Abstract: A biocompatible structure includes a scaffold obtained from a 3D structure. The 3D structure includes base layered structures, each of which includes at least a first layer and a second layer surrounded by the first layer. The first layer includes at least one of first, second and third media. The second layer includes at least another of the first, second and third media. The first medium comprises bone particles. The second medium comprises a polymer dissolvable in a first solvent. The third medium comprises solid particulates dissolvable in a second solvent different than the first solvent. The 3D structure is treated with the second solvent to dissolve the solid particulates so as to form pores at positions of the solid particulates therein, thereby resulting in the scaffold having a porosity adjustable by sizes of the solid particulates and concentration of the solid particulates in the 3D structure.

Abstract: The disclosure relates to a scaffold for tissue regeneration and methods for fabricating the scaffold. The scaffold includes a three-dimensional structure composed by alternating layers of various materials including a first medium, a second medium and a third medium. The first medium includes bone particles each having a size of 1 nm to 100 mm with or without organic components. The second medium is a natural or synthetic biocompatible and/or biodegradable polymer. The third medium is a material dissolved in a solvent different than the solvent of the polymer and includes solid particulates alone or in polymeric structures that dissolve when immersed in liquid or gaseous solvent environments or based on temperature differentials. The various materials are arranged according to the shape and the size of a bone gap being generated. The three-dimensional structure has a tunable porosity with interconnected channels and pores along with adjustable dimensions.

Abstract: The disclosure relates to a scaffold useable for tissue regeneration and methods for fabricating the scaffold. The scaffold includes a three-dimensional structure having a tunable porosity with interconnected channels and pores along with adjustable dimensions, and being formed of at least one of a first medium, a second medium, a third medium and a fourth medium. The first medium comprises one or more polymers that are biocompatible and biodegradable. The second medium comprises one or more soluble materials, and is mixable with the first medium. The third medium comprises fillers of one or more insoluble materials having structures with dimensions between 1 nm to 5 mm, and is mixable in a bulk or surface of the first medium or the second medium individually, or in a bulk or surface of a combination of the first and second media. The fourth medium comprises an agent.