Abstract: A method and apparatus for the transmission of multiple control characters of the same type to a receiver to improve the retention of transmitter to receiver synchronization in a noisy environment having receiver code that is less complex and does not require an increase in the bandwidth of the system since the control codes are already utilized to initiate other functions. Detection of any of the control characters of the same type by the receiver allows the receiver to maintain proper synchronization. The receiver will detect these control signals and anticipate the occurrence of an event within a predetermined time period.

Abstract: A method and apparatus for transmitting and receiving image data and control characters across an interface that is subject to noise for output to a printer. The image data and the control characters are transmitted across the interface to a receiver device. A determination is made as to whether or not a line of image data has been sufficiently transferred to the receiver device and, if the current line of image data has not been sufficiently transferred, there is provided for output to the printer a prior sufficiently received line of image data in replacement of the current line of image data so that the prior line of image data is printed at least twice in succession.

Abstract: A highly sensitive assay is disclosed which utilizes a method for gene specific primed amplification of mRNA libraries from rare cells and rare transcripts found in blood. The assay allows detection of rare mRNA (10 copies/cell) found in 1 to 10 cells isolated through immunomagnetic enrichment. The assay is an improvement over multiplex PCR and allows efficient detection of rare coding sequences for circulating carcinoma cells in the blood. The methods are useful in profiling of cells isolated from tissues or body fluids and serves as an adjunct to clinical diagnosis of diverse carcinomas including early stage detection and classification of circulating tumor cells. Monitoring of nucleic acid and protein profiles of cells either in conventional or microarray formats, facilitates management of therapeutic intervention including staging, monitoring response to therapy, confirmation of remission and detection of regression.

Abstract: A driver IC (60) for a printhead includes a first set of data side input/output pads (62) and a second set of data side input/output pads (63). The driver IC further includes circuitry (100) that can select that data is to be input at the first set of pads and output at the second set of pads.

Abstract: The methods and reagents described in this invention are used to analyze circulating tumor cells, clusters, fragments, and debris. Analysis is performed with a number of platforms, including flow cytometry and the CellSpotter® fluorescent microscopy imaging system. Analyzing damaged cells has shown to be important. However, there are two sources of damage: in vivo and in vitro. Damage in vivo occurs by apoptosis, necrosis, or immune response. Damage in vitro occurs during sample acquisition, handling, transport, processing, or analysis. It is therefore desirable to confine, reduce, eliminate, or at least qualify in vitro damage to prevent it from interfering in analysis. Described herein are methods to diagnose, monitor, and screen disease based on circulating rare cells, including malignancy as determined by CTC, clusters, fragments, and debris. Also provided are kits for assaying biological specimens using these methods.

Abstract: A method and system to improve the retention of synchronization between the transmitter and receiver of image data across a communication channel. If the control character designating the end of the line of data is corrupted, the receiving system will not recognize that the line of data has ended and will continue as if data is still being received. The corruption of a single bit in the control character will cause the receiver to misinterpret the end of line control word. Since the receiving logic does not realize the transmitter is no longer sending data, erroneous data will be stored in the storage elements. By using an alternate control character as an additional end of line indicator, the receiver will terminate the line of data and will wait for the next start of line control character from the transmitter. Synchronization between the transmitter and receiver across the communication channel is thus maintained.

Abstract: A driver IC (21) for a flexible printhead (20) includes a plurality of registers (105) corresponding to exposure elements and a token input (31). The driver IC further includes circuitry (100) coupled to the registers. The circuitry is adapted to bypass received data from the registers in response to a token received from the token input.