Abstract: A portable flight navigation tool has a tablet computer with GPS, and memory with an aviation database with international operating rules including transoceanic flight rules, a moving-map database with tracks, coastal airport identifiers and locations, and predefined reporting point locations for transoceanic operations. The navigation tool includes machine readable code for displaying the operating rules, reading locations from the GPS while indicating them on a moving map display, and a trip database with a planned transoceanic route for an individual flight configured by entry of waypoints or names and selection of predefined tracks. The tool has a checklist database and displays checklists for pre-departure, coast-out flight phase, waypoint-reached, and a coast-in flight phases; and may provide a heading and next-waypoint timing for rhumb-line routes from GPS failure locations to the next waypoint of the active route. The tool links as a primary/secondary pair with another like tool.

Abstract: Methods and systems for monitoring use, determining risk, and pricing insurance policies for a vehicle having one or more autonomous or semi-autonomous operation features are provided. According to certain aspects, an identity of a vehicle operator may be determined and a vehicle operator profile and/or operating data regarding autonomous operation features of the vehicle may be received after the vehicle operator opts into a rewards program and agrees to share their data. Autonomous operation and vehicle operator risk levels associated with operation of the autonomous or semi-autonomous vehicle may be determined. Based upon the risk levels and/or comparison thereof, one or more autonomous operation features may be disengaged. A preparedness level of the vehicle operator to assume or reassume control of operating the vehicle is determined prior to disengagement. If satisfactory, an alert is presented to the vehicle operator prior to disengagement of the autonomous operation features.

Abstract: Systems, devices, and methods for additive manufacturing of objects are provided. In some embodiments, a system for fabricating an object includes a flexible substrate, a carriage coupled to the flexible substrate, an actuator, at least one recoater supported by the carriage, and an energy source. The flexible substrate can be configured to carry a precursor material. The carriage can vertically displace an active region of the flexible substrate away from a remaining region of the flexible substrate and toward a build platform. The actuator can be configured to move the carriage relative to the flexible substrate. The at least one recoater can be configured to apply the precursor material to the flexible substrate. The energy source can be configured to output energy toward the precursor material at the active region of the flexible substrate to form a portion of an object on the build platform.

Abstract: The present disclosure provides antibodies to V-domain Ig-containing Suppressor of T cell Activation (VISTA) and compositions comprising such antibodies. Also provided are methods of using antibodies that specifically binds to VISTA to treat diseases, e.g., to treat cancer.

Abstract: According to certain aspects, a computer-implemented method for operating an autonomous or semi-autonomous vehicle may be provided. With the customer's permission, an identity of a vehicle operator may be identified and a vehicle operator profile may be retrieved. Operating data regarding autonomous operation features operating the vehicle may be received from vehicle-mounted sensors. When a request to disable an autonomous feature is received, a risk level for the autonomous feature is determined and compared with a driver behavior setting for the autonomous feature stored in the vehicle operator profile. Based upon the risk level comparison, the autonomous vehicle retains control of vehicle or the autonomous feature is disengaged depending upon which is the safer driver—the autonomous vehicle or the vehicle human occupant. As a result, unsafe disengagement of self-driving functionality for autonomous vehicles may be alleviated.

Abstract: The present disclosure is directed to compounds of Formula (1): wherein m, n, Y, R1, R2, R3, R4 and R5 are each as described herein, as stereoisomers, enantiomers or tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, and pharmaceutical compositions comprising the compounds of Formula (I), as described herein, which are useful as voltage-gated potassium channel modulators and are therefore are useful in treating seizure disorders such as epilepsy.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.

Abstract: Wheelbarrow accessories are presented including: a base for mechanically coupling with a pair of wheelbarrow arms; and an extendable arm assembly mechanically coupled with the base where the extendable arm assembly is vertically adjustable, the extendable arm assembly including; an outer arm pivotally engaged with the base; an inner arm slidingly engaged with the outer arm along an inner surface of the outer arm, where the inner arm is adjustable to a number of extendable arm lengths; a pad base coupled with the inner arm along a distal end of the inner arm; and a pad coupled with the pad base.

Abstract: A portable flight navigation tool has a tablet computer with GPS, and memory with an aviation database with international operating rules including transoceanic flight rules, a moving-map database with tracks, coastal airport identifiers and locations, and predefined reporting point locations for transoceanic operations. The navigation tool includes machine readable code for displaying the operating rules, reading locations from the GPS while indicating them on a moving map display, and a trip database with a planned transoceanic route for an individual flight configured by entry of waypoints or names and selection of predefined tracks. The tool has a checklist database and displays checklists for pre-departure, coast-out flight phase, waypoint-reached, and a coast-in flight phases; and may provide a heading and next-waypoint timing for rhumb-line routes from GPS failure locations to the next waypoint of the active route. The tool links as a master/secondary pair with another like tool.

Abstract: A powered secondary air supply ranger burner and method thereof provide an efficient burner with improved heat transfer. An atmospheric range burner controls a burner flame by insulating the burner and supplying a secondary air to the burner. The secondary air concentrates a heating zone to a center of a cooking vessel to be heated by the burner flame. The secondary air also controls a size and a shape of the burner flame.

