Patents by Inventor Shawn O'Connor

Shawn O'Connor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant methods for expressing a functional umami (T1R1/T1R3) taste receptor
    Publication number: 20080050778
    Abstract: Methods for expressing a heteromeric taste receptor that responds to umami taste stimuli are provided. These methods comprise the co-expression of T1R1 and T1R3 nucleic acid sequences in a host cell that desirably also expresses a G protein that couples therewith, e.g., G?15 and G?16 or gustducin. In preferred embodiments, the host cells will be mammalian cells or Xenopus oocytes. These nucleic acid sequences are expressed constitutively or under inducible conditions. In preferred embodiments, the methods will yield mammalian cells that stably express a T1R1/T1R3 umami taste receptor under inducible conditions, e.g., HEK-293 cells that express G?15.
    Type: Application
    Filed: December 3, 2003
    Publication date: February 28, 2008
    Inventors: Mark Zoller, Xiaodong Li, Lena Staszewski, Shawn O'Connell, Sergey Zozulya, Jon Elliot Adler, Hong Xu, Femando Echeverri
  • Implantable heart assist system and method of applying same
    Patent number: 7331921
    Abstract: An extracardiac pumping for supplementing the circulation of blood, including the cardiac output, in a patient without any component thereof being connected to the patient's heart, and methods of using same. One embodiment of the intravascular extracardiac system comprises a pump with inflow and outflow conduits that are sized and configured to be implantable intravascularly through a non-primary vessel, whereby it may positioned where desired within the patient's vasculature. The system comprises a subcardiac pump that may be driven directly or electromagnetically from within or without the patient. The pump is configured to be operated continuously or in a pulsatile fashion, synchronous with the patient's heart, thereby potentially reducing the afterload of the heart.
    Type: Grant
    Filed: June 28, 2004
    Date of Patent: February 19, 2008
    Assignee: Orqis Medical Corporation
    Inventors: Anthony Viole, Laksen Sirimanne, Steven F. Bolling, Shawn O'Leary, Robert Pecor, Ryan Kelly, Wolfgang Werner, Masoud Beizai
  • T1R taste receptors and genes encoding same
    Publication number: 20080038741
    Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.
    Type: Application
    Filed: May 1, 2007
    Publication date: February 14, 2008
    Applicant: Senomyx, Inc.
    Inventors: Jon Adler, Sergey Zozulya, Xiadong Li, Shawn O'Connell, Lena Staszewski
  • Materials management system and method
    Publication number: 20080033598
    Abstract: A materials management system and method configured to handle materials events is provided. The materials management system can be configured to receive event information, comprising information pertaining to a hazardous materials event, to store data pertaining to a plurality of hazardous materials, to retrieve stored data based on the event information and to generate a materials event response based on the retrieved information. According to one embodiment, the materials management system can include an remote user interface for accepting user input and facilitating a system response.
    Type: Application
    Filed: December 22, 2006
    Publication date: February 7, 2008
    Inventors: Stephen Hollingsworth, Jeffrey Kacirek, Richard McCrea, Isaac Powell, Karlton Prillerman, Charles Hewison, Christopher Kraus, Shawn O'Brien, Joel Hawthorne
  • Chimeric human T1R3 taste receptor polyptides and compositions containing same
    Publication number: 20080026404
    Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.
    Type: Application
    Filed: May 1, 2007
    Publication date: January 31, 2008
    Applicant: Senomyx, Inc.
    Inventors: Jon Adler, Sergey Zozulya, Xiadong Li, Shawn O'Connell, Lena Staszewski
  • HETEROMERIC UMAMI T1R1/T1R3 TASTE RECEPTORS AND ISOLATED CELLS THAT EXPRESS SAME
    Publication number: 20080020424
    Abstract: The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners. Also the present invention relates to the use of hetero-oligomeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli. Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions.
    Type: Application
    Filed: June 26, 2002
    Publication date: January 24, 2008
    Applicant: Senomyx, Inc.
    Inventors: Mark Zoller, Xiaodong Li, Lena Staszewski, Shawn O'Connell, Sergey Zozulya, Jon Adler, Hong Xu, Fernando Echeverri
  • T1R Taste Receptors and Genes Encoding Same
    Publication number: 20070292944
    Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular taste stimulus in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.
    Type: Application
    Filed: May 8, 2007
    Publication date: December 20, 2007
    Applicant: Senomyx, Inc.
    Inventors: Jon ADLER, Xiaodong Li, Lena Staszewski, Shawn O'Connell, Sergey Zozulya
  • Binding assays that use the T1R1/T1R3 (umami) taste receptor to identify compounds that elicit or modulate umami taste
    Patent number: 7309577
    Abstract: Binding assays for identifying compounds that induce or modulate the T1R1/T1R3 (umami) receptor-associated taste are provided. These binding assays detect the specific binding of a compound to a T1R1/T1R3 (umami) taste receptor or detect the modulation (inhibition or enhancement) of the binding of another compound, e.g., L-glutamate, L-aspartate or lactisole to a T1R1/T1R3 umami taste receptor. Compounds that are identified in these binding assays have potential application as T1R1/T1R3 umami taste modulators and therefore can be used as flavor additives in compositions for human or animal consumption.
