into a plasmid vector which in turn can be incorporated into a bacterium or other microorganism. The bacterium can then be cultured to produce a plasminogen activator protein having properties of human urokinase.
    Type: Grant
    Filed: September 7, 1982
    Date of Patent: December 10, 1985
    Assignee: Abbott Laboratories
    Inventors: Paul P. Hung, Shaw-Guang Lee, Ranajit Roychoudhury, Barry J. Ratzkin
  • Recombinant deoxyribonucleic acid which codes for plasminogen activator
    Patent number: 4370417
    Abstract: The present invention provides a deoxyribonucleic acid (DNA) segment related to a human plasminogen activator gene. The segment is inserted into a plasmid vector which in turn can be incorporated into a bacterium or other microorganism. The bacterium can then be cultured to produce a plasminogen activator protein having properties of human urokinase.
    Type: Grant
    Filed: April 3, 1980
    Date of Patent: January 25, 1983
    Assignee: Abbott Laboratories
    Inventors: Paul P. Hung, Shaw-Guang Lee, Ranajit Roychoudhury, Barry J. Ratzkin, W. Jurgen Schrenk, Michael C. Chen
  • Deoxyribonucleic acid synthesis using binding protein extracted from chick embryo fibroblasts
    Patent number: 4331589
    Abstract: Described is a method of obtaining complete copying of the entire length of single stranded ribonucleic acid (RNA) into its complementary deoxyribonucleic acid (cDNA) by reverse transcription using binding protein. The method can be used in recombinant DNA research to copy total messenger RNA into DNA.
    Type: Grant
    Filed: April 16, 1981
    Date of Patent: May 25, 1982
    Assignee: Abbott Laboratories
    Inventors: Paul P. Hung, Shaw-Guang Lee
  • Modified urokinase having extended activity and method of making
    Patent number: 4326033
    Abstract: Described is a structurally modified urokinase which is biologically active over an extended time period in comparison to native urokinase. The extended activity permits the administration of lower doses of urokinase when it is used in the treatment of thromboembolic diseases. Methods of appropriately modifying the structure of urokinase are described.
    Type: Grant
    Filed: May 5, 1980
    Date of Patent: April 20, 1982
    Assignee: Abbott Laboratories
    Inventors: William H. Holleman, Shaw-Guang Lee, Paul P. Hung
  • Deoxyribonucleic acid synthesis using binding protein
    Patent number: 4224408
    Abstract: Described is a method of obtaining complete copying of the entire length of single stranded ribonucleic acid (RNA) into its complementary deoxyribonucleic acid (cDNA) by reverse transcription using binding protein. The method can be used in recombinant DNA research to copy total messenger RNA into DNA.
    Type: Grant
    Filed: November 22, 1978
    Date of Patent: September 23, 1980
    Assignee: Abbott Laboratories
    Inventors: Paul P. Hung, Shaw-guang Lee