Patents by Inventor Shawn R. Feaster

Shawn R. Feaster has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20080057528
    Abstract: A diagnostic test kit for detecting hydrogen peroxide released by enzyme-catalyzed oxidation of an analyte within a test sample is provided. The test kit comprises a lateral flow device that contains a chromatographic medium, wherein the chromatographic medium defines a detection zone within which a chromogen is substantially non-diffusively immobilized in conjunction with an anionic compound. The chromogen is a leuco base, or a derivative thereof, which is capable of undergoing a detectable color change upon oxidation.
    Type: Application
    Filed: August 30, 2006
    Publication date: March 6, 2008
    Inventors: Curtis Sayre, Shawn R. Feaster
  • Patent number: 7279136
    Abstract: A diagnostic method and associated test kit for detecting an analyte residing in a test sample is provided. A sample membrane is utilized having a collection region and a detection region, the collection region having a known saturation volume for the intended test sample. A barrier is defined between the collection region and the detection region. The collection region is saturated with the test sample having a volume of less than about 100 microliters so that a known volume of the test sample is contained in the collection region. The barrier is removed from between the collection region and detection region of the membrane and a diluent is supplied to the collection region of the membrane to facilitate flow of the test sample from the collection region to the detection region of the membrane.
    Type: Grant
    Filed: December 13, 2005
    Date of Patent: October 9, 2007
    Inventors: James M. Takeuchi, Xuedong Song, Kaiyuan Yang, Ning Wei, Shawn R. Feaster
  • Publication number: 20070141934
    Abstract: Nonwoven webs, such as coform webs, treated with a bacteriostatic composition are generally disclosed. The treated webs can attract and/or trap negatively charged matter, such as bacteria and other pathogens. The bacteriostatic composition can comprise a cationic polymer, a cationic oligomer, or particles coated with a cationic material. The bacteriostatic composition can be bonded to the fibers of the nonwoven web in a manner such that the bacteriostatic composition is not substantially transferable to the web's surrounding environment.
    Type: Application
    Filed: December 15, 2005
    Publication date: June 21, 2007
    Inventors: Curtis N. Sayre, Shawn R. Feaster, Julie Villanueva
  • Publication number: 20040152145
    Abstract: An assay for detecting, measuring, or monitoring the activity or concentration of at least two proteins that have similar or overlapping properties is disclosed. The assay comprises first determining the sensitivity coefficients of the substrates for each of the proteins in which the concentrations are to be determined. This method may be used for detecting, measuring, or monitoring the activity and concentration of AChE, BChE, or both in a test sample which test sample may be whole and unprocessed blood or tissue. Also disclosed are methods of using the assay to detect a subject's exposure to an agent which affects cholinesterase, determine the efficacy or progress of a treatment, determine the amount of protection provided against exposure to an agent which affects cholinesterase, or both, screen a subject for having a drug sensitivity or a particular disease, detect a change in red blood cell count of a subject, determine whether a candidate compound affects cholinesterase.
    Type: Application
    Filed: January 26, 2004
    Publication date: August 5, 2004
    Inventors: Shawn R. Feaster, Richard K. Gordon, Bhupendra P. Doctor
  • Patent number: 6746850
    Abstract: An assay for detecting, measuring, or monitoring the activity or concentration of at least two proteins that have similar or overlapping properties is disclosed. The assay comprises first determining the sensitivity coefficients of the substrates for each of the proteins in which the concentrations are to be determined. This method may be used for detecting, measuring, or monitoring the activity and concentration of AChE, BChE, or both in a test sample which test sample may be whole and unprocessed blood or tissue. Also disclosed are methods of using the assay to detect a subject's exposure to an agent which affects cholinesterase, determine the efficacy or progress of a treatment, determine the amount of protection provided against exposure to an agent which affects cholinesterase, or both, screen a subject for having a drug sensitivity or a particular disease, detect a change in red blood cell count of a subject, determine whether a candidate compound affects cholinesterase.
    Type: Grant
    Filed: May 4, 2001
    Date of Patent: June 8, 2004
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Shawn R. Feaster, Richard K. Gordon, Bhupendra P. Doctor
  • Publication number: 20040005681
    Abstract: A material comprising a porous support and a plurality of enzymes for the removal, decontamination or neutralization of hazardous chemicals such as OP compounds is disclosed. The material may be used on a variety of surfaces, including natural, synthetic and biological surfaces such as skin and other delicate membranes. Also disclosed is a process of making the material, kits and various methods and reactivation devices for reactivating the enzymatic activity of the material.
