Patents by Inventor Shawn R. Campagna

Shawn R. Campagna has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Expeditious synthesis of DPD
    Patent number: 7652172
    Abstract: This invention provides a practical synthesis route for 4,5-dihydroxypentane-2,3-dione (DPD), an unstable small molecule which is proposed to be the source of universal signaling agents for quorum sensing in bacteria. The synthesis route includes new intermediates and allows preparation of isotopically-labeled DPD and ent-DPD. The method provides sufficient quantities of DPD for study of spontaneous binding of borate to DPD, the signal for the marine bacteria V. harveyi.
    Type: Grant
    Filed: September 20, 2005
    Date of Patent: January 26, 2010
    Assignee: The Trustees of Princeton University
    Inventors: Martin F. Semmelhack, Shawn R. Campagna, Bonnie L. Bassler, Michael J. Federle
  • AI-2 compounds and analogs based on Salmonella typhimurium LsrB structure
    Publication number: 20090286873
    Abstract: This invention relates to crystals comprising apo-LsrB and holo-LsrB. The structure of holo-LsrB identifies a tetrahydroxytetrahydrofuran derived from 4,5-dihydroxy-2,3-pentanedione (DPD) as the active autoinducer-2 (AI-2) molecule in Salmonella typhimurium. The X-ray crystallographic data can be used in a drug discovery method. Additionally the invention provides AI-2 analogs based on this discovery as well as pharmaceutical compositions containing those analogs.
    Type: Application
    Filed: March 13, 2009
    Publication date: November 19, 2009
    Inventors: Stephen T. Miller, Karina B. Xavier, Michiko E. Taga, Shawn R. Campagna, Martin F. Semmelhack, Bonnie L. Bassler, Frederick M. Hughson
  • AI-2 compounds and analogs based on LsrB structure
    Patent number: 7547726
    Abstract: This invention relates to crystals comprising apo-LsrB and holo-LsrB. The structure of holo-LsrB identifies a tetrahydroxytetrahydrofuran derived from 4,5-dihydroxy-2,3-pentanedione (DPD) as the active autoinducer-2 (AI-2) molecule in Salmonella typhimurium. The X-ray crystallographic data can be used in a drug discovery method. Additionally the invention provides AI-2 analogs based on this discovery as well as pharmaceutical compositions containing those analogs.
    Type: Grant
    Filed: September 16, 2005
    Date of Patent: June 16, 2009
    Assignee: The Trustees of Princeton University
    Inventors: Stephen T. Miller, Karina B. Xavier, Michiko E. Taga, Shawn R. Campagna, Martin F. Semmelhack, Bonnie L. Bassler, Frederick M. Hughson
  • EXPEDITIOUS SYNTHESIS OF DPD
    Publication number: 20090018368
    Abstract: This invention provides a practical synthesis route for 4,5-dihydroxypentane-2,3-dione (DPD), an unstable small molecule which is proposed to be the source of universal signaling agents for quorum sensing in bacteria. The synthesis route includes new intermediates and allows preparation of isotopically-labeled DPD and ent-DPD. The method provides sufficient quantities of DPD for study of spontaneous binding of borate to DPD, the signal for the marine bacteria V.
    Type: Application
    Filed: September 20, 2005
    Publication date: January 15, 2009
    Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Martin F. Semmelhack, Shawn R. Campagna, Bonnie L. Bassler, Michael J. Federle