Patents by Inventor Shawn Stachel

Shawn Stachel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cathepsin cysteine protease inhibitors
    Patent number: 9656990
    Abstract: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: May 23, 2017
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Shawn Stachel, Daniel V. Paone, Jing Li, Anthony Ginnetti, Jianmin Fu, Shimin Xu
  • Cathepsin cysteine protease inhibitors
    Patent number: 9573913
    Abstract: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
    Type: Grant
    Filed: October 3, 2014
    Date of Patent: February 21, 2017
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Shawn Stachel, Daniel V. Paone, Jing Li, Anthony Ginnetti, John Lim, Jianmin Fu, Shimin Xu
  • CATHEPSIN CYSTEINE PROTEASE INHIBITORS
    Publication number: 20160355502
    Abstract: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
    Type: Application
    Filed: February 6, 2015
    Publication date: December 8, 2016
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Shawn Stachel, Daniel V. Paone, Jing Li, Anthony Ginnetti, Jianmin Fu, Shimin Xu
  • Cathepsin cysteine protease inhibitors
    Patent number: 9458181
    Abstract: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
    Type: Grant
    Filed: October 6, 2014
    Date of Patent: October 4, 2016
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Shawn Stachel, Daniel V. Paone, Jing Li, Kausik Nanda
  • CATHEPSIN CYSTEINE PROTEASE INHIBITORS
    Publication number: 20160244417
    Abstract: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
    Type: Application
    Filed: October 3, 2014
    Publication date: August 25, 2016
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Shawn STACHEL, Jing LI, Anthony GINNETTI
  • CATHEPSIN CYSTEINE PROTEASE INHIBITORS
    Publication number: 20150099719
    Abstract: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
    Type: Application
    Filed: October 6, 2014
    Publication date: April 9, 2015
    Inventors: Shawn Stachel, Daniel V. Paone, Jing Li, Kausik Nanda
  • 2,4,6-Substituted Pyridyl Derivative Compounds Useful as Beta-Secretase Inhibitors for the Treatment of Alzheimer's Disease
    Publication number: 20080015233
    Abstract: The present invention is directed to 2,4,6-substituted pyridyl derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
    Type: Application
    Filed: April 20, 2005
    Publication date: January 17, 2008
    Inventors: James Barrow, Georgia McGaughey, Philippe Nantermet, Hemaka Rajapakse, Harold Selnick, Shaun Stauffer, Joseph Vacca, Shawn Stachel, Craig Coburn, Matthew Stanton
  • 2,3,4,6-Substituted Pyridyl Derivative Compounds Useful As Beta-Secretase Inhibitors For The Treatment Of Alzheimer's Disease
    Publication number: 20070293497
    Abstract: The present invention is directed to 2,3,4,6-substituted pyridyl derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
    Type: Application
    Filed: November 18, 2005
    Publication date: December 20, 2007
    Inventors: Philippe Nantermet, Hemaka Rajapakse, Harold Selnick, James Barrow, Shaun Stauffer, Joseph Vacca, Keith Moore, Shawn Stachel, Mattahew Stanton
  • 2-Aminothiazole Compounds Useful As Aspartyl Protease Inhibitors
    Publication number: 20070203147
    Abstract: The present invention is directed to 2-aminothiazole compounds which are aspartyl protease inhibitors, and are inhibitors of both the beta-secretase enzyme and HIV protease, and that are useful in the treatment of diseases in which the beta-secretase enzyme and HIV are involved, such as Alzheimer's disease, HIV Infection and AIDS. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme and HIV protease are involved.
    Type: Application
    Filed: March 25, 2005
    Publication date: August 30, 2007
    Inventors: Craig Coburn, Amy Espeseth, Shawn Stachel, David Olsen, Daria Hazuda, M. Holloway
  • Phenylamide and pyridylamide beta-secretase inhibitors for the treatment of alzheimer's disease
    Publication number: 20070142634
    Abstract: The present invention is directed to phenylamide and pyridylamide derivative compounds of which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
    Type: Application
    Filed: December 15, 2004
    Publication date: June 21, 2007
    Inventors: James Barrow, Craig Coburn, Philippe Nantermet, Harold Selnick, Shawn Stachel, Matthew Stanton, Shaun Stauffer, Linghang Zhuang, Jennifer Davis
  • Macrocyclic beta-secretase inhibitors for the treatment of alzheimer's disease
    Publication number: 20070037784
    Abstract: The present invention is directed to compounds of formula I which are inhibitors of the beta-secretase enzyme and that are useful in the treatment or prevention of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the beta-secretase enzyme is involved.
    Type: Application
    Filed: August 10, 2004
    Publication date: February 15, 2007
    Inventors: Craig Coburn, Shawn Stachel, Joseph Vacca
  • Spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease
    Publication number: 20070021454
    Abstract: The present invention is directed to spiropiperidine compounds of formula (I) and tautomers thereof, which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
    Type: Application
    Filed: July 14, 2006
    Publication date: January 25, 2007
    Inventors: Craig Coburn, Melissa Egbertson, Samuel Graham, Georgia McGaughey, Shaun Stauffer, Hemaka Rajapakse, Philippe Nantermet, Shawn Stachel, Wenjin Yang, Wanli Lu, Bruce Fahr
  • Phenylcarboxamide beta-secretase inhibitors for the treatment of Alzheimer's disease
    Publication number: 20060264416
    Abstract: Disclosed are compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment or prevention of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease and pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the beta-secretase enzyme is involved.
    Type: Application
    Filed: July 28, 2006
    Publication date: November 23, 2006
    Inventors: Craig Coburn, Shawn Stachel, Joseph Vacca
  • N-alkyl phenylcarboxamide beta-secretase inhibitors for the treatment of alzheimer's disease
    Publication number: 20060161020
    Abstract: The present invention is directed to compounds which are inhibitors of the beta-secretase enzyme and which are useful in the treatment or prevention of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
    Type: Application
    Filed: June 25, 2004
    Publication date: July 20, 2006
    Inventors: Craig Coburn, Shawn Stachel, Joseph Vacca
  • Macrocyclic beta-secretase inhibitors for the treatment of alzheimer's disease
    Publication number: 20060058278
    Abstract: The present invention is directed to compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment or prevention of diseases in which the beta-secretase enzyme in involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the beta-secretase enzyme is involved.
    Type: Application
    Filed: January 2, 2004
    Publication date: March 16, 2006
    Inventors: Craig Coburn, Shawn Stachel, Joseph Vacca
  • Phenylcarboxamide beta-secretase inhibitors for the treatment of alzheimer's disease
    Publication number: 20060052615
    Abstract: Disclosed are compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment or prevention of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease and pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the beta-secretase enzyme is involved.
    Type: Application
    Filed: November 6, 2003
    Publication date: March 9, 2006
    Inventors: Craig Coburn, Shawn Stachel, Joseph Vacca