    Type: Grant
    Filed: December 3, 2003
    Date of Patent: December 18, 2007
    Assignee: Senomyx, Inc.
    Inventors: Mark Zoller, Xiaodong Li, Lena Staszewski, Shawn O'Connell, Sergey Zozulya, Jon Elliot Adler, Hong Xu, Fernando Echeverri
  • Functional assays for identifying compounds that modulate T1R1/T1R3 (umami) taste
    Patent number: 7303886
    Abstract: Functional assays for identifying compounds that activate or modulate the activation of the T1R1/T1R3 (umami) taste receptor are provided. These assays detect the effect of one or more compounds on the activation of T1R1/T1R3 (umami) taste receptor or on the activation of T1R1/T1R3 umami taste receptor by another compound e.g., monosodium glutamate, lactisole, or another unami taste modulator. These assays preferably are cell-based functional assays and typically use cells, e.g., HEK-293 cells that express a G protein such as G?15, G?16 or gustducin. Compounds identified in the disclosed functional assays are potentially useful as flavor additives in compositions for human or animal consumption.
    Type: Grant
    Filed: December 3, 2003
    Date of Patent: December 4, 2007
    Assignee: Senumyx, Inc.
    Inventors: Mark Zoller, Xiaodong Li, Lena Staszewski, Shawn O'Connell, Sergey Zozulya, Jon Elliot Adler, Hong Xu, Fernando Echeverri
  • Isolated (T1R1/T1R3) umami taste receptors that respond to umami taste stimuli
    Patent number: 7301009
    Abstract: Isolated or biologically pure taste receptors comprised of at least one T1R1 and T1R3 polypeptide and compositions containing are provided. These taste receptors specifically bind to and/or are specifically activated by umami taste stimuli such as glutamate compounds. These taste receptors are useful in screening assays for identifying compounds that elicit or modulate (enhance or inhibit) umami taste. Such compounds can be used as additives and flavorants to improve the taste of compositions for human or animal consumption. In preferred embodiments, the T1R1/T1R3 receptor will be comprised of human T1R1/human T1R3 expressed in association with a suitable G protein, e.g. G?15.
    Type: Grant
    Filed: December 2, 2003
    Date of Patent: November 27, 2007
    Assignee: Senomyx, Inc.
    Inventors: Mark Zoller, Xiaodong Li, Lena Staszewski, Shawn O'Connell, Sergey Zozulya, Jon Elliot Adler, Hong Xu, Fernando Echeverri
  • Devices, methods and systems for collecting material from a breast duct
    Publication number: 20070270708
    Abstract: The invention provides methods, devices and systems for collecting breast ductal fluid comprising cellular material and other useful markers for analysis. The methods typically comprise access of at least one breast duct and collecting materials from that duct separate from all other ducts in the breast. The devices comprise ductal access devices that provide the opportunity to collect fluid from a single duct separate from all the other ducts in the breast. The systems employ the methods and devices that used together provide systems for analysis of a breast condition in a patient specific to accessed breast ducts. The methods, devices and systems are particularly useful for indentification of breast precancer or cancer in patient.
    Type: Application
    Filed: July 24, 2007
    Publication date: November 22, 2007
    Inventors: David Hung, Christopher Ken, Xuanmin He, Phillip Olsen, Julian Nikolchev, Shawn O'Leary, Pam Sayavong
  • Isolated (T1R2/T1R3) sweet taste receptors that respond to sweet taste stimuli
    Patent number: 7297772
    Abstract: Isolated or biologically pure taste receptors comprised of at least one T1R2 and T1R3 polypeptide and compositions containing are provided. These taste receptors specifically bind and/or are specifically activated by sweet taste stimuli such as natural and artificial sweetener compounds. These taste receptors are useful in screening assays for identifying compounds that elicit or modulate (enhance or inhibit) sweet taste. These compounds can be used as additives and flavorants to improve the taste of compositions for human or animal consumption. In preferred embodiments, the T1R2/T1R3 receptor will be comprised of human T1R2/human T1R3 expressed in association with a suitable G protein, preferably Gaa15.
    Type: Grant
    Filed: December 2, 2003
    Date of Patent: November 20, 2007
    Assignee: Senomyx, Inc.
    Inventors: Mark Zoller, Xiaodong Li, Lena Staszewski, Shawn O'Connell, Sergey Zozulya, Jon Elliot Adler, Hong Xu, Fernando Echeverri
  • Cell lines that stably or transiently express a functional sweet (T1R2/T1R3) taste receptor
    Patent number: 7297543
    Abstract: Cells are engineered to stably or transiently express T1R2 and T1R3 polypeptides, desirably in association with a G protein. The resultant heteromeric taste receptor is a sweet taste receptor and responds to sweet taste stimuli such as artificial and natural sweeteners, e.g., saccharin. The invention provides a preferred mammalian cell lines, e.g., HEK-293 cells that stably express T1R2/T1R3 and G?15 under inducible conditions. These cells are useful in cell-based assays for identifying compounds that elicit or modulate sweet taste.
