Patents by Inventor Shawn K. Pack

Shawn K. Pack has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for synthesizing compounds useful for treating hepatitis C
    Patent number: 7728027
    Abstract: The present disclosure generally relates to a process for synthesizing methyl ((1S)-1-(((2S)-2-(5-(4?-(2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-5-yl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate dihydrochloride salt. The present disclosure also generally relates to intermediates useful in this process.
    Type: Grant
    Filed: July 17, 2008
    Date of Patent: June 1, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: Shawn K. Pack, Peng Geng, Michael J. Smith, Jason Hamm
  • PROCESS FOR PREPARING TRIAZOLE SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES AND NOVEL SALT FORMS PRODUCED THEREIN
    Publication number: 20100076191
    Abstract: A process is provided for preparing triazole substituted azaindoleoxoacetic piperazine derivative. Novel intermediates produced in the above process, and novel N-1 and amorphous forms of a 1,2,3-triazole substituted azaindoloxoacetic piperazine derivatives and processes for producing such novel forms are also provided.
    Type: Application
    Filed: August 27, 2009
    Publication date: March 25, 2010
    Inventors: NACHIMUTHU SOUNDARARAJAN, Yuping Qiu, Wenhao Hu, David R. Kronenthal, Pierre Sirard, Jean Lajeunesse, Robert Droghini, Ramakrishnan Chidambaram, Xinhua Qian, Kenneth J. Natalie, Shawn K. Pack, Nathan Reising, Erqing Tang, Michael G. Fakes, Qi Gao, Feng Qian, Blisse J. Vakkalagadda, Chiajen Lai, Shan-Ming Kuang
  • Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein
    Patent number: 7601715
    Abstract: A process is provided for preparing triazole substituted azaindoleoxoacetic piperazine derivative. Novel intermediates produced in the above process, and novel N-1 and amorphous forms of a 1,2,3-triazole substituted azaindoloxoacetic piperazine derivatives and processes for producing such novel forms are also provided.
    Type: Grant
    Filed: June 19, 2006
    Date of Patent: October 13, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Nachimuthu Soundararajan, Yuping Qiu, Wenhao Hu, David R. Kronenthal, Pierre Sirard, Jean Lajeunesse, Robert Droghini, Ramakrishnan Chidambaram, Xinhua Qian, Kenneth J. Natalie, Shawn K. Pack, Nathan Reising, Erqing Tang, Michael G. Fakes, Qi Gao, Feng Qian, Blisse J. Vakkalagadda, Chiajen Lai, Shan-Ming Kuang
  • Process for Synthesizing Compounds Useful for Treating Hepatitis C
    Publication number: 20090043107
    Abstract: The present disclosure generally relates to a process for synthesizing methyl ((1S)-1-(((2S)-2-(5-(4?-(2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3- methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-5-yl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate dihydrochloride salt. The present disclosure also generally relates to intermediates useful in this process.
    Type: Application
    Filed: July 17, 2008
    Publication date: February 12, 2009
    Inventors: Shawn K. Pack, Peng Geng, Michael J. Smith, Jason Hamm
  • Process for the preparation of pyrazolo[1,5-a]-1,3,5-triazines and intermediates thereof
    Patent number: 7442792
    Abstract: The present invention provides novel processes and intermediates for preparing corticotropin releasing factor (CRF) receptor antagonists having the structure below which are useful in treating CRF-related disorders such as anxiety and depression.
    Type: Grant
    Filed: March 13, 2007
    Date of Patent: October 28, 2008
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: James P. Sherbine, Shawn K. Pack, Jaan A. Pesti, Robert E. Yule, Kenneth C. McNulty
  • Processes for the preparation of pyrazolo[1,5-a]-1,3,5-triazines and intermediates thereof
    Patent number: 7208596
    Abstract: The present invention provides novel processes and intermediates for preparing corticotropin releasing factor (CRF) receptor antagonists having the structure below which are useful in treating CRF-related disorders such as anxiety and depression
    Type: Grant
    Filed: November 10, 2004
    Date of Patent: April 24, 2007
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: James P. Sherbine, Shawn K. Pack, Jaan A. Pesti, Robert E. Yule, Kenneth C. McNulty
  • Preparation of [4S-(4.alpha.,7.alpha.,10a.beta.)]-4-amino-octahydro-5-oxo-7H-pyrido[2,1 -b] [1,3]thiazepine-7-carboxylic acid, methyl ester and salts thereof via novel disulfides
    Patent number: 6162913
    Abstract: N-protected-L-homocysteine disulfide of the formula ##STR1## or an activated form thereof is reacted with (S)-2-amino-6,6-dimethoxyhexanoic acid, methyl ester to give the disulfide intermediate of the formula ##STR2## Cleavage of the disulfide bond followed by acid catalyzed cyclization produces the N-protected lactam of formula III which is useful for preparing the pharmaceutically active compound omapatrilat.
    Type: Grant
    Filed: July 8, 1999
    Date of Patent: December 19, 2000
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Jerome L. Moniot, Sushil K. Srivastava, William J. Winter, John J. Venit, Shankar Swaminathan, Keith Ramig, Paul A. Jass, Mark D. Schwinden, John L. Dillon, Jr., Saibaba Racha, James Simpson, Chien-Kuang Chen, Shawn K. Pack