Abstract: The present disclosure provides a method of detecting a joint disease, the method comprising administering a composition comprising an agent chosen from LS301, LS838, or a derivative thereof to a subject in need thereof; and detecting a signal intensity emitted from the agent in at least one joint of the subject, wherein detection of signal intensity above a baseline value indicates the subject has the joint disease. Also are provided are methods for monitoring the progression of a joint disease, monitoring treatment response to a therapeutic agent for treating a joint disease, and treating a joint disease.