    Type: Grant
    Filed: December 2, 2003
    Date of Patent: November 20, 2007
    Assignee: Senomyx, Inc.
    Inventors: Mark Zoller, Xiaodong Li, Lena Staszewski, Shawn O'Connell, Sergey Zozulya, Jon Elliot Adler, Hong Xu, Fernando Echeverri
  • Functional assays for identifying compounds that modulate T1R2/T1R3 (sweet) taste
    Patent number: 7294474
    Abstract: Functional assays for identifying compounds that activate or modulate the activation of the T1R2/T1R3 (sweet) taste receptor are provided. These assays detect the effect of one or more compounds on the activation of T1R2/T1R3 (sweet) taste receptor or on the activation of T1R2/T1R3 sweet taste receptor by another, compound e.g., saccharin or another artificial or natural sweetener. These assays preferably are cell-based functional assays and typically use cells, e.g., HEK-293 cells that stably express a G protein such as G?15, G?16 or gustducin. Compounds identified in the disclosed functional assays are potentially useful as additives in compositions for human or animal consumption.
    Type: Grant
    Filed: December 3, 2003
    Date of Patent: November 13, 2007
    Assignee: Senomyx, Inc.
    Inventors: Mark Zoller, Xiaodong Li, Lena Staszewski, Shawn O'Connell, Sergey Zozulya, Jon Elliot Adler, Hong Xu, Fernando Echeverri
  • Opt-in data communication to wireless devices
    Publication number: 20070224979
    Abstract: A method and apparatus for providing opt-in data communications to a user of a wireless device such as a mobile telephone is provided. The user can call a telephone number associated with an interactive voice response unit, towards opting in to receipt of digital messaging, such as advertising or marketing material. In response, information captured during the telephone call can be used to prepare, format and transmit digital messaging to the user.
    Type: Application
    Filed: March 21, 2006
    Publication date: September 27, 2007
    Inventors: Shawn O'Neal, John Maier
  • Blood conduit connector
    Publication number: 20070213690
    Abstract: A conduit for use with a blood pump can have a flared inner surface at an end of the conduit. In some embodiments, the conduit can include a strain relief member such as overmolded silicone. The strain relief member can maintain the profile of the flared inner surface. A conduit with a flared inner surface can be configured for connection to a blood pump via a connector. For example, the conduit can include an anchor member such as flange configured to engage with various components of a connector to connect the conduit to a fitting on a pump or another structure. In some embodiments, the conduit can be configured to connect to a blood conduit connector including a member such as a compression collet and a fitting such as a coupler. The connector can include a bayonet connection to facilitate rapid connection and disconnection of the conduit from a fitting.
    Type: Application
    Filed: March 8, 2006
    Publication date: September 13, 2007
    Inventors: Nickolas Phillips, Anthony Viole, Michael Scott, Robert Pecor, Shawn O'Leary, Dominic Dinh
  • T1R taste receptors and genes encoding same
    Patent number: 7244835
    Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.
    Type: Grant
    Filed: March 7, 2001
    Date of Patent: July 17, 2007
    Assignee: Senomyx, Inc.
    Inventors: Jon Elliot Adler, Sergey Zozulya, Xiadong Li, Shawn O'Connell, Lena Staszewski
  • T1R taste receptors and genes encoding same
    Patent number: 7241880
    Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular taste stimulus in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.
    Type: Grant
    Filed: January 3, 2002
    Date of Patent: July 10, 2007
    Assignee: Senomyx, Inc.
    Inventors: Jon Elliot Adler, Xiaodong Li, Lena Staszewski, Shawn O'Connell, Sergey Zozulya
  • T1R3 receptor binding assays for identification of taste modulatory compounds
    Patent number: 7223551
    Abstract: Binding assays for identifying ligands that modulate human T1R3 polypeptide-associated taste are disclosed. These assays detect the specific binding of compounds to a human T1R3 polypeptide or the modulation of the specific binding of another compound that specifically binds human T1R3 polypeptide. The binding assays may include the use of detectable labels, e.g., radionuclides, enzymes, fluorophores, and the like. Compounds identified in these binding assays have potential application as T1R3 taste modulators and therefore potentially are useful additives in compositions for human or animal consumption.
    Type: Grant
    Filed: December 4, 2003
    Date of Patent: May 29, 2007
    Assignee: Senomyx, Inc.
    Inventors: Jon Elliot Adler, Sergey Zozulya, Xiadong Li, Shawn O'Connell, Lena Staszewski
  • Multi-functional joint brace
    Publication number: 20070106189
    Abstract: A multi-functional brace for a joint includes a releasable locking mechanism that allows the brace to be set for static stretch of the joint in either flexion or extension, and a range of motion assembly that allows for free movement of the joint through its natural axis over a controlled range of motion when the locking mechanism is released.
    Type: Application
    Filed: November 21, 2006
    Publication date: May 10, 2007
    Applicant: DJO, LLC
    Inventors: Scott Salmon, Dan Ueda, Robert Joachim, Mario Turchi, David Hargrave, Bernard Morrey, Shawn O'Driscoll, Robert Adams