Abstract: Provided herein are surgical implants and methods of manufacturing the implants. The implants are generally osteoconductive composite implants utilizing minimally-crosslinked acrylic carriers combined with osteoconductive ceramics. The methods generally involve dissolving a monomer and an initiator in a solvent to form a reaction mixture, controlling the temperature and viscosity of the reaction mixture to allow solution polymerization, polymerizing the monomer in the reaction mixture to form an acrylic carrier, recovering the acrylic carrier, extruding the acrylic carrier with an osteoconductive ceramic to form an osteoconductive biomaterial, and processing the osteoconductive biomaterial to form the osteoconductive composite implant.

Abstract: Provided herein are surgical implants and methods of manufacturing the implants. The surgical implant includes an outer body made of a polymer, at least one internal strut coupled to the outer body, where the internal strut has a smaller diameter than the outer body, and ceramic granules deposited on the surface of the internal strut. Methods of manufacturing a surgical implant generally include injecting a molten mixture containing a polymer and ceramic particles into a mold. The mold defines a negative space for forming the implant. As the molten mixture flows through the negative space, the mold constricts the flow at the internal strut, causing the ceramic granules to deposit on the surface of the internal strut. The mixture is then cooled to form the implant, with the ceramic granules at least partially exposed on its surface.

Abstract: A method of generating a bioceramic-containing biomaterial-derived thermoplastic extrusion is provided. The method includes combining a bioceramic-containing solid with at least one thermoplastic resin, wherein the bioceramic-containing solid is uniformly dispersed in the resin. The method further includes extruding the bioceramic-containing solid included in the resin to create a net shape. The net shape is selected from a group consisting of a filament, a pellet, a bar, a molding, and a three-dimensional printing material stock.

Abstract: A method of preparing a reconstitutable implantable bone putty includes combining a bone matrix derived from human bone and gelatin particulates derived from human tissue at a concentration of the bone matrix by dry weight of 20 to 60 percent to form the reconstitutable implantable bone putty. Preparing the gelatin particulates includes supplying a gelatin precursor of bone or soft tissue from a human, treating the gelatin precursor with phosphoric acid to generate a gelatin-acid mixture, neutralizing the gelatin-acid mixture with an alkali to a pH between 6 and 8 to allow a gelatin-rich solution and a waste solution to separate, removing residual salts from the gelatin-rich solution to obtain purified gelatin, drying the purified gelatin, and reducing the purified gelatin to particulates having a largest dimension less than 300 ?m. A method of preparing an implantable bone putty includes adding a reconstitution media to the reconstitutable implantable bone putty.

Abstract: A system, device/implant, method and processes for manufacturing a filament and an implant having at least one or a plurality of areas in the implant comprised of selectively-place bone to facilitate osteoconductivity and, potentially, osteoinductivity after the implant is implanted into a patient.

Abstract: A method of preparing a reconstitutable implantable bone putty includes combining a bone matrix derived from human bone and gelatin particulates derived from human tissue at a concentration of the bone matrix by dry weight of 20 to 60 percent to form the reconstitutable implantable bone putty. Preparing the gelatin particulates includes supplying a gelatin precursor of bone or soft tissue from a human, treating the gelatin precursor with phosphoric acid to generate a gelatin-acid mixture, neutralizing the gelatin-acid mixture with an alkali to a pH between 6 and 8 to allow a gelatin-rich solution and a waste solution to separate, removing residual salts from the gelatin-rich solution to obtain purified gelatin, drying the purified gelatin, and reducing the purified gelatin to particulates having a largest dimension less than 300 ?m. A method of preparing an implantable bone putty includes adding a reconstitution media to the reconstitutable implantable bone putty.

Abstract: The present disclosure includes devices, apparatuses, and methods for forming lyophilized soft-tissue allografts for the correction of skeletal impairments (e.g., misalignments, arthritis, etc.), and soft-tissue allograft implants formed from the same.

Abstract: Various embodiments describe methods of predicting an amount of a target osteoactivity marker. The methods include measuring an initial concentration of the target osteoactivity marker at a time t0; measuring an initial concentration of at least one additional osteoactivity marker at the time t0; and calculating a second concentration of the target osteoactivity marker at a time t1 based on the initial concentration of the target osteoactivity marker at the time t0 and the initial concentration of the at least one additional osteoactivity marker at the time t0.

Abstract: According to various embodiments, a bone product includes bone having at least one patterned surface. The patterned surface includes a plurality of pits. Each of the plurality of pits has a diameter of from about 5 ?m to about 15 ?m and a depth of approximately half of the diameter.