Patents by Inventor Shawn Jennings

Shawn Jennings has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions targeting BCMA and methods of use thereof
    Patent number: 12290531
    Abstract: This present invention relates to BCMA binders (e.g. antibodies) and chimeric antigen receptor (CAR) constructs comprising a BCMA antigen binding molecule. The BCMA binders specifically bind to BCMA. The present BCMA CARs further comprise a hinge region (e.g., CD28 hinge), a transmembrane domain, and one or more intracellular NK cell signalling domains. NK cells expressing a BCMA CAR has increased efficacy in killing cancer cells. Provided herein also include therapeutic uses of the BCMA binders and BCMA CARs.
    Type: Grant
    Filed: April 19, 2024
    Date of Patent: May 6, 2025
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Michael Curley, Ertan Eryilmaz, Shawn Jennings, LeeAnn Talarico, Taylor Hickman, Christina Sheau Fen Wong, Kathryn Fraser, Haiqing Wang, Alessandra Piersigilli
  • COMPOSITIONS TARGETING BCMA AND METHODS OF USE THEREOF
    Publication number: 20240350544
    Abstract: This present invention relates to BCMA binders (e.g. antibodies) and chimeric antigen receptor (CAR) constructs comprising a BCMA antigen binding molecule. The BCMA binders specifically bind to BCMA. The present BCMA CARs further comprise a hinge region (e.g., CD28 hinge), a transmembrane domain, and one or more intracellular NK cell signalling domains. NK cells expressing a BCMA CAR has increased efficacy in killing cancer cells. Provided herein also include therapeutic uses of the BCMA binders and BCMA CARs.
    Type: Application
    Filed: April 19, 2024
    Publication date: October 24, 2024
    Inventors: Michael Curley, Ertan Eryilmaz, Shawn Jennings, LeeAnn Talarico, Taylor Hickman, Christina Sheau Fen Wong, Kathryn Fraser, Haiqing Wang, Alessandra Piersigilli
  • ANTI-ADGRE2 ANTIBODIES AND USES THEREOF
    Publication number: 20230018888
    Abstract: Antibodies, fragments thereof and fusion proteins that specifically bind to ADGRE2, are described, as well as methods of making and using such antibodies. Such antibodies, fusion proteins and fragments thereof are useful for the treatment and diagnosis of various autoimmune diseases and cancers, including, for example, acute myeloid leukemia.
    Type: Application
    Filed: April 25, 2022
    Publication date: January 19, 2023
    Inventors: Antara Banerjee, Xingyue He, Shawn Jennings