Abstract: The invention relates to modulators of Embryonic Ectoderm Development (EED) and/or Polycomb Repressive Complex 2 (PRC2) useful in the treatment of disorders and diseases associated with EEC and PRC2, being macrocyclic azolopyridine derivatives and compositions thereof of Formula I: or a pharmaceutically acceptable salt, prodrug, solvate, hydrate, enantiomer, isomer, or tautomer thereof, wherein X1, X2, X3, A1, A2, Y, R1, R2, R3, and R4 are as described herein.

Abstract: The disclosure is a fly fishing training line wherein the training line is attached to a traditional fly fishing rod housing a fly fishing line. The training line is comprised of a heavier line material than the fly fishing line per meter and is end-weighted having two types, a first and second type of cord, wherein the second type is heavier than the first type and a short segment of the second type is fitted between two segments of the first type of cord nearer the fly end of the line.

Abstract: An emergency communication system that is capable of broadcasting a live message to a specific zone of a protected structure, recording the live transmission, and repeating the recorded message to the same protected zone. In certain embodiments configured to protect multiple zones, the system further permits broadcast of a second live message to another zone of the structure, recording the second live broadcast, and repeating the second recorded message in the same zone to which the message was broadcast live. The system includes hardware such as a processing element and speaker assemblies and a computer program for instructing the processing element to carry out the transmission, recording, and re-broadcasting of messages through the speaker assemblies.

Abstract: An emergency communication system that is capable of broadcasting a live message to a specific zone of a protected structure, recording the live transmission, and repeating the recorded message to the same protected zone. In certain embodiments configured to protect multiple zones, the system further permits broadcast of a second live message to another zone of the structure, recording the second live broadcast, and repeating the second recorded message in the same zone to which the message was broadcast live. The system includes hardware such as a processing element and speaker assemblies and a computer program for instructing the processing element to carry out the transmission, recording, and re-broadcasting of messages through the speaker assemblies.

Abstract: An emergency communication system that is capable of broadcasting a live message to a specific zone of a protected structure, recording the live transmission, and repeating the recorded message to the same protected zone. In certain embodiments configured to protect multiple zones, the system further permits broadcast of a second live message to another zone of the structure, recording the second live broadcast, and repeating the second recorded message in the same zone to which the message was broadcast live. The system includes hardware such as a processing element and speaker assemblies and a computer program for instructing the processing element to carry out the transmission, recording, and re-broadcasting of messages through the speaker assemblies.

Abstract: An emergency communication system that is capable of broadcasting a live message to a specific zone of a protected structure, recording the live transmission, and repeating the recorded message to the same protected zone. In certain embodiments configured to protect multiple zones, the system further permits broadcast of a second live message to another zone of the structure, recording the second live broadcast, and repeating the second recorded message in the same zone to which the message was broadcast live. The system includes hardware such as a processing element and speaker assemblies and a computer program for instructing the processing element to carry out the transmission, recording, and re-broadcasting of messages through the speaker assemblies.

Abstract: This invention consists of a wind instrument mouthpiece primarily intended for trumpet or cornet, although it could be utilized for other wind instruments as well without departing from the concept of the invention. It features an angled shank as the preferred embodiment of the invention. The mouthpiece could also be constructed with a curved shank or with an angle at the juncture of the shank and the cup of the mouthpiece as alternative embodiments. The upswept angle of the mouthpiece allows the player to maintain a horizontal bell position while tilting their head downward. This mouthpiece configuration elevates the bell of the horn while in use which benefits the student musician both acoustically and aesthetically. The professional musician would benefit from using this mouthpiece during high register play during which time the demand on the players embouchure is shifted more to the upper lip resulting in a descending bell playing position.

Abstract: Disclosed is a mute that attaches over the bell of a wind instrument which can be used for practice or performance. The shell of this mute consists of a symmetrically shaped cylindrical plastic jar. Attached to the exterior of the mute shell is an illuminated ON-OFF switch that is connected to a 12 VDC blower fan motor and a 12 V AC adapter. The 12 VDC blower motor inlet is attached to a plastic inlet duct contained in the mute shell. The blower motor vent is attached to a plastic egress duct which exits the mute shell. The ventilation system is encompassed by acoustical foam. This mute muffles the sound of a wind instrument without altering its pitch or timbre, and without creating any additional pressure at the players lips.