Abstract: A portable flight navigation tool has a tablet computer with GPS, and memory with an aviation database with international operating rules including transoceanic flight rules, a moving-map database with tracks, coastal airport identifiers and locations, and predefined reporting point locations for transoceanic operations. The navigation tool includes machine readable code for displaying the operating rules, reading locations from the GPS while indicating them on a moving map display, and a trip database with a planned transoceanic route for an individual flight configured by entry of waypoints or names and selection of predefined tracks. The tool has a checklist database and displays checklists for pre-departure, coast-out flight phase, waypoint-reached, and a coast-in flight phases; and may provide a heading and next-waypoint timing for rhumb-line routes from GPS failure locations to the next waypoint of the active route. The tool links as a master/secondary pair with another like tool.

Abstract: A portable flight navigation tool has a tablet computer with GPS, and memory with an aviation database with international operating rules including transoceanic flight rules, a moving-map database with tracks, coastal airport identifiers and locations, and predefined reporting point locations for transoceanic operations. The navigation tool includes machine readable code for displaying the operating rules, reading locations from the GPS while indicating them on a moving map display, and a trip database with a planned transoceanic route for an individual flight configured by entry of waypoints or names and selection of predefined tracks. The tool has a checklist database and displays checklists for pre-departure, coast-out flight phase, waypoint-reached, and a coast-in flight phases; and may provide a heading and next-waypoint timing for rhumb-line routes from GPS failure locations to the next waypoint of the active route. The tool links as a master/secondary pair with another like tool.

Abstract: A powered secondary air supply ranger burner and method thereof provide an efficient burner with improved heat transfer. An atmospheric range burner controls a burner flame by insulating the burner and supplying a secondary air to the burner. The secondary air concentrates a heating zone to a center of a cooking vessel to be heated by the burner flame. The secondary air also controls a size and a shape of the burner flame.

Abstract: A burner assembly including a burner box with an inlet for the introduction of a combustible mixture and a block plate integrated with the burner box. The block plate assists in a desired distribution of the combustible mixture. A distribution plate overlying the block plate and a single mesh surface above the distribution plate contribute to overall improved pressure and distribution of heat across the burner assembly.

Abstract: A portable flight navigation tool has a tablet computer with GPS, and memory with an aviation database with international operating rules including transoceanic flight rules, a moving-map database with tracks, coastal airport identifiers and locations, and predefined reporting point locations for transoceanic operations. The navigation tool includes machine readable code for displaying the operating rules, reading locations from the GPS while indicating them on a moving map display, and a trip database with a planned transoceanic route for an individual flight configured by entry of waypoints or names and selection of predefined tracks. The tool has a checklist database and displays checklists for pre-departure, coast-out flight phase, waypoint-reached, and a coast-in flight phases; and may provide a heading and next-waypoint timing for rhumb-line routes from GPS failure locations to the next waypoint of the active route. The tool links as a master/secondary pair with another like tool.

Abstract: An under-fired grill includes a grate formed with a spaced plurality of metal burner shields each having a curved top support surface and two downward extending legs, wherein food is placed directly on the grate formed by a plurality of top support surfaces of the burner shields for cooking. Each burner shield includes an integrated burner formed below the top support surface.

Abstract: A fryer unit combination includes a frying fluid vat and an associated heat exchange system whereby increased or greater efficiencies and/or heat transfers can be obtained and realized. The heat exchange system includes a first heat exchanger arrangement at least in part disposed within the frying fluid vat and a second heat exchanger arrangement disposed externally to the frying fluid vat. In the first heat exchanger arrangement, a heat exchange tube is in heat flow communication with a combustion chamber wherein an associated gaseous fuel burner is at least in part housed. The second heat exchanger arrangement includes at least a first side heat exchanger disposed externally adjacent the first side of the frying fluid vat. The side heat exchanger(s) may permit intake of an oxygen-containing gas such to preheat the oxygen-containing gas prior to entrance into the combustion chamber.

Abstract: Described is a method for using an embroidery machine or sewing machine to form shapes in, and extract shapes from, a sheet of material. A needle-based machine uses its needle to generate a series of perforations to cut out or assist in the separation of the shapes. Stitching facilitates operation of the machine. Preferably, perforations are made with a computer-controlled machine using instructions generated from or available in an electronic file.

Abstract: A fryer unit combination includes a frying fluid vat and an associated heat exchange system whereby increased or greater efficiencies and/or heat transfers can be obtained and realized. The heat exchange system includes a first heat exchanger arrangement at least in part disposed within the frying fluid vat and a second heat exchanger arrangement disposed externally to the frying fluid vat. In the first heat exchanger arrangement, a heat exchange tube is in heat flow communication with a combustion chamber wherein an associated gaseous fuel burner is at least in part housed. The second heat exchanger arrangement includes at least a first side heat exchanger disposed externally adjacent the first side of the frying fluid vat. The side heat exchanger(s) may permit intake of an oxygen-containing gas such to preheat the oxygen-containing gas prior to entrance into the combustion chamber.

Abstract: Described is a method for using an embroidery machine or sewing machine to form shapes in, and extract shapes from, a sheet of material. A needle-based machine uses its needle to generate a series of perforations to cut out or assist in the separation of the shapes. Stitching facilitates operation of the machine. Preferably, perforations are made with a computer-controlled machine using instructions generated from or available in an electronic file.