Patents by Inventor Shawn Edward Lupold

Shawn Edward Lupold has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for retargeting virus constructs
    Patent number: 9458473
    Abstract: The present invention relates to the field of viral gene therapy. More specifically, the present invention provides compositions and methods for retargeting virus constructs. In one embodiment, the present invention provides an adenoviral construct comprising a nucleic acid encoding the peptide sequence MAE-X-PDP (SEQ ID NO:45), wherein X is an antigen targeting peptide. In a more specific embodiment, an adenoviral construct comprises a nucleic acid sequence encoding the peptide sequence MAEWQPDTAHHWALTLPDP (SEQ ID NO:10) inserted into the HI-loop of adenovirus fiber protein.
    Type: Grant
    Filed: June 29, 2011
    Date of Patent: October 4, 2016
    Assignee: The Johns Hopkins University
    Inventors: Shawn Edward Lupold, Ping Wu, Ronald Rodriguez
  • Radiation sensitization agents for prostate cancer
    Patent number: 9029340
    Abstract: Compositions and methods are provided for sensitizing neoplastic cells to radiotherapy. The invention provides aptamer-inhibitory nucleic acid chimeras that selectively inliibit the expression of radiosensitizing genes in neoplastic cells expressing a cell surface molecule that binds the aptamer.
    Type: Grant
    Filed: July 22, 2011
    Date of Patent: May 12, 2015
    Assignee: The Johns Hopkins University
    Inventors: Shawn Edward Lupold, Theodore L. DeWeese, Xiaohua Ni, Yonggang Zhang
  • COMPOSITIONS AND METHODS FOR DETECTING AND QUANTIFYING CIRCULATING TUMOR CELLS (CTCs)
    Publication number: 20140017668
    Abstract: The present invention relates to the field of virology. More specifically, the present invention relates to the use of viral constructs to detect and quantify circulating tumor cells. In one embodiment, the present invention provides an adenovirus construct comprising (a) a cell type specific promoter that drives adenoviral replication; and (b) at least one reporter gene incorporated into the viral Major Late Transcriptional Unit. In another embodiment, an adenovirus construct comprises (a) prostate selective pro-basin promoter operably linked to the El gene; and (b) prostate specific antigen enhancer operably linked to the probasin promoter.
    Type: Application
    Filed: June 30, 2011
    Publication date: January 16, 2014
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Shawn Edward Lupold, Wasim Haider Chowdhury, Ping Wu, Ronald Rodriguez
  • COMPOSITIONS AND METHODS FOR RETARGETING VIRUS CONSTRUCTS
    Publication number: 20130315870
    Abstract: The present invention relates to the field of viral gene therapy. More specifically, A the present invention provides compositions and methods for retargeting virus constructs. In one embodiment, the present invention provides an adenoviral construct comprising a nucleic acid encoding the peptide sequence MAE-X-PDP, wherein X is an antigen targeting peptide. In a more specific embodiment, an adenoviral construct comprises a nucleic acid sequence encoding the peptide sequence MAEWQPDTAHHWALTLPDP inserted into the HI-loop of adenovirus fiber protein.
    Type: Application
    Filed: June 29, 2011
    Publication date: November 28, 2013
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Shawn Edward Lupold, Ping Wu, Ronald Rodriguez
  • RADIATION SENSITIZATION AGENTS FOR PROSTATE CANCER
    Publication number: 20130123566
    Abstract: Compositions and methods are provided for sensitizing neoplastic cells to radiotherapy. The invention provides aptamer-inhibitory nucleic acid chimeras that selectively inliibit the expression of radiosensitizing genes in neoplastic cells expressing a cell surface molecule that binds the aptamer.
    Type: Application
    Filed: July 22, 2011
    Publication date: May 16, 2013
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Shawn Edward Lupold, Theodore L. DeWeese, Xiaohua Ni, Yonggang Zhang
  • Adenoviral fiber exchange shuttle system
    Patent number: 8088621
    Abstract: The instant invention provides methods and compositions for generating recombinant adenoviral vectors. The invention also provides kits comprising for the generation of recombinant adenoviral vectors.
    Type: Grant
    Filed: September 14, 2007
    Date of Patent: January 3, 2012
    Assignee: The Johns Hopkins University
    Inventors: Ronald Rodriguez, Shawn Edward Lupold, Wasim Haider Chowdhury, Tarana A. Kudrolli