Abstract: Systems and methods for transaction/file-based management of a plurality of processes associated with various jobs are provided. Through the management of discrete applications, a file distribution manager/scheduler orchestrates automated execution of different types of jobs. The processes executed for the various processes can vary based on job type, or other parameters.

Abstract: An apparatus includes a medicament container assembly, a movable assembly, and a spring. The medicament container assembly includes a first plunger defining a first volume, and a second plunger defining a second volume. The movable assembly includes a first movable member and a second movable member. The second movable member can move the second plunger within the medicament container assembly. The first movable member can move the first plunger in a first direction within the medicament container assembly to expel contents of at least the first volume via a needle. The spring is configured to urge the needle in a second direction. The release portion of the first movable member is configured to contact the second movable member after the first movable member moves the first plunger to enable the spring to move the needle in the second direction.

Abstract: A computing device executes one or more trusted execution environment (TEE) processes in a TEE of a processor. The one or more TEE processes cryptographically protect a secret and a policy. The policy specifies a plurality of conditions on usage of the secret. A particular non-TEE process generates a request whose fulfillment involves an action requiring use of the secret. Responsive to the request, one or more non-TEE processes determine whether a first subset of the plurality of conditions is satisfied. Responsive to the first subset of the plurality of conditions being satisfied, the one or more TEE processes determine that a second, different subset of the plurality of conditions is satisfied. Responsive to determining the second subset of the plurality of conditions is satisfied, the one or more TEE processes use the secret to perform the action.

Abstract: According to computerized methods of distributing software and data, software components may be distributed electronically for execution in controlled environments. Such a controlled environment may, for example, restrict the components' ability to communicate through a network to one or more specified hosts. When a component requests data, such as a stream of financial data, the request may specify a source of the data, and the request may be granted or denied by the distributor based on whether the specified source is an authorized source of the data and/or whether the requested data is available from an authorized source.

Abstract: Systems and methods for transaction/file-based management of a plurality of processes associated with various jobs are provided. Through the management of discrete applications, a file distribution manager/scheduler orchestrates automated execution of different types of jobs. The processes executed for the various processes can vary based on job type, or other parameters.

Abstract: A computing device executes one or more trusted execution environment (TEE) processes in a TEE of a processor. The one or more TEE processes cryptographically protect a secret and a policy. The policy specifies a plurality of conditions on usage of the secret. A particular non-TEE process generates a request whose fulfillment involves an action requiring use of the secret. Responsive to the request, one or more non-TEE processes determine whether a first subset of the plurality of conditions is satisfied. Responsive to the first subset of the plurality of conditions being satisfied, the one or more TEE processes determine that a second, different subset of the plurality of conditions is satisfied. Responsive to determining the second subset of the plurality of conditions is satisfied, the one or more TEE processes use the secret to perform the action.

Abstract: The present invention relates to the field of viral gene therapy. More specifically, the present invention provides compositions and methods for retargeting virus constructs. In one embodiment, the present invention provides an adenoviral construct comprising a nucleic acid encoding the peptide sequence MAE-X-PDP (SEQ ID NO:45), wherein X is an antigen targeting peptide. In a more specific embodiment, an adenoviral construct comprises a nucleic acid sequence encoding the peptide sequence MAEWQPDTAHHWALTLPDP (SEQ ID NO:10) inserted into the HI-loop of adenovirus fiber protein.

Abstract: An apparatus includes a movable member and a valve coupled to the movable member. The movable member is configured to be disposed within a housing of a medical device and has a first end portion and second end portion. A portion of the first end portion is configured to define a portion of a boundary of a gas chamber. The first end portion defines an opening configured to be in fluid communication between the gas chamber and an area outside the gas chamber. The second end portion is configured to be coupled to a needle configured to deliver a medicament into a body. The valve is configured to selectively allow fluid communication between the gas chamber and the area outside the gas chamber through the opening defined by the first end portion of the movable member.

Abstract: A method of monitoring power usage of a load includes defining one or more parameters of the load that vary with a mode of operation of the load, receiving measurement data related to the one or more parameters of the load over a first period of time, recording the measurement data, determining a plurality of groups, each group defining a set of measurements in a continuous range of values, each group having a lower threshold value and an upper threshold value, the lower and upper threshold values defined by having less than a minimum threshold number of recorded measurements of the lower and upper threshold values, and associating a mode of operation with each of the plurality of groups.

Abstract: The disclosure provides systems and methods of use pertaining to irrigating and thermally protecting a field of crops. One embodiment provides a semi-closed circuit irrigation and thermal-protection system that circulates heated irrigation fluid from a storage reservoir, through a fluid distribution system associated with each crop in the field, and back to the reservoir. The fluid distribution system incorporates a number of expandable, porous vessels associated with the crops. The vessels receive a large volume of irrigation fluid and, while slowly releasing the fluid into the soil to raise soil-saturation levels, transfer heat from the fluid directly to the crops and to the ambient environment. The system may be activated in discrete bursts to irrigate the crops or activated over a prolonged duration to heat the crops during a freeze or frost event. Other embodiments are also disclosed.

