Patents by Inventor Shawn M. Nettles

Shawn M. Nettles has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Increasing enantioselectivity in reductions with borane reagents
    Patent number: 6610894
    Abstract: A method of increasing enantioselectivity in a reduction reaction of a prochiral substrate with a borane reagent including a borohydride species (for example, a borohydride stabilized borane-tetrahydrofuran complex) catalyzed by a chiral catalyst includes the step of maintaining the concentration of borohydride species in the borane reagent below approximately 0.005 M during the reduction of the prochiral substrate. A method of increasing enantioselectivity in a reduction reaction of a prochiral substrate with a borane reagent including a borohydride species that is catalyzed by a chiral catalyst includes the step of reducing the detrimental effect the borohydride species has on enantioselectivity by adding a Lewis acid. For example, the prochiral substrate can be a ketone and the chiral catalyst can be a chiral oxazaborolidine.
    Type: Grant
    Filed: January 26, 2001
    Date of Patent: August 26, 2003
    Assignee: Mine Safety Appliances Company
    Inventors: Karl Matos, Joseph A. Corella, II, Elizabeth R. Burkhardt, Shawn M. Nettles
  • Increasing enantioselectivity in reductions with borane reagents
    Publication number: 20010047116
    Abstract: A method of increasing enantioselectivity in a reduction reaction of a prochiral substrate with a borane reagent including a borohydride species (for example, a borohydride stabilized borane-tetrahydrofuran complex) catalyzed by a chiral catalyst includes the step of maintaining the concentration of borohydride species in the borane reagent below approximately 0.005 M during the reduction of the prochiral substrate. A method of increasing enantioselectivity in a reduction reaction of a prochiral substrate with a borane reagent including a borohydride species that is catalyzed by a chiral catalyst includes the step of reducing the detrimental effect the borohydride species has on enantioselectivity by adding a Lewis acid. For example, the prochiral substrate can be a ketone and the chiral catalyst can be a chiral oxazaborolidine.
    Type: Application
    Filed: January 26, 2001
    Publication date: November 29, 2001
    Applicant: Mine Safety Appliances Company
    Inventors: Karl Matos, Joseph A. Corella, Elizabeth R. Burkhardt, Shawn M. Nettles
  • Increasing enatioselectivity in reductions with borane reagents
    Patent number: 6218585
    Abstract: A method of increasing enantioselectivity in a reduction reaction of a prochiral substrate with a borane reagent including a borohydride species (for example, a borohydride stabilized borane-tetrahydrofuran complex) catalyzed by a chiral catalyst includes the step of maintaining the concentration of borohydride species in the borane reagent below approximately 0.005 M during the reduction of the prochiral substrate. A method of increasing enantioselectivity in a reduction reaction of a prochiral substrate with a borane reagent including a borohydride species that is catalyzed by a chiral catalyst includes the step of reducing the detrimental effect the borohydride species has on enantioselectivity by adding a Lewis acid. For example, the prochiral substrate can be a ketone and the chiral catalyst can be a chiral oxazaborolidine.
    Type: Grant
    Filed: April 20, 2000
    Date of Patent: April 17, 2001
    Assignee: Mine Safety Appliances Company
    Inventors: Karl Matos, Joseph A. Corella, II, Elizabeth R. Burkhardt, Shawn M. Nettles