    Type: Application
    Filed: July 2, 2003
    Publication date: January 8, 2004
    Inventors: Richard K. Gordon, Bhupendra P. Doctor, Ashima Saxena, Shawn R. Feaster, Donald Maxwell, Michelle Ross, David Lenz, Keith LeJeune, Alan Russell
  • Patent number: 6642037
    Abstract: An enzymatically active reusable sponge or foam, capable of regeneration with oximes, made of a polymer such as polyurethane is prepared for detoxification of hazardous compounds such as organophosphorus and organosulfur compounds. The foam or sponge contains a plurality of enzymes including enzymes selected from acetylcholinesterase, butyrylcholinesterase, triesterase, pseudocholinesterase, organophosphate hydrase, phosphotriesterase, paraoxonase and organophosphorus and organosulfur hydrolyzing enzymes. The sponge or foam may additionally contain activated carbon and an enzyme reactivation compound. A kit can be formed containing the sponge or foam and the compound for enzyme reactivation. The enzymatically active foam or sponge may be prepared using a two chamber device where enzymes and prepolymer are passed from separate chambers into a static mixing stator and are subjected to low shear mixing and extrusion to form by the sponge or foam.
    Type: Grant
    Filed: April 26, 2000
    Date of Patent: November 4, 2003
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Richard K. Gordon, Bhupendra P. Doctor, Ashima Saxena, Shawn R. Feaster, Donald Maxwell, Michelle Ross, David Lenz, Keith Lejeune, Alan Russell
  • Publication number: 20030113902
    Abstract: A material comprising a porous support and a plurality of enzymes for the removal, decontamination or neutralization of hazardous chemicals such as OP compounds is disclosed. The material may be used on a variety of surfaces, including natural, synthetic and biological surfaces such as skin and other delicate membranes. Also disclosed is a process of making the material, kits and various methods and reactivation devices for reactivating the enzymatic activity of the material.
    Type: Application
    Filed: April 26, 2000
    Publication date: June 19, 2003
    Inventors: Richard K. Gordon, Bhupendra P. Doctor, Ashima Saxena, Shawn R. Feaster, Donald Maxwell, Michelle Ross, David Lenz, Keith Lejeune, Alan Russell, Gregory E. Garcia
  • Publication number: 20020165620
    Abstract: An assay for detecting, measuring, or monitoring the activity or concentration of at least two proteins that have similar or overlapping properties is disclosed. The assay comprises first determining the sensitivity coefficients of the substrates for each of the proteins in which the concentrations are to be determined. This method may be used for detecting, measuring, or monitoring the activity and concentration of AChE, BChE, or both in a test sample which test sample may be whole and unprocessed blood or tissue. Also disclosed are methods of using the assay to detect a subject's exposure to an agent which affects cholinesterase, determine the efficacy or progress of a treatment, determine the amount of protection provided against exposure to an agent which affects cholinesterase, or both, screen a subject for having a drug sensitivity or a particular disease, detect a change in red blood cell count of a subject, determine whether a candidate compound affects cholinesterase.
    Type: Application
    Filed: May 4, 2001
    Publication date: November 7, 2002
    Inventors: Shawn R. Feaster, Richard K. Gordon, Bhupendra P. Doctor
  • Patent number: 6406876
    Abstract: Methods, compositions and materials useful in the detection of organophosphorous and organosulfur compounds are disclosed. In particular, biosensors wherein a porous or a non-porous support having an enzyme immobilized upon or within are disclosed. The biosensors exhibit enzymatic stability at extreme temperatures and/or denaturing conditions, and similar kinetic characteristics of the soluble form of the enzymes utilized. The enzyme does not leach from the porous or non-porous support and the material retains enzymatic activity after prolonged storage. Differential biosensors are also disclosed.
    Type: Grant
    Filed: April 26, 2000
    Date of Patent: June 18, 2002
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Richard K. Gordon, Bhupendra P. Doctor, Ashima Saxena, Shawn R. Feaster, Donald Maxwell, Michelle Ross, David Lenz, Keith LeJeune, Alan Russell