Abstract: An apparatus includes a movable member and a valve coupled to the movable member. The movable member is configured to be disposed within a housing of a medical device and has a first end portion and second end portion. A portion of the first end portion is configured to define a portion of a boundary of a gas chamber. The first end portion defines an opening configured to be in fluid communication between the gas chamber and an area outside the gas chamber. The second end portion is configured to be coupled to a needle configured to deliver a medicament into a body. The valve is configured to selectively allow fluid communication between the gas chamber and the area outside the gas chamber through the opening defined by the first end portion of the movable member.

Abstract: Compositions and methods are provided for sensitizing neoplastic cells to radiotherapy. The invention provides aptamer-inhibitory nucleic acid chimeras that selectively inliibit the expression of radiosensitizing genes in neoplastic cells expressing a cell surface molecule that binds the aptamer.

Abstract: An apparatus includes a label configured to be coupled to a medicament delivery device. The label includes a first surface and a second surface. The first surface is configured to be coupled to an outer surface of the medicament delivery device. The second surface includes a textual indicia. The label further includes an electronic circuit system configured to output an electronic signal.

Abstract: An apparatus includes a medicament container assembly, a movable assembly, and a spring. The medicament container assembly includes a first plunger defining a first volume, and a second plunger defining a second volume. The movable assembly includes a first movable member and a second movable member. The second movable member can move the second plunger within the medicament container assembly. The first movable member can move the first plunger in a first direction within the medicament container assembly to expel a contents of at least the first volume via a needle. The spring is configured to urge the needle in a second direction. The release portion of the first movable member is configured to contact the second movable member after the first movable member moves the first plunger to enable the spring to move the needle in the second direction.

Abstract: Medicament delivery devices and simulated medicament delivery devices are described herein. An apparatus includes a simulated medicament injector. The simulated medicament injector includes a battery isolation member and an electronic circuit system having a processor. The battery isolation member is configured to selectively decouple a battery from the processor.

Abstract: Electrophotographic (EP) streaking compensation is performed. A tonescale is measured for each column and a per-column gain computed to compensate for variations. An adjustment tonescale is determined and a per-column adjustment-tonescale gain computed to correct for remaining error after the per-column gain is applied. The two corrections are used together to provide improved compensation quality.

Abstract: The present invention relates to the field of virology. More specifically, the present invention relates to the use of viral constructs to detect and quantify circulating tumor cells. In one embodiment, the present invention provides an adenovirus construct comprising (a) a cell type specific promoter that drives adenoviral replication; and (b) at least one reporter gene incorporated into the viral Major Late Transcriptional Unit. In another embodiment, an adenovirus construct comprises (a) prostate selective pro-basin promoter operably linked to the El gene; and (b) prostate specific antigen enhancer operably linked to the probasin promoter.

Abstract: An apparatus includes a housing, a needle, a first energy storage member and a second energy storage member. The needle is movably disposed within the housing and is configured to be to be placed in fluid communication with a medicament container. The needle is configured to move between a first position and a second position. In its first position, the needle is contained within the housing. In its second position, at least a portion of the needle extends from the housing. The first energy storage member is disposed within the housing, and is configured to produce a first force when actuated. The second energy storage member is disposed within the housing, and is configured to be actuated in response to the first force to produce a second force to move the needle from the first needle position to the second needle position.

Abstract: The present invention relates to the field of viral gene therapy. More specifically, A the present invention provides compositions and methods for retargeting virus constructs. In one embodiment, the present invention provides an adenoviral construct comprising a nucleic acid encoding the peptide sequence MAE-X-PDP, wherein X is an antigen targeting peptide. In a more specific embodiment, an adenoviral construct comprises a nucleic acid sequence encoding the peptide sequence MAEWQPDTAHHWALTLPDP inserted into the HI-loop of adenovirus fiber protein.

Abstract: An apparatus includes a container defining an internal region configured to contain multiple medicament delivery devices, such as, for example, pen injectors, auto-injectors, inhalers or the like. The container includes an electronic circuit system configured to output a first electronic output associated with a first medicament delivery device contained within the internal region when the first medicament delivery device is removed from the internal region of the container. The electronic circuit system is further configured to output a second electronic output associated with a second medicament delivery device contained within the internal region when the second medicament delivery device is removed from the internal region of the container. The second electronic output is different than the first electronic output. At least one of the first electronic output or the second electronic output is associated with a